| month | day | visitor | score | home | score |
|---|
| November | 7, 2005 | Pistons | 87 | Magic | 102 |
| November | 8, 2005 | Pistons | 100 | Celtics | 103 |
| November | 9, 2005 | Hawks | 121 | Pistons | 132 |
| November | 10, 2005 | Cavaliers | 102 | Pistons | 116 |
| November | 11, 2005 | Pistons | 90 | Nets | 66 |
| November | 12, 2005 | Warriors | 75 | Pistons | 110 |
| November | 14, 2005 | Raptors | 85 | Pistons | 95 |
| November | 16, 2005 | Clippers | 92 | Pistons | 122 |
| November | 19, 2005 | Pistons | 100 | Cavaliers | 89 |
| November | 20, 2005 | Pistons | 88 | Celtics | 101 |
| November | 21, 2005 | Hornets | 89 | Pistons | 118 |
| November | 22, 2005 | Pistons | 100 | Bulls | 91 |
| November | 24, 2005 | Pistons | 129 | Kings | 92 |
| November | 25, 2005 | Lakers | 89 | Pistons | 120 |
| November | 28, 2005 | Pistons | 117 | Nuggets | 98 |
| November | 30, 2005 | Pistons | 102 | 76ers | 114 |
| December | 1, 2005 | Rockets | 71 | Pistons | 100 |
| December | 2, 2005 | Bulls | 82 | Pistons | 107 |
| December | 7, 2005 | Pistons | 103 | Raptors | 69 |
| December | 8, 2005 | Pistons | 101 | Clippers | 105 |
| December | 9, 2005 | Hawks | 116 | Pistons | 126 |
| December | 11, 2005 | Pistons | 105 | Bullets | 90 |
| December | 15, 2005 | Pistons | 83 | Hawks | 87 |
| December | 17, 2005 | Pistons | 91 | Grizzlies | 96 |
| December | 23, 2005 | Blazers | 83 | Pistons | 97 |
| December | 26, 2005 | Cavaliers | 84 | Pistons | 108 |
| December | 27, 2005 | Pistons | 103 | 76ers | 98 |
| December | 28, 2005 | Pistons | 78 | Spurs | 68 |
| December | 31, 2005 | Pistons | | Blazers | |
| January | 1, 2006 | Pistons | | Hornets | |
| January | 3, 2006 | Pistons | | Bucks | |
| January | 6, 2006 | Bucks | | Pistons | |
| January | 7, 2006 | Nuggets | | Pistons | |
| January | 9, 2006 | Pistons | | Knicks | |
| January | 10, 2006 | Pistons | | Nets | |
| January | 11, 2006 | Pistons | | Heat | |
| January | 12, 2006 | Pistons | | Knicks | |
| January | 13, 2006 | Pacers | | Pistons | |
| January | 16, 2006 | Pistons | | Cavaliers | |
| January | 18, 2006 | Pistons | | Heat | |
| January | 23, 2006 | Pistons | | Raptors | |
| January | 24, 2006 | Magic | | Pistons | |
| January | 26, 2006 | Wolves | | Pistons | |
| January | 29, 2006 | Pistons | | Rockets | |
| February | 1, 2006 | Raptors | | Pistons | |
| February | 8, 2006 | Kings | | Pistons | |
| February | 9, 2006 | Celtics | | Pistons | |
| February | 12, 2006 | Hornets | | Pistons | |
| February | 15, 2006 | Pistons | | Bucks | |
| February | 16, 2006 | Bucks | | Pistons | |
| February | 19, 2006 | Hawks | | Pistons | |
| February | 20, 2006 | Mavericks | | Pistons | |
| February | 21, 2006 | Pistons | | Suns | |
| February | 22, 2006 | Pistons | | Wolves | |
| February | 27, 2006 | Suns | | Pistons | |
| February | 28, 2006 | Pistons | | Bullets | |
| March | 1, 2006 | Sonics | | Pistons | |
| March | 3, 2006 | Bulls | | Pistons | |
| March | 6, 2006 | Bulls | | Pistons | |
| March | 8, 2006 | Pistons | | Bulls | |
| March | 12, 2006 | Spurs | | Pistons | |
| March | 16, 2006 | Magic | | Pistons | |
| March | 17, 2006 | Pistons | | Jazz | |
| March | 19, 2006 | Pistons | | Hornets | |
| March | 22, 2006 | Pistons | | Pacers | |
| March | 25, 2006 | Pistons | | Sonics | |
| March | 26, 2006 | Pistons | | Pacers | |
| March | 27, 2006 | Cavaliers | | Pistons | |
| March | 28, 2006 | Pistons | | Hawks | |
| March | 31, 2006 | Hornets | | Pistons | |
| April | 1, 2006 | Heat | | Pistons | |
| April | 2, 2006 | Pistons | | Mavericks | |
| April | 3, 2006 | 76ers | | Pistons | |
| April | 7, 2006 | Pacers | | Pistons | |
| April | 9, 2006 | Pistons | | Lakers | |
| April | 10, 2006 | Grizzlies | | Pistons | |
| April | 11, 2006 | Bullets | | Pistons | |
| April | 14, 2006 | Jazz | | Pistons | |
| April | 15, 2006 | Nets | | Pistons | |
| April | 17, 2006 | Pistons | | Warriors | |
| April | 20, 2006 | Knicks | | Pistons | |
| April | 24, 2006 | Bucks | | Pistons | |