| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Spurs | 90 | Celtics | 123 |
| November | 3, 2021 | Cavaliers | 118 | Celtics | 144 |
| November | 4, 2021 | Heat | 117 | Celtics | 97 |
| November | 5, 2021 | Celtics | 111 | Clippers | 123 |
| November | 7, 2021 | Pistons | 104 | Celtics | 117 |
| November | 9, 2021 | Sonics | 106 | Celtics | 110 |
| November | 13, 2021 | Celtics | 110 | Suns | 105 |
| November | 14, 2021 | Celtics | 109 | Heat | 127 |
| November | 16, 2021 | Celtics | 111 | Knicks | 107 |
| November | 18, 2021 | Bulls | 102 | Celtics | 98 |
| November | 19, 2021 | Celtics | 100 | Bulls | 109 |
| November | 24, 2021 | Celtics | 101 | Hornets | 96 |
| November | 25, 2021 | Hornets | 86 | Celtics | 116 |
| November | 26, 2021 | Knicks | 95 | Celtics | 116 |
| November | 27, 2021 | Rockets | 104 | Celtics | 120 |
| November | 28, 2021 | Celtics | 105 | Cavaliers | 95 |
| November | 29, 2021 | Raptors | 119 | Celtics | 108 |
| November | 30, 2021 | 76ers | 94 | Celtics | 128 |
| December | 2, 2021 | 76ers | 104 | Celtics | 117 |
| December | 3, 2021 | Celtics | 104 | Raptors | 107 |
| December | 5, 2021 | Celtics | 120 | Grizzlies | 121 |
| December | 6, 2021 | Celtics | 100 | Rockets | 104 |
| December | 10, 2021 | Celtics | 122 | Nuggets | 115 |
| December | 16, 2021 | Celtics | 118 | Cavaliers | 99 |
| December | 18, 2021 | Celtics | 127 | Knicks | 114 |
| December | 19, 2021 | Bulls | 106 | Celtics | 108 |
| December | 22, 2021 | Heat | 131 | Celtics | 123 |
| December | 24, 2021 | Hornets | 104 | Celtics | 138 |
| December | 25, 2021 | Celtics | 100 | Heat | 133 |
| December | 30, 2021 | Suns | 120 | Celtics | 128 |
| January | 2, 2022 | Celtics | 97 | Hornets | 83 |
| January | 3, 2022 | Celtics | 111 | Raptors | 107 |
| January | 4, 2022 | Grizzlies | 106 | Celtics | 118 |
| January | 8, 2022 | Pistons | 93 | Celtics | 126 |
| January | 9, 2022 | Celtics | 101 | Hornets | 85 |
| January | 10, 2022 | Grizzlies | 103 | Celtics | 114 |
| January | 11, 2022 | Hornets | 73 | Celtics | 96 |
| January | 13, 2022 | Knicks | 109 | Celtics | 113 |
| January | 15, 2022 | Celtics | 117 | Knicks | 95 |
| January | 16, 2022 | Celtics | 111 | Grizzlies | 107 |
| January | 19, 2022 | Cavaliers | 95 | Celtics | 125 |
| January | 22, 2022 | 76ers | 108 | Celtics | 95 |
| January | 23, 2022 | Celtics | 113 | Timberwolves | 124 |
| January | 25, 2022 | Celtics | 115 | Heat | 120 |
| January | 26, 2022 | Celtics | 129 | Heat | 126 |
| January | 28, 2022 | Celtics | 106 | 76ers | 82 |
| February | 5, 2022 | Warriors | 102 | Celtics | 128 |
| February | 7, 2022 | Nuggets | 97 | Celtics | 120 |
| February | 8, 2022 | Celtics | 102 | Grizzlies | 105 |
| February | 10, 2022 | Celtics | 95 | Bulls | 98 |
| February | 11, 2022 | Celtics | 125 | 76ers | 117 |
| February | 14, 2022 | Raptors | 118 | Celtics | 107 |
| February | 15, 2022 | Pistons | 92 | Celtics | 136 |
| February | 16, 2022 | Raptors | 136 | Celtics | 131 |
| February | 18, 2022 | Celtics | 126 | Lakers | 110 |
| February | 19, 2022 | Raptors | 99 | Celtics | 109 |
| February | 21, 2022 | Celtics | 106 | Jazz | 99 |
| February | 23, 2022 | Celtics | 113 | Pistons | 115 |
| February | 25, 2022 | Bulls | 87 | Celtics | 102 |
| March | 2, 2022 | Grizzlies | 93 | Celtics | 125 |
| March | 3, 2022 | Celtics | 118 | Raptors | 106 |
| March | 6, 2022 | Celtics | 124 | Knicks | 117 |
| March | 7, 2022 | Celtics | 105 | Heat | 120 |
| March | 8, 2022 | Celtics | 112 | Warriors | 118 |
| March | 9, 2022 | Celtics | 107 | Sonics | 109 |
| March | 11, 2022 | Lakers | 83 | Celtics | 141 |
| March | 12, 2022 | Celtics | 122 | Bulls | 97 |
| March | 15, 2022 | Celtics | 92 | Hornets | 87 |
| March | 19, 2022 | Celtics | 106 | Pistons | 105 |
| March | 23, 2022 | Hornets | 80 | Celtics | 90 |
| March | 26, 2022 | Celtics | 120 | 76ers | 126 |
| March | 29, 2022 | Cavaliers | 104 | Celtics | 125 |
| April | 1, 2022 | Celtics | 93 | Spurs | 89 |
| April | 6, 2022 | Knicks | 114 | Celtics | 104 |
| April | 7, 2022 | 76ers | 119 | Celtics | 105 |
| April | 8, 2022 | Jazz | 90 | Celtics | 112 |
| April | 10, 2022 | Cavaliers | 86 | Celtics | 134 |
| April | 11, 2022 | Bulls | 103 | Celtics | 105 |
| April | 14, 2022 | Timberwolves | 71 | Celtics | 117 |
| April | 16, 2022 | Celtics | 98 | Pistons | 117 |
| April | 17, 2022 | Celtics | 110 | Cavaliers | 104 |
| April | 19, 2022 | Clippers | 107 | Celtics | 110 |
| Post | 1, 2022 | Raptors | 83 | Celtics | 107 |
| Post | 2, 2022 | Raptors | 113 | Celtics | 114 |
| Post | 3, 2022 | Celtics | 100 | Raptors | 107 |
| Post | 4, 2022 | Celtics | 101 | Raptors | 112 |
| Post | 5, 2022 | Raptors | 105 | Celtics | 120 |
| Post | 6, 2022 | Celtics | 117 | Raptors | 112 |
| Post | 7, 2022 | Raptors | | Celtics | |
| Post | 8, 2022 | Celtics | 98 | Bulls | 95 |
| Post | 9, 2022 | Celtics | 100 | Bulls | 82 |
| Post | 10, 2022 | Bulls | 80 | Celtics | 101 |
| Post | 11, 2022 | Bulls | 87 | Celtics | 98 |
| Post | 12, 2022 | Celtics | | Bulls | |
| Post | 13, 2022 | Bulls | | Celtics | |
| Post | 14, 2022 | Celtics | | Bulls | |
| Post | 15, 2022 | Celtics | 90 | Heat | 116 |
| Post | 16, 2022 | Celtics | 104 | Heat | 114 |
| Post | 17, 2022 | Heat | 100 | Celtics | 104 |
| Post | 18, 2022 | Heat | 92 | Celtics | 117 |
| Post | 19, 2022 | Celtics | 108 | Heat | 112 |
| Post | 20, 2022 | Heat | 105 | Celtics | 98 |
| Post | 21, 2022 | Celtics | | Heat | |