| month | day | visitor | score | home | score |
|---|
| November | 2, 2000 | Bucks | 82 | Cavaliers | 75 |
| November | 4, 2000 | Cavaliers | 103 | Mavericks | 96 |
| November | 5, 2000 | Nuggets | 65 | Cavaliers | 77 |
| November | 9, 2000 | Bulls | 79 | Cavaliers | 82 |
| November | 10, 2000 | Cavaliers | 75 | Nuggets | 74 |
| November | 14, 2000 | Cavaliers | 84 | Bucks | 61 |
| November | 16, 2000 | Cavaliers | 74 | Bulls | 84 |
| November | 20, 2000 | Bucks | 68 | Cavaliers | 85 |
| November | 25, 2000 | Mavericks | 95 | Cavaliers | 91 |
| November | 28, 2000 | Cavaliers | 74 | Bulls | 83 |
| December | 2, 2000 | Cavaliers | 85 | Bucks | 89 |
| December | 4, 2000 | Bulls | 88 | Cavaliers | 99 |
| December | 5, 2000 | Cavaliers | 89 | Bucks | 102 |
| December | 9, 2000 | Cavaliers | 47 | Bucks | 84 |
| December | 11, 2000 | Jazz | 85 | Cavaliers | 92 |
| December | 12, 2000 | Bucks | 81 | Cavaliers | 93 |
| December | 16, 2000 | Cavaliers | 70 | Bulls | 86 |
| December | 17, 2000 | Cavaliers | 68 | Bucks | 78 |
| December | 27, 2000 | Bucks | 64 | Cavaliers | 67 |
| December | 28, 2000 | Cavaliers | 88 | Jazz | 83 |
| December | 29, 2000 | Bulls | 68 | Cavaliers | 98 |
| January | 2, 2001 | Bulls | 59 | Cavaliers | 80 |
| January | 6, 2001 | Cavaliers | 81 | Bucks | 71 |
| January | 7, 2001 | Cavaliers | 84 | Bulls | 69 |
| January | 14, 2001 | Bulls | 72 | Cavaliers | 73 |
| January | 16, 2001 | Cavaliers | 72 | Bulls | 68 |
| January | 18, 2001 | Bulls | 82 | Cavaliers | 92 |
| January | 24, 2001 | Bucks | 87 | Cavaliers | 92 |