| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Warriors | 121 | Timberwolves | 113 |
| November | 4, 2020 | Clippers | 94 | Timberwolves | 102 |
| November | 6, 2020 | Timberwolves | 101 | Rockets | 105 |
| November | 9, 2020 | Jazz | 97 | Timberwolves | 83 |
| November | 10, 2020 | Timberwolves | 102 | Nuggets | 82 |
| November | 12, 2020 | Timberwolves | 102 | Warriors | 125 |
| November | 16, 2020 | Timberwolves | 90 | Suns | 97 |
| November | 17, 2020 | Timberwolves | 100 | Lakers | 114 |
| November | 18, 2020 | Knicks | 100 | Timberwolves | 90 |
| November | 19, 2020 | Pistons | 118 | Timberwolves | 115 |
| November | 20, 2020 | Nuggets | 93 | Timberwolves | 103 |
| November | 23, 2020 | Nuggets | 84 | Timberwolves | 108 |
| November | 27, 2020 | Clippers | 71 | Timberwolves | 93 |
| November | 30, 2020 | Clippers | 92 | Timberwolves | 90 |
| December | 3, 2020 | Lakers | 108 | Timberwolves | 112 |
| December | 4, 2020 | Timberwolves | 86 | Sonics | 108 |
| December | 5, 2020 | Timberwolves | 94 | Spurs | 99 |
| December | 11, 2020 | Timberwolves | 87 | Jazz | 97 |
| December | 12, 2020 | Timberwolves | 127 | Lakers | 109 |
| December | 13, 2020 | Timberwolves | 101 | Nuggets | 109 |
| December | 14, 2020 | Timberwolves | 115 | Spurs | 100 |
| December | 16, 2020 | Timberwolves | 77 | Clippers | 120 |
| December | 17, 2020 | Timberwolves | 85 | Bulls | 86 |
| December | 19, 2020 | Timberwolves | 85 | Jazz | 90 |
| December | 20, 2020 | Spurs | 91 | Timberwolves | 93 |
| December | 21, 2020 | Timberwolves | 100 | Heat | 142 |
| December | 22, 2020 | Timberwolves | 92 | Pistons | 118 |
| December | 24, 2020 | Jazz | 99 | Timberwolves | 78 |
| December | 25, 2020 | Suns | 92 | Timberwolves | 102 |
| December | 26, 2020 | Warriors | 125 | Timberwolves | 96 |
| January | 2, 2021 | Timberwolves | 97 | Nuggets | 119 |
| January | 3, 2021 | Timberwolves | 82 | Spurs | 92 |
| January | 5, 2021 | Rockets | 111 | Timberwolves | 102 |
| January | 10, 2021 | Suns | 101 | Timberwolves | 96 |
| January | 12, 2021 | Timberwolves | 84 | Clippers | 120 |
| January | 15, 2021 | Timberwolves | 90 | Suns | 108 |
| January | 19, 2021 | Timberwolves | 104 | Rockets | 123 |
| January | 20, 2021 | Jazz | 97 | Timberwolves | 82 |
| January | 21, 2021 | Timberwolves | 92 | Hornets | 126 |
| January | 22, 2021 | Timberwolves | 92 | Sonics | 128 |
| January | 23, 2021 | Celtics | 125 | Timberwolves | 102 |
| January | 24, 2021 | Rockets | 100 | Timberwolves | 97 |
| January | 26, 2021 | Timberwolves | 94 | Spurs | 112 |
| January | 28, 2021 | Timberwolves | 105 | Lakers | 106 |
| January | 30, 2021 | Nuggets | 99 | Timberwolves | 100 |
| January | 31, 2021 | Timberwolves | 104 | Jazz | 102 |
| February | 5, 2021 | Spurs | 92 | Timberwolves | 108 |
| February | 7, 2021 | Clippers | 92 | Timberwolves | 97 |
| February | 8, 2021 | 76ers | 134 | Timberwolves | 104 |
| February | 10, 2021 | Hornets | 117 | Timberwolves | 102 |
| February | 11, 2021 | Lakers | 103 | Timberwolves | 119 |
| February | 12, 2021 | Sonics | 118 | Timberwolves | 80 |
| February | 14, 2021 | Bulls | 81 | Timberwolves | 88 |
| February | 17, 2021 | Timberwolves | 86 | Suns | 92 |
| February | 18, 2021 | Timberwolves | 96 | Warriors | 109 |
| February | 23, 2021 | Jazz | 110 | Timberwolves | 84 |
| February | 24, 2021 | Timberwolves | 94 | Raptors | 118 |
| February | 26, 2021 | Rockets | 105 | Timberwolves | 107 |
| February | 27, 2021 | Timberwolves | 90 | Jazz | 85 |
| March | 2, 2021 | Timberwolves | 97 | Warriors | 125 |
| March | 3, 2021 | Timberwolves | 87 | Cavaliers | 102 |
| March | 4, 2021 | Sonics | 122 | Timberwolves | 107 |
| March | 7, 2021 | Timberwolves | 108 | 76ers | 129 |
| March | 11, 2021 | Cavaliers | 100 | Timberwolves | 88 |
| March | 12, 2021 | Timberwolves | 82 | Rockets | 123 |
| March | 15, 2021 | Lakers | 118 | Timberwolves | 115 |
| March | 16, 2021 | Timberwolves | 90 | Rockets | 103 |
| March | 19, 2021 | Sonics | 124 | Timberwolves | 101 |
| March | 21, 2021 | Timberwolves | 99 | Sonics | 125 |
| March | 22, 2021 | Lakers | 111 | Timberwolves | 114 |
| March | 23, 2021 | Grizzlies | 87 | Timberwolves | 79 |
| March | 25, 2021 | Warriors | 109 | Timberwolves | 104 |
| March | 28, 2021 | Heat | 121 | Timberwolves | 99 |
| March | 29, 2021 | Timberwolves | 75 | Grizzlies | 74 |
| April | 1, 2021 | Suns | 87 | Timberwolves | 101 |
| April | 3, 2021 | Raptors | 85 | Timberwolves | 93 |
| April | 9, 2021 | Timberwolves | 107 | Clippers | 106 |
| April | 12, 2021 | Sonics | 125 | Timberwolves | 110 |
| April | 14, 2021 | Timberwolves | 87 | Celtics | 112 |
| April | 16, 2021 | Spurs | 91 | Timberwolves | 103 |
| April | 17, 2021 | Timberwolves | 85 | Knicks | 121 |
| April | 20, 2021 | Timberwolves | 80 | Nuggets | 106 |