| month | day | visitor | score | home | score |
|---|
| November | 6, 2005 | Bucks | 78 | Lakers | 81 |
| November | 7, 2005 | Lakers | 81 | Mavericks | 100 |
| November | 8, 2005 | Lakers | 94 | Pacers | 93 |
| November | 12, 2005 | Lakers | 98 | Nets | 67 |
| November | 13, 2005 | Lakers | 109 | Knicks | 113 |
| November | 17, 2005 | Lakers | 86 | Clippers | 105 |
| November | 23, 2005 | Lakers | 109 | Warriors | 97 |
| November | 25, 2005 | Lakers | 89 | Pistons | 120 |
| November | 26, 2005 | Nuggets | 94 | Lakers | 115 |
| November | 30, 2005 | Hawks | 103 | Lakers | 102 |
| December | 1, 2005 | Blazers | 102 | Lakers | 107 |
| December | 2, 2005 | Sonics | 76 | Lakers | 93 |
| December | 5, 2005 | Celtics | 112 | Lakers | 105 |
| December | 6, 2005 | Lakers | 90 | Grizzlies | 88 |
| December | 7, 2005 | Lakers | 113 | Kings | 114 |
| December | 8, 2005 | Lakers | 93 | Sonics | 89 |
| December | 9, 2005 | Lakers | 99 | Jazz | 100 |
| December | 15, 2005 | Lakers | 82 | Magic | 112 |
| December | 20, 2005 | Kings | 97 | Lakers | 119 |
| December | 22, 2005 | Lakers | 92 | Blazers | 89 |
| December | 23, 2005 | Lakers | 94 | Heat | 62 |
| December | 25, 2005 | Grizzlies | 75 | Lakers | 107 |
| December | 27, 2005 | Lakers | 68 | Sonics | 83 |
| December | 31, 2005 | Suns | | Lakers | |
| January | 2, 2006 | Nets | | Lakers | |
| January | 4, 2006 | Clippers | | Lakers | |
| January | 5, 2006 | Lakers | | Hawks | |
| January | 8, 2006 | Heat | | Lakers | |
| January | 12, 2006 | Sonics | | Lakers | |
| January | 13, 2006 | Blazers | | Lakers | |
| January | 14, 2006 | Grizzlies | | Lakers | |
| January | 17, 2006 | Lakers | | Sonics | |
| January | 18, 2006 | Bullets | | Lakers | |
| January | 19, 2006 | Lakers | | Raptors | |
| January | 22, 2006 | Clippers | | Lakers | |
| January | 25, 2006 | Jazz | | Lakers | |
| January | 26, 2006 | Lakers | | Bullets | |
| January | 27, 2006 | Magic | | Lakers | |
| January | 28, 2006 | Spurs | | Lakers | |
| January | 29, 2006 | Wolves | | Lakers | |
| January | 31, 2006 | Bulls | | Lakers | |
| February | 1, 2006 | Cavaliers | | Lakers | |
| February | 2, 2006 | Lakers | | Blazers | |
| February | 8, 2006 | Lakers | | Bucks | |
| February | 10, 2006 | Raptors | | Lakers | |
| February | 11, 2006 | Blazers | | Lakers | |
| February | 12, 2006 | Wolves | | Lakers | |
| February | 13, 2006 | Lakers | | Rockets | |
| February | 16, 2006 | Warriors | | Lakers | |
| February | 17, 2006 | Lakers | | Nuggets | |
| February | 18, 2006 | Suns | | Lakers | |
| February | 20, 2006 | Pacers | | Lakers | |
| February | 21, 2006 | Lakers | | Spurs | |
| February | 24, 2006 | Lakers | | Clippers | |
| February | 26, 2006 | Lakers | | Suns | |
| February | 27, 2006 | Lakers | | Warriors | |
| March | 1, 2006 | Lakers | | 76ers | |
| March | 2, 2006 | Rockets | | Lakers | |
| March | 3, 2006 | Kings | | Lakers | |
| March | 5, 2006 | Lakers | | Rockets | |
| March | 8, 2006 | Mavericks | | Lakers | |
| March | 10, 2006 | Lakers | | Hornets | |
| March | 13, 2006 | Lakers | | Celtics | |
| March | 15, 2006 | Warriors | | Lakers | |
| March | 20, 2006 | Lakers | | Warriors | |
| March | 23, 2006 | Lakers | | Suns | |
| March | 24, 2006 | Lakers | | Wolves | |
| March | 27, 2006 | Lakers | | Jazz | |
| March | 31, 2006 | Lakers | | Nuggets | |
| April | 2, 2006 | Clippers | | Lakers | |
| April | 5, 2006 | Lakers | | Suns | |
| April | 7, 2006 | Spurs | | Lakers | |
| April | 9, 2006 | Pistons | | Lakers | |
| April | 11, 2006 | Hornets | | Lakers | |
| April | 13, 2006 | Knicks | | Lakers | |
| April | 15, 2006 | Lakers | | Cavaliers | |
| April | 16, 2006 | Lakers | | Bulls | |
| April | 17, 2006 | Kings | | Lakers | |
| April | 20, 2006 | Lakers | | Kings | |
| April | 23, 2006 | 76ers | | Lakers | |
| April | 24, 2006 | Rockets | | Lakers | |
| April | 25, 2006 | Lakers | | Mavericks | |