| month | day | visitor | score | home | score |
|---|
| November | 6, 2005 | Jazz | 91 | Spurs | 80 |
| November | 11, 2005 | Pacers | 88 | Spurs | 83 |
| November | 14, 2005 | Bucks | 71 | Spurs | 91 |
| November | 16, 2005 | Celtics | 64 | Spurs | 93 |
| November | 17, 2005 | Spurs | 79 | Blazers | 83 |
| November | 18, 2005 | Spurs | 87 | Nuggets | 99 |
| November | 19, 2005 | Spurs | 70 | Wolves | 68 |
| November | 20, 2005 | Knicks | 90 | Spurs | 114 |
| November | 25, 2005 | Spurs | 83 | Hornets | 98 |
| November | 26, 2005 | Grizzlies | 74 | Spurs | 63 |
| November | 27, 2005 | Mavericks | 91 | Spurs | 86 |
| November | 28, 2005 | Mavericks | 76 | Spurs | 78 |
| November | 30, 2005 | Spurs | 113 | Knicks | 121 |
| December | 1, 2005 | Wolves | 91 | Spurs | 80 |
| December | 3, 2005 | Spurs | 77 | Heat | 84 |
| December | 6, 2005 | Spurs | 82 | Mavericks | 85 |
| December | 8, 2005 | Spurs | 82 | Pacers | 95 |
| December | 9, 2005 | Spurs | 76 | Warriors | 104 |
| December | 12, 2005 | Wolves | 85 | Spurs | 95 |
| December | 13, 2005 | Hornets | 82 | Spurs | 95 |
| December | 16, 2005 | Spurs | 84 | Kings | 116 |
| December | 18, 2005 | Spurs | 104 | Grizzlies | 113 |
| December | 19, 2005 | Sonics | 61 | Spurs | 81 |
| December | 23, 2005 | Rockets | 76 | Spurs | 86 |
| December | 24, 2005 | Spurs | 80 | Magic | 98 |
| December | 26, 2005 | Spurs | 78 | Mavericks | 72 |
| December | 27, 2005 | Spurs | 64 | Blazers | 84 |
| December | 28, 2005 | Pistons | 115 | Spurs | 113 |
| December | 29, 2005 | Blazers | 81 | Spurs | 84 |
| December | 30, 2005 | Nuggets | 95 | Spurs | 108 |
| January | 2, 2006 | Spurs | 90 | Bulls | 91 |
| January | 3, 2006 | Spurs | 84 | Hawks | 90 |
| January | 8, 2006 | Warriors | 81 | Spurs | 92 |
| January | 10, 2006 | Spurs | 85 | Kings | 111 |
| January | 18, 2006 | Bulls | 90 | Spurs | 85 |
| January | 19, 2006 | Spurs | 86 | Wolves | 78 |
| January | 27, 2006 | Clippers | 84 | Spurs | 97 |
| January | 28, 2006 | Spurs | 82 | Lakers | 78 |
| January | 30, 2006 | Hawks | 92 | Spurs | 95 |
| January | 31, 2006 | Cavaliers | 78 | Spurs | 90 |
| February | 2, 2006 | Spurs | 94 | Clippers | 93 |
| February | 9, 2006 | Spurs | 72 | Nets | 84 |
| February | 10, 2006 | Suns | 95 | Spurs | 66 |
| February | 12, 2006 | Rockets | 80 | Spurs | 78 |
| February | 14, 2006 | Spurs | 97 | Sonics | 74 |
| February | 15, 2006 | Bullets | 68 | Spurs | 84 |
| February | 18, 2006 | Spurs | 73 | Celtics | 90 |
| February | 19, 2006 | Spurs | 102 | Clippers | 86 |
| February | 20, 2006 | Spurs | 87 | Wolves | 96 |
| February | 21, 2006 | Lakers | 80 | Spurs | 88 |
| February | 23, 2006 | Spurs | 67 | Raptors | 83 |
| February | 25, 2006 | Spurs | 75 | Sonics | 89 |
| February | 26, 2006 | Spurs | 74 | Jazz | 99 |
| March | 1, 2006 | Spurs | 79 | Rockets | 83 |
| March | 2, 2006 | Warriors | 95 | Spurs | 94 |
| March | 4, 2006 | Spurs | 90 | Grizzlies | 85 |
| March | 9, 2006 | Spurs | 62 | Jazz | 79 |
| March | 11, 2006 | Suns | 76 | Spurs | 94 |
| March | 12, 2006 | Spurs | 66 | Pistons | 90 |
| March | 14, 2006 | Magic | 103 | Spurs | 91 |
| March | 15, 2006 | Spurs | 86 | 76ers | 93 |
| March | 16, 2006 | Spurs | 60 | Bullets | 81 |
| March | 21, 2006 | Spurs | 80 | Cavaliers | 72 |
| March | 24, 2006 | Spurs | 71 | Rockets | 84 |
| March | 25, 2006 | Grizzlies | 94 | Spurs | 98 |
| March | 26, 2006 | Jazz | 88 | Spurs | 89 |
| March | 27, 2006 | Mavericks | 91 | Spurs | 99 |
| March | 28, 2006 | Heat | 98 | Spurs | 87 |
| March | 29, 2006 | Spurs | 66 | Grizzlies | 108 |
| April | 1, 2006 | 76ers | 93 | Spurs | 95 |
| April | 2, 2006 | Spurs | 81 | Bucks | 75 |
| April | 3, 2006 | Nuggets | 98 | Spurs | 103 |
| April | 7, 2006 | Spurs | 86 | Lakers | 93 |
| April | 8, 2006 | Nuggets | 96 | Spurs | 103 |
| April | 9, 2006 | Spurs | 80 | Nuggets | 96 |
| April | 12, 2006 | Jazz | 104 | Spurs | 92 |
| April | 16, 2006 | Nets | 85 | Spurs | 95 |
| April | 19, 2006 | Raptors | 90 | Spurs | 105 |
| April | 20, 2006 | Spurs | 71 | Suns | 84 |
| April | 22, 2006 | Kings | 81 | Spurs | 73 |
| April | 23, 2006 | Rockets | 77 | Spurs | 81 |
| April | 25, 2006 | Sonics | 75 | Spurs | 99 |