| month | day | visitor | score | home | score |
|---|
| November | 3, 2022 | Suns | 102 | Lakers | 116 |
| November | 4, 2022 | Lakers | 102 | Kings | 106 |
| November | 5, 2022 | Jazz | 71 | Lakers | 104 |
| November | 11, 2022 | Lakers | 111 | Rockets | 79 |
| November | 12, 2022 | Mavericks | 87 | Lakers | 122 |
| November | 15, 2022 | Kings | 96 | Lakers | 108 |
| November | 16, 2022 | Sonics | 115 | Lakers | 122 |
| November | 19, 2022 | Clippers | 119 | Lakers | 104 |
| November | 20, 2022 | Blazers | 85 | Lakers | 108 |
| November | 21, 2022 | Lakers | 103 | Blazers | 105 |
| November | 23, 2022 | Lakers | 98 | Jazz | 96 |
| November | 24, 2022 | Lakers | 92 | Wolves | 80 |
| November | 25, 2022 | Lakers | 118 | Spurs | 94 |
| November | 29, 2022 | Warriors | 78 | Lakers | 105 |
| November | 30, 2022 | Grizzlies | 104 | Lakers | 130 |
| December | 3, 2022 | Spurs | 104 | Lakers | 130 |
| December | 10, 2022 | Wolves | 59 | Lakers | 99 |
| December | 11, 2022 | Lakers | 88 | Mavericks | 74 |
| December | 15, 2022 | Lakers | 116 | Warriors | 93 |
| December | 16, 2022 | Lakers | 103 | Suns | 100 |
| December | 21, 2022 | Lakers | 98 | Pelicans | 81 |
| December | 22, 2022 | Lakers | 102 | Grizzlies | 119 |
| December | 23, 2022 | Rockets | 78 | Lakers | 103 |
| December | 24, 2022 | Lakers | 108 | Sonics | 105 |
| December | 30, 2022 | Nuggets | 97 | Lakers | 119 |
| January | 3, 2023 | Lakers | 107 | Clippers | 109 |
| January | 4, 2023 | Lakers | 118 | Nuggets | 97 |
| January | 5, 2023 | Pelicans | 78 | Lakers | 83 |