| month | day | visitor | score | home | score |
|---|
| November | 5, 2010 | Clippers | 74 | Lakers | 76 |
| November | 7, 2010 | Wolves | 90 | Lakers | 116 |
| November | 8, 2010 | Lakers | 68 | Bucks | 98 |
| November | 10, 2010 | Lakers | 79 | Celtics | 101 |
| November | 16, 2010 | Kings | 76 | Lakers | 84 |
| November | 23, 2010 | Lakers | 108 | Grizzlies | 111 |
| November | 25, 2010 | Nuggets | 80 | Lakers | 94 |
| November | 27, 2010 | Warriors | 97 | Lakers | 100 |
| November | 29, 2010 | Lakers | 77 | Wolves | 117 |
| November | 30, 2010 | Lakers | 66 | Bobcats | 93 |
| December | 1, 2010 | Lakers | 84 | Hawks | 89 |
| December | 2, 2010 | Blazers | 85 | Lakers | 79 |
| December | 3, 2010 | Lakers | 89 | Wizards | 112 |
| December | 7, 2010 | Lakers | 87 | Pacers | 102 |
| December | 10, 2010 | Celtics | 74 | Lakers | 70 |
| December | 13, 2010 | Hornets | 97 | Lakers | 87 |
| December | 16, 2010 | Bucks | 98 | Lakers | 96 |
| December | 20, 2010 | Lakers | 72 | Jazz | 111 |
| December | 21, 2010 | Lakers | 106 | Warriors | 113 |
| December | 22, 2010 | Lakers | 79 | Suns | 74 |
| December | 25, 2010 | Spurs | 82 | Lakers | 101 |
| December | 27, 2010 | Rockets | 84 | Lakers | 100 |
| December | 28, 2010 | Lakers | 82 | Pistons | 93 |
| December | 29, 2010 | Warriors | 94 | Lakers | 93 |
| December | 30, 2010 | Lakers | 84 | Jazz | 100 |
| January | 2, 2011 | Lakers | 86 | Sonics | 97 |
| January | 3, 2011 | Bobcats | 104 | Lakers | 98 |
| January | 6, 2011 | Heat | 91 | Lakers | 87 |
| January | 10, 2011 | Lakers | 88 | Knicks | 92 |
| January | 14, 2011 | Clippers | 95 | Lakers | 77 |
| January | 16, 2011 | Rockets | 94 | Lakers | 78 |
| January | 17, 2011 | Lakers | 87 | Nuggets | 108 |
| January | 18, 2011 | Lakers | 73 | Mavericks | 85 |
| January | 19, 2011 | Grizzlies | 100 | Lakers | 103 |
| January | 20, 2011 | Knicks | 83 | Lakers | 80 |
| January | 21, 2011 | Kings | 66 | Lakers | 77 |
| January | 22, 2011 | Wolves | 84 | Lakers | 100 |
| January | 24, 2011 | Cavaliers | 92 | Lakers | 87 |
| January | 26, 2011 | Lakers | 82 | Wolves | 113 |
| January | 28, 2011 | Bulls | 79 | Lakers | 91 |
| January | 31, 2011 | Lakers | 80 | Heat | 101 |
| February | 1, 2011 | Lakers | 85 | Nuggets | 92 |
| February | 2, 2011 | Lakers | 66 | Magic | 84 |
| February | 6, 2011 | Lakers | 80 | Hornets | 96 |
| February | 7, 2011 | Blazers | 89 | Lakers | 75 |
| February | 15, 2011 | Sonics | 107 | Lakers | 86 |
| February | 17, 2011 | Jazz | 93 | Lakers | 98 |
| February | 18, 2011 | Lakers | 66 | Rockets | 102 |
| February | 27, 2011 | Lakers | 73 | Blazers | 82 |
| February | 28, 2011 | Lakers | 78 | Blazers | 93 |
| March | 2, 2011 | Grizzlies | 97 | Lakers | 111 |
| March | 3, 2011 | Lakers | 78 | Spurs | 83 |
| March | 4, 2011 | Magic | 75 | Lakers | 89 |
| March | 5, 2011 | 76ers | 72 | Lakers | 88 |
| March | 7, 2011 | Mavericks | 93 | Lakers | 77 |
| March | 8, 2011 | Nuggets | 90 | Lakers | 101 |
| March | 10, 2011 | Lakers | 87 | Kings | 97 |
| March | 14, 2011 | Lakers | 93 | Clippers | 72 |
| March | 16, 2011 | Lakers | 76 | Cavaliers | 86 |
| March | 17, 2011 | Spurs | 97 | Lakers | 80 |
| March | 18, 2011 | Lakers | 78 | Rockets | 98 |
| March | 19, 2011 | Lakers | 76 | Spurs | 79 |
| March | 20, 2011 | Lakers | 92 | Hornets | 102 |
| March | 21, 2011 | Lakers | 100 | Suns | 99 |
| March | 22, 2011 | Lakers | 60 | Grizzlies | 111 |
| March | 24, 2011 | Mavericks | 84 | Lakers | 71 |
| March | 25, 2011 | Hornets | 82 | Lakers | 100 |
| March | 28, 2011 | Hawks | 113 | Lakers | 93 |
| March | 30, 2011 | Lakers | 71 | Sonics | 110 |
| April | 5, 2011 | Jazz | 90 | Lakers | 93 |
| April | 9, 2011 | Lakers | 62 | Raptors | 98 |
| April | 10, 2011 | Lakers | 67 | Mavericks | 79 |
| April | 11, 2011 | Nets | 79 | Lakers | 83 |
| April | 12, 2011 | Lakers | 59 | Bulls | 75 |
| April | 14, 2011 | Pistons | 84 | Lakers | 86 |
| April | 16, 2011 | Pacers | 86 | Lakers | 78 |
| April | 17, 2011 | Lakers | 113 | Warriors | 105 |
| April | 21, 2011 | Lakers | 90 | Nets | 86 |
| April | 22, 2011 | Lakers | 82 | 76ers | 73 |
| April | 23, 2011 | Suns | 90 | Lakers | 75 |
| April | 29, 2011 | Wizards | 83 | Lakers | 93 |
| May | 1, 2011 | Raptors | 77 | Lakers | 80 |