| month | day | visitor | score | home | score |
|---|
| November | 3, 2022 | Spurs | 90 | Rockets | 99 |
| November | 6, 2022 | Spurs | 108 | Grizzlies | 103 |
| November | 7, 2022 | Spurs | 88 | Kings | 106 |
| November | 10, 2022 | Spurs | 104 | Clippers | 114 |
| November | 12, 2022 | Spurs | 95 | Sonics | 112 |
| November | 13, 2022 | Sonics | 98 | Spurs | 104 |
| November | 15, 2022 | Spurs | 81 | Wolves | 101 |
| November | 16, 2022 | Spurs | 97 | Suns | 107 |
| November | 18, 2022 | Spurs | 77 | Mavericks | 88 |
| November | 19, 2022 | Mavericks | 116 | Spurs | 86 |
| November | 20, 2022 | Rockets | 101 | Spurs | 83 |
| November | 21, 2022 | Suns | 89 | Spurs | 106 |
| November | 24, 2022 | Grizzlies | 101 | Spurs | 99 |
| November | 25, 2022 | Lakers | 118 | Spurs | 94 |
| November | 26, 2022 | Wolves | 104 | Spurs | 71 |
| November | 28, 2022 | Spurs | 113 | Nuggets | 110 |
| December | 3, 2022 | Spurs | 104 | Lakers | 130 |
| December | 9, 2022 | Blazers | 113 | Spurs | 82 |
| December | 13, 2022 | Spurs | 86 | Blazers | 120 |
| December | 16, 2022 | Nuggets | 128 | Spurs | 106 |
| December | 18, 2022 | Spurs | 118 | Jazz | 108 |
| December | 19, 2022 | Spurs | 107 | Pelicans | 76 |
| December | 20, 2022 | Kings | 103 | Spurs | 99 |
| December | 22, 2022 | Clippers | 100 | Spurs | 129 |
| December | 24, 2022 | Jazz | 91 | Spurs | 95 |
| December | 28, 2022 | Warriors | 99 | Spurs | 95 |
| January | 1, 2023 | Pelicans | 95 | Spurs | 85 |
| January | 4, 2023 | Spurs | 109 | Warriors | 118 |