| month | day | visitor | score | home | score |
|---|
| November | 2, 2005 | Bucks | 81 | Spurs | 88 |
| November | 3, 2005 | Bullets | 86 | Spurs | 88 |
| November | 4, 2005 | 76ers | 89 | Spurs | 83 |
| November | 5, 2005 | Spurs | 79 | Rockets | 91 |
| November | 6, 2005 | Jazz | 77 | Spurs | 75 |
| November | 10, 2005 | Spurs | 78 | Bucks | 101 |
| November | 11, 2005 | Spurs | 84 | Bullets | 98 |
| November | 12, 2005 | Spurs | 81 | 76ers | 89 |
| November | 13, 2005 | Spurs | 62 | Rockets | 85 |
| November | 14, 2005 | Spurs | 79 | Jazz | 99 |
| November | 20, 2005 | Bucks | 89 | Spurs | 90 |
| November | 21, 2005 | Spurs | 79 | Bullets | 89 |
| November | 22, 2005 | Spurs | 70 | 76ers | 99 |
| November | 23, 2005 | Spurs | 68 | Rockets | 92 |
| November | 24, 2005 | Spurs | 90 | Jazz | 81 |
| December | 1, 2005 | Rockets | 96 | Spurs | 82 |
| December | 2, 2005 | Spurs | 71 | Jazz | 69 |
| December | 3, 2005 | Bullets | 79 | Spurs | 96 |
| December | 4, 2005 | 76ers | 89 | Spurs | 82 |
| December | 7, 2005 | Bucks | 97 | Spurs | 92 |
| December | 8, 2005 | 76ers | 68 | Spurs | 73 |
| December | 9, 2005 | Spurs | 76 | Rockets | 85 |
| December | 10, 2005 | Spurs | 76 | Bucks | 90 |
| December | 12, 2005 | Wolves | | Spurs | |
| December | 13, 2005 | Hornets | | Spurs | |
| December | 16, 2005 | Spurs | | Kings | |
| December | 18, 2005 | Spurs | | Grizzlies | |
| December | 19, 2005 | Sonics | | Spurs | |
| December | 23, 2005 | Rockets | | Spurs | |
| December | 24, 2005 | Spurs | | Magic | |
| December | 26, 2005 | Spurs | | Mavericks | |
| December | 27, 2005 | Spurs | | Blazers | |
| December | 28, 2005 | Pistons | | Spurs | |
| December | 29, 2005 | Blazers | | Spurs | |
| December | 30, 2005 | Nuggets | | Spurs | |
| January | 2, 2006 | Spurs | | Bulls | |
| January | 3, 2006 | Spurs | | Hawks | |
| January | 8, 2006 | Warriors | | Spurs | |
| January | 10, 2006 | Spurs | | Kings | |
| January | 18, 2006 | Bulls | | Spurs | |
| January | 19, 2006 | Spurs | | Wolves | |
| January | 27, 2006 | Clippers | | Spurs | |
| January | 28, 2006 | Spurs | | Lakers | |
| January | 30, 2006 | Hawks | | Spurs | |
| January | 31, 2006 | Cavaliers | | Spurs | |
| February | 2, 2006 | Spurs | | Clippers | |
| February | 9, 2006 | Spurs | | Nets | |
| February | 10, 2006 | Suns | | Spurs | |
| February | 12, 2006 | Rockets | | Spurs | |
| February | 14, 2006 | Spurs | | Sonics | |
| February | 15, 2006 | Bullets | | Spurs | |
| February | 18, 2006 | Spurs | | Celtics | |
| February | 19, 2006 | Spurs | | Clippers | |
| February | 20, 2006 | Spurs | | Wolves | |
| February | 21, 2006 | Lakers | | Spurs | |
| February | 23, 2006 | Spurs | | Raptors | |
| February | 25, 2006 | Spurs | | Sonics | |
| February | 26, 2006 | Spurs | | Jazz | |
| March | 1, 2006 | Spurs | | Rockets | |
| March | 2, 2006 | Warriors | | Spurs | |
| March | 4, 2006 | Spurs | | Grizzlies | |
| March | 9, 2006 | Spurs | | Jazz | |
| March | 11, 2006 | Suns | | Spurs | |
| March | 12, 2006 | Spurs | | Pistons | |
| March | 14, 2006 | Magic | | Spurs | |
| March | 15, 2006 | Spurs | | 76ers | |
| March | 16, 2006 | Spurs | | Bullets | |
| March | 21, 2006 | Spurs | | Cavaliers | |
| March | 24, 2006 | Spurs | | Rockets | |
| March | 25, 2006 | Grizzlies | | Spurs | |
| March | 26, 2006 | Jazz | | Spurs | |
| March | 27, 2006 | Mavericks | | Spurs | |
| March | 28, 2006 | Heat | | Spurs | |
| March | 29, 2006 | Spurs | | Grizzlies | |
| April | 1, 2006 | 76ers | | Spurs | |
| April | 2, 2006 | Spurs | | Bucks | |
| April | 3, 2006 | Nuggets | | Spurs | |
| April | 7, 2006 | Spurs | | Lakers | |
| April | 8, 2006 | Nuggets | | Spurs | |
| April | 9, 2006 | Spurs | | Nuggets | |
| April | 12, 2006 | Jazz | | Spurs | |
| April | 16, 2006 | Nets | | Spurs | |
| April | 19, 2006 | Raptors | | Spurs | |
| April | 20, 2006 | Spurs | | Suns | |
| April | 22, 2006 | Kings | | Spurs | |
| April | 23, 2006 | Rockets | | Spurs | |
| April | 25, 2006 | Sonics | | Spurs | |