| month | day | visitor | score | home | score |
|---|
| November | 7, 2024 | Nuggets | 80 | Pistons | 84 |
| November | 8, 2024 | Pistons | 83 | Sonics | 112 |
| November | 10, 2024 | Clippers | 78 | Pistons | 71 |
| November | 11, 2024 | Jazz | 82 | Pistons | 85 |
| November | 17, 2024 | Pistons | 80 | Warriors | 97 |
| November | 18, 2024 | Pistons | 56 | 76ers | 80 |
| November | 20, 2024 | Pistons | 68 | Pelicans | 77 |
| November | 21, 2024 | Bulls | 118 | Pistons | 84 |
| November | 22, 2024 | Bucks | 91 | Pistons | 87 |
| November | 23, 2024 | Pistons | 54 | Heat | 84 |
| November | 24, 2024 | Pistons | 82 | Celtics | 101 |
| November | 25, 2024 | Pistons | 80 | Suns | 79 |
| November | 26, 2024 | Pistons | 73 | Nets | 103 |
| November | 27, 2024 | Cavaliers | 87 | Pistons | 76 |
| December | 8, 2024 | Pistons | 89 | Pacers | 98 |
| December | 12, 2024 | Pistons | 70 | Raptors | 108 |
| December | 15, 2024 | Knicks | 97 | Pistons | 81 |
| December | 17, 2024 | Pistons | 70 | Cavaliers | 84 |
| December | 21, 2024 | Pistons | 88 | Bulls | 96 |
| December | 22, 2024 | Pistons | 75 | Nets | 99 |
| December | 23, 2024 | Pistons | 75 | Raptors | 104 |
| December | 25, 2024 | Pistons | 70 | Hornets | 104 |
| December | 28, 2024 | Pistons | 74 | Rockets | 83 |
| December | 29, 2024 | Hawks | 86 | Pistons | 89 |
| December | 31, 2024 | Knicks | 101 | Pistons | 61 |
| January | 1, 2025 | Pistons | 102 | Hawks | 115 |
| January | 4, 2025 | Pistons | 68 | Bucks | 84 |
| January | 5, 2025 | Pistons | 75 | Celtics | 116 |
| January | 9, 2025 | Pelicans | 87 | Pistons | 72 |
| January | 11, 2025 | Warriors | 93 | Pistons | 77 |
| January | 13, 2025 | 76ers | 110 | Pistons | 88 |
| January | 14, 2025 | Rockets | 74 | Pistons | 71 |
| January | 16, 2025 | Wolves | 84 | Pistons | 76 |
| January | 17, 2025 | Wizards | 91 | Pistons | 65 |
| January | 21, 2025 | Grizzlies | 87 | Pistons | 61 |
| January | 23, 2025 | Pistons | 53 | Clippers | 107 |
| January | 26, 2025 | Pistons | 64 | Knicks | 100 |
| January | 29, 2025 | Pistons | 53 | Wizards | 97 |
| January | 30, 2025 | Pistons | 57 | Wizards | 105 |
| February | 1, 2025 | Suns | 103 | Pistons | 97 |
| February | 2, 2025 | Pacers | 89 | Pistons | 96 |
| February | 5, 2025 | Pistons | 81 | Bulls | 130 |
| February | 6, 2025 | Hornets | 80 | Pistons | 79 |
| February | 11, 2025 | Magic | 77 | Pistons | 96 |
| February | 12, 2025 | Pacers | 91 | Pistons | 96 |
| February | 15, 2025 | Pistons | 100 | Wolves | 114 |
| February | 17, 2025 | Pistons | 74 | 76ers | 98 |
| February | 18, 2025 | Heat | 72 | Pistons | 70 |
| February | 19, 2025 | Pistons | 60 | Bucks | 91 |
| February | 20, 2025 | Pistons | 58 | Lakers | 102 |
| February | 21, 2025 | Raptors | 111 | Pistons | 86 |
| February | 22, 2025 | Celtics | 81 | Pistons | 85 |
| February | 23, 2025 | Blazers | 85 | Pistons | 76 |
| February | 24, 2025 | Lakers | 116 | Pistons | 75 |
| February | 26, 2025 | Magic | 79 | Pistons | 84 |
| February | 27, 2025 | Pistons | 55 | Grizzlies | 65 |
| February | 28, 2025 | Pistons | 89 | Mavericks | 107 |
| March | 5, 2025 | Heat | 62 | Pistons | 73 |
| March | 6, 2025 | Mavericks | 110 | Pistons | 99 |
| March | 7, 2025 | Bulls | 97 | Pistons | 79 |
| March | 8, 2025 | Pistons | 69 | Kings | 95 |
| March | 11, 2025 | Nets | 99 | Pistons | 78 |
| March | 15, 2025 | Sonics | 117 | Pistons | 92 |
| March | 16, 2025 | Nets | 89 | Pistons | 63 |
| March | 19, 2025 | Pistons | 64 | Hornets | 95 |
| March | 23, 2025 | Pistons | 75 | Spurs | 84 |
| March | 28, 2025 | Hawks | 94 | Pistons | 99 |
| April | 1, 2025 | Cavaliers | 71 | Pistons | 80 |
| April | 2, 2025 | Kings | 99 | Pistons | 64 |
| April | 4, 2025 | Pistons | 94 | Blazers | 111 |
| April | 5, 2025 | Celtics | 93 | Pistons | 84 |
| April | 6, 2025 | Pistons | 81 | Magic | 95 |
| April | 10, 2025 | Pistons | 101 | Nuggets | 87 |
| April | 14, 2025 | 76ers | 96 | Pistons | 72 |
| April | 16, 2025 | Bucks | 115 | Pistons | 92 |
| April | 19, 2025 | Pistons | 64 | Heat | 91 |
| April | 20, 2025 | Pistons | 78 | Knicks | 99 |
| April | 22, 2025 | Spurs | 102 | Pistons | 72 |
| April | 28, 2025 | Pistons | 69 | Cavaliers | 72 |
| April | 29, 2025 | Pistons | 80 | Jazz | 112 |
| May | 1, 2025 | Wizards | 92 | Pistons | 72 |
| May | 2, 2025 | Pistons | 80 | Magic | 78 |