| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Knicks | 90 | Hornets | 96 |
| November | 5, 2021 | Suns | 92 | Knicks | 96 |
| November | 8, 2021 | Knicks | 119 | Raptors | 109 |
| November | 12, 2021 | Knicks | 118 | Raptors | 103 |
| November | 13, 2021 | Cavaliers | 101 | Knicks | 119 |
| November | 16, 2021 | Celtics | 111 | Knicks | 107 |
| November | 17, 2021 | Heat | 114 | Knicks | 105 |
| November | 18, 2021 | Knicks | 118 | Timberwolves | 110 |
| November | 20, 2021 | Knicks | 133 | Pistons | 101 |
| November | 22, 2021 | Knicks | 115 | Grizzlies | 117 |
| November | 26, 2021 | Knicks | 95 | Celtics | 116 |
| November | 28, 2021 | Heat | 129 | Knicks | 107 |
| December | 2, 2021 | Knicks | 110 | Rockets | 106 |
| December | 3, 2021 | Clippers | 85 | Knicks | 111 |
| December | 4, 2021 | Hornets | 68 | Knicks | 108 |
| December | 5, 2021 | Knicks | 105 | 76ers | 128 |
| December | 7, 2021 | Knicks | 102 | Grizzlies | 111 |
| December | 8, 2021 | Knicks | 100 | Hornets | 90 |
| December | 10, 2021 | Knicks | 97 | Suns | 101 |
| December | 12, 2021 | Sonics | 103 | Knicks | 113 |
| December | 15, 2021 | Warriors | 96 | Knicks | 105 |
| December | 16, 2021 | Knicks | 109 | Spurs | 108 |
| December | 18, 2021 | Celtics | 127 | Knicks | 114 |
| December | 21, 2021 | Raptors | 105 | Knicks | 108 |
| December | 23, 2021 | Pistons | 104 | Knicks | 106 |
| December | 24, 2021 | Knicks | 106 | 76ers | 109 |
| December | 26, 2021 | Raptors | 118 | Knicks | 116 |
| December | 28, 2021 | 76ers | 103 | Knicks | 104 |
| December | 29, 2021 | Knicks | 107 | 76ers | 95 |
| January | 1, 2022 | Knicks | 110 | Hornets | 96 |
| January | 2, 2022 | Rockets | 97 | Knicks | 125 |
| January | 4, 2022 | 76ers | 118 | Knicks | 116 |
| January | 6, 2022 | Raptors | 107 | Knicks | 128 |
| January | 8, 2022 | Knicks | 118 | Nuggets | 115 |
| January | 10, 2022 | Knicks | 93 | Clippers | 96 |
| January | 12, 2022 | Pistons | 101 | Knicks | 125 |
| January | 13, 2022 | Knicks | 109 | Celtics | 113 |
| January | 15, 2022 | Celtics | 117 | Knicks | 95 |
| January | 16, 2022 | Knicks | 78 | Bulls | 91 |
| January | 17, 2022 | Jazz | 85 | Knicks | 107 |
| January | 19, 2022 | 76ers | 129 | Knicks | 113 |
| January | 23, 2022 | Nuggets | 108 | Knicks | 112 |
| January | 25, 2022 | Knicks | 103 | Lakers | 98 |
| February | 5, 2022 | Knicks | 103 | Raptors | 135 |
| February | 6, 2022 | Spurs | 98 | Knicks | 116 |
| February | 7, 2022 | Knicks | 116 | Cavaliers | 127 |
| February | 9, 2022 | Knicks | 118 | Cavaliers | 105 |
| February | 11, 2022 | Knicks | 114 | Jazz | 99 |
| February | 12, 2022 | Pistons | 85 | Knicks | 110 |
| February | 13, 2022 | Grizzlies | 98 | Knicks | 120 |
| February | 15, 2022 | Hornets | 73 | Knicks | 114 |
| February | 16, 2022 | Grizzlies | 101 | Knicks | 135 |
| February | 19, 2022 | Heat | 111 | Knicks | 99 |
| February | 22, 2022 | Cavaliers | 111 | Knicks | 106 |
| February | 25, 2022 | Knicks | 109 | Sonics | 126 |
| February | 26, 2022 | Pistons | 78 | Knicks | 115 |
| March | 1, 2022 | Grizzlies | 92 | Knicks | 103 |
| March | 2, 2022 | Heat | 143 | Knicks | 120 |
| March | 6, 2022 | Celtics | 124 | Knicks | 117 |
| March | 11, 2022 | Knicks | 103 | Grizzlies | 97 |
| March | 12, 2022 | Knicks | 98 | Cavaliers | 129 |
| March | 14, 2022 | Knicks | 113 | Warriors | 122 |
| March | 16, 2022 | Knicks | 108 | Heat | 123 |
| March | 17, 2022 | Knicks | 74 | Hornets | 88 |
| March | 18, 2022 | Bulls | 113 | Knicks | 108 |
| March | 19, 2022 | 76ers | 108 | Knicks | 139 |
| March | 20, 2022 | Knicks | 90 | Heat | 118 |
| March | 26, 2022 | Knicks | 117 | Cavaliers | 98 |
| March | 27, 2022 | Heat | 122 | Knicks | 115 |
| April | 1, 2022 | Knicks | 113 | Pistons | 107 |
| April | 2, 2022 | Knicks | 82 | Hornets | 85 |
| April | 3, 2022 | Cavaliers | 93 | Knicks | 110 |
| April | 4, 2022 | Knicks | 96 | Bulls | 112 |
| April | 5, 2022 | Knicks | 90 | Bulls | 98 |
| April | 6, 2022 | Knicks | 114 | Celtics | 104 |
| April | 10, 2022 | Bulls | 95 | Knicks | 97 |
| April | 11, 2022 | Grizzlies | 99 | Knicks | 118 |
| April | 12, 2022 | Knicks | 108 | Raptors | 124 |
| April | 13, 2022 | Knicks | 92 | Bulls | 99 |
| April | 14, 2022 | Lakers | 85 | Knicks | 133 |
| April | 15, 2022 | Knicks | 97 | Pistons | 110 |
| April | 17, 2022 | Timberwolves | 107 | Knicks | 116 |
| Post | 1, 2022 | Knicks | 118 | 76ers | 126 |
| Post | 2, 2022 | Knicks | 89 | 76ers | 119 |
| Post | 3, 2022 | 76ers | 91 | Knicks | 105 |
| Post | 4, 2022 | 76ers | 115 | Knicks | 100 |
| Post | 5, 2022 | Knicks | 94 | 76ers | 110 |
| Post | 6, 2022 | 76ers | | Knicks | |
| Post | 7, 2022 | Knicks | | 76ers | |