| month | day | visitor | score | home | score |
|---|
| November | 3, 2005 | Rockets | 97 | Hornets | 100 |
| November | 7, 2005 | Rockets | 80 | Grizzlies | 89 |
| November | 8, 2005 | Knicks | 121 | Rockets | 112 |
| November | 9, 2005 | Nets | 69 | Rockets | 92 |
| November | 10, 2005 | Sonics | 88 | Rockets | 75 |
| November | 12, 2005 | Rockets | 78 | Grizzlies | 86 |
| November | 13, 2005 | Rockets | 95 | Kings | 115 |
| November | 16, 2005 | Rockets | 90 | Sonics | 92 |
| November | 19, 2005 | Suns | 84 | Rockets | 89 |
| November | 20, 2005 | Rockets | 90 | Grizzlies | 92 |
| November | 21, 2005 | Rockets | 75 | Celtics | 102 |
| November | 23, 2005 | Bullets | 99 | Rockets | 98 |
| November | 27, 2005 | Wolves | 91 | Rockets | 111 |
| November | 29, 2005 | Sonics | 61 | Rockets | 77 |
| November | 30, 2005 | Heat | 77 | Rockets | 91 |
| December | 1, 2005 | Rockets | 71 | Pistons | 100 |
| December | 3, 2005 | Rockets | 107 | Kings | 93 |
| December | 5, 2005 | Grizzlies | 88 | Rockets | 89 |
| December | 7, 2005 | Rockets | 82 | Wolves | 99 |
| December | 8, 2005 | Warriors | 84 | Rockets | 99 |
| December | 9, 2005 | Suns | 82 | Rockets | 71 |
| December | 11, 2005 | Rockets | 87 | Nets | 74 |
| December | 12, 2005 | Rockets | 98 | Raptors | 85 |
| December | 17, 2005 | Jazz | 102 | Rockets | 82 |
| December | 19, 2005 | Rockets | 88 | 76ers | 120 |
| December | 21, 2005 | Jazz | 97 | Rockets | 87 |
| December | 23, 2005 | Rockets | 75 | Spurs | 81 |
| December | 24, 2005 | Bulls | 84 | Rockets | 98 |
| December | 29, 2005 | Pacers | | Rockets | |
| December | 31, 2005 | Raptors | | Rockets | |
| January | 1, 2006 | Cavaliers | | Rockets | |
| January | 9, 2006 | Mavericks | | Rockets | |
| January | 11, 2006 | Rockets | | Hawks | |
| January | 15, 2006 | Grizzlies | | Rockets | |
| January | 16, 2006 | Jazz | | Rockets | |
| January | 18, 2006 | Hawks | | Rockets | |
| January | 24, 2006 | Rockets | | Mavericks | |
| January | 26, 2006 | Rockets | | Nuggets | |
| January | 27, 2006 | Blazers | | Rockets | |
| January | 28, 2006 | Rockets | | Bucks | |
| January | 29, 2006 | Pistons | | Rockets | |
| January | 30, 2006 | Rockets | | Blazers | |
| January | 31, 2006 | Hornets | | Rockets | |
| February | 4, 2006 | Rockets | | Cavaliers | |
| February | 10, 2006 | Rockets | | Heat | |
| February | 12, 2006 | Rockets | | Spurs | |
| February | 13, 2006 | Lakers | | Rockets | |
| February | 15, 2006 | Rockets | | Wolves | |
| February | 17, 2006 | Rockets | | Jazz | |
| February | 21, 2006 | Rockets | | Blazers | |
| February | 22, 2006 | Rockets | | Knicks | |
| February | 23, 2006 | Rockets | | Suns | |
| March | 1, 2006 | Spurs | | Rockets | |
| March | 2, 2006 | Rockets | | Lakers | |
| March | 5, 2006 | Lakers | | Rockets | |
| March | 6, 2006 | Nuggets | | Rockets | |
| March | 7, 2006 | Kings | | Rockets | |
| March | 9, 2006 | Rockets | | Pacers | |
| March | 10, 2006 | Nuggets | | Rockets | |
| March | 13, 2006 | Magic | | Rockets | |
| March | 14, 2006 | Rockets | | Clippers | |
| March | 17, 2006 | Rockets | | Mavericks | |
| March | 18, 2006 | Nuggets | | Rockets | |
| March | 21, 2006 | Bucks | | Rockets | |
| March | 22, 2006 | Rockets | | Wolves | |
| March | 23, 2006 | Rockets | | Jazz | |
| March | 24, 2006 | Spurs | | Rockets | |
| March | 25, 2006 | Mavericks | | Rockets | |
| March | 29, 2006 | Celtics | | Rockets | |
| March | 31, 2006 | Rockets | | Magic | |
| April | 4, 2006 | 76ers | | Rockets | |
| April | 6, 2006 | Wolves | | Rockets | |
| April | 9, 2006 | Warriors | | Rockets | |
| April | 12, 2006 | Mavericks | | Rockets | |
| April | 14, 2006 | Rockets | | Nuggets | |
| April | 19, 2006 | Rockets | | Warriors | |
| April | 20, 2006 | Clippers | | Rockets | |
| April | 21, 2006 | Rockets | | Bullets | |
| April | 22, 2006 | Rockets | | Bulls | |
| April | 23, 2006 | Rockets | | Spurs | |
| April | 24, 2006 | Rockets | | Lakers | |
| April | 25, 2006 | Rockets | | Clippers | |