| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Pistons | 78 | Magic | 92 |
| November | 5, 2022 | Magic | 73 | Pistons | 82 |
| November | 11, 2022 | Pistons | 54 | Nets | 89 |
| November | 18, 2022 | Knicks | 83 | Pistons | 85 |
| November | 19, 2022 | Cavaliers | 64 | Pistons | 73 |
| November | 20, 2022 | Pistons | 88 | Raptors | 129 |
| November | 22, 2022 | 76ers | 88 | Pistons | 71 |
| November | 25, 2022 | Pistons | 65 | Pacers | 80 |
| November | 26, 2022 | Pistons | 89 | Cavaliers | 95 |
| November | 27, 2022 | Pistons | 95 | Bucks | 87 |
| November | 28, 2022 | Wizards | 105 | Pistons | 84 |
| November | 29, 2022 | Heat | 101 | Pistons | 76 |
| November | 30, 2022 | Pistons | 70 | 76ers | 67 |
| December | 3, 2022 | Pistons | 88 | Knicks | 77 |
| December | 9, 2022 | Nets | 81 | Pistons | 91 |
| December | 11, 2022 | Celtics | 74 | Pistons | 81 |
| December | 13, 2022 | Pistons | 74 | Heat | 84 |
| December | 16, 2022 | Bulls | 76 | Pistons | 84 |
| December | 21, 2022 | Pistons | 62 | Celtics | 87 |
| December | 22, 2022 | Pistons | 84 | Bulls | 80 |
| December | 23, 2022 | Hornets | 91 | Pistons | 86 |
| December | 24, 2022 | Pistons | 71 | Hornets | 90 |
| December | 25, 2022 | Pacers | 93 | Pistons | 81 |
| December | 28, 2022 | Hawks | 84 | Pistons | 81 |
| December | 29, 2022 | Bucks | 72 | Pistons | 75 |
| January | 3, 2023 | Pistons | 74 | Hawks | 67 |
| January | 4, 2023 | Raptors | 104 | Pistons | 82 |
| January | 5, 2023 | Pistons | 68 | Wizards | 101 |