| month | day | visitor | score | home | score |
|---|
| November | 4, 2005 | Cavaliers | 73 | Sonics | 116 |
| November | 6, 2005 | Grizzlies | 91 | Cavaliers | 78 |
| November | 8, 2005 | 76ers | 119 | Cavaliers | 96 |
| November | 9, 2005 | Knicks | 95 | Cavaliers | 82 |
| November | 10, 2005 | Cavaliers | 102 | Pistons | 116 |
| November | 11, 2005 | Cavaliers | 96 | Bulls | 105 |
| November | 13, 2005 | Cavaliers | 94 | 76ers | 118 |
| November | 14, 2005 | Nets | 80 | Cavaliers | 88 |
| November | 15, 2005 | Cavaliers | 83 | Pacers | 103 |
| November | 18, 2005 | Cavaliers | 98 | Kings | 110 |
| November | 19, 2005 | Pistons | 100 | Cavaliers | 89 |
| November | 20, 2005 | Hornets | 100 | Cavaliers | 97 |
| November | 21, 2005 | Raptors | 96 | Cavaliers | 111 |
| November | 22, 2005 | Cavaliers | 99 | Celtics | 125 |
| November | 23, 2005 | Cavaliers | 101 | Bucks | 93 |
| November | 25, 2005 | Cavaliers | 101 | Pacers | 102 |
| November | 26, 2005 | Cavaliers | 110 | Knicks | 129 |
| December | 2, 2005 | Cavaliers | 103 | Hornets | 119 |
| December | 3, 2005 | Nets | 67 | Cavaliers | 93 |
| December | 4, 2005 | Cavaliers | 102 | Blazers | 90 |
| December | 5, 2005 | Wolves | 80 | Cavaliers | 117 |
| December | 6, 2005 | Cavaliers | 98 | Wolves | 109 |
| December | 9, 2005 | Hornets | 125 | Cavaliers | 101 |
| December | 10, 2005 | Cavaliers | 90 | Raptors | 106 |
| December | 17, 2005 | Nuggets | 104 | Cavaliers | 102 |
| December | 19, 2005 | Bullets | 72 | Cavaliers | 97 |
| December | 20, 2005 | Heat | 69 | Cavaliers | 91 |
| December | 26, 2005 | Cavaliers | 84 | Pistons | 108 |
| December | 28, 2005 | Cavaliers | 108 | Raptors | 99 |
| December | 31, 2005 | Cavaliers | | Hawks | |
| January | 1, 2006 | Cavaliers | | Rockets | |
| January | 2, 2006 | Cavaliers | | Mavericks | |
| January | 3, 2006 | Blazers | | Cavaliers | |
| January | 4, 2006 | Cavaliers | | Nets | |
| January | 5, 2006 | Jazz | | Cavaliers | |
| January | 7, 2006 | Cavaliers | | Bucks | |
| January | 8, 2006 | Knicks | | Cavaliers | |
| January | 10, 2006 | Cavaliers | | Grizzlies | |
| January | 13, 2006 | Suns | | Cavaliers | |
| January | 16, 2006 | Pistons | | Cavaliers | |
| January | 19, 2006 | Kings | | Cavaliers | |
| January | 25, 2006 | Hawks | | Cavaliers | |
| January | 27, 2006 | Cavaliers | | Nuggets | |
| January | 31, 2006 | Cavaliers | | Spurs | |
| February | 1, 2006 | Cavaliers | | Lakers | |
| February | 2, 2006 | Cavaliers | | Bullets | |
| February | 4, 2006 | Rockets | | Cavaliers | |
| February | 8, 2006 | Clippers | | Cavaliers | |
| February | 11, 2006 | Pacers | | Cavaliers | |
| February | 14, 2006 | Cavaliers | | Hawks | |
| February | 16, 2006 | Cavaliers | | Suns | |
| February | 19, 2006 | Bucks | | Cavaliers | |
| February | 23, 2006 | Heat | | Cavaliers | |
| February | 25, 2006 | Cavaliers | | Magic | |
| February | 28, 2006 | Pacers | | Cavaliers | |
| March | 4, 2006 | Bulls | | Cavaliers | |
| March | 6, 2006 | Cavaliers | | Jazz | |
| March | 9, 2006 | Cavaliers | | Raptors | |
| March | 12, 2006 | Bucks | | Cavaliers | |
| March | 14, 2006 | Cavaliers | | Hornets | |
| March | 16, 2006 | Cavaliers | | Pacers | |
| March | 18, 2006 | Cavaliers | | 76ers | |
| March | 20, 2006 | Raptors | | Cavaliers | |
| March | 21, 2006 | Spurs | | Cavaliers | |
| March | 22, 2006 | Celtics | | Cavaliers | |
| March | 23, 2006 | Hawks | | Cavaliers | |
| March | 24, 2006 | Warriors | | Cavaliers | |
| March | 25, 2006 | Bulls | | Cavaliers | |
| March | 27, 2006 | Cavaliers | | Pistons | |
| April | 1, 2006 | Bullets | | Cavaliers | |
| April | 3, 2006 | Cavaliers | | Heat | |
| April | 4, 2006 | Sonics | | Cavaliers | |
| April | 5, 2006 | Magic | | Cavaliers | |
| April | 6, 2006 | Cavaliers | | Bulls | |
| April | 7, 2006 | Mavericks | | Cavaliers | |
| April | 10, 2006 | Cavaliers | | Celtics | |
| April | 13, 2006 | Bucks | | Cavaliers | |
| April | 15, 2006 | Lakers | | Cavaliers | |
| April | 18, 2006 | Magic | | Cavaliers | |
| April | 19, 2006 | Cavaliers | | Hornets | |
| April | 21, 2006 | Cavaliers | | Clippers | |
| April | 24, 2006 | Cavaliers | | Warriors | |