| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Spurs | 94 | Celtics | 105 |
| November | 3, 2020 | Spurs | 111 | Jazz | 103 |
| November | 7, 2020 | Spurs | 116 | Rockets | 109 |
| November | 8, 2020 | Nuggets | 99 | Spurs | 114 |
| November | 10, 2020 | Spurs | 109 | Suns | 97 |
| November | 12, 2020 | Spurs | 98 | Rockets | 101 |
| November | 13, 2020 | Spurs | 111 | Jazz | 110 |
| November | 14, 2020 | Rockets | 95 | Spurs | 90 |
| November | 18, 2020 | Spurs | 110 | Nuggets | 108 |
| November | 21, 2020 | Spurs | 97 | Grizzlies | 101 |
| November | 27, 2020 | Spurs | 85 | Jazz | 100 |
| November | 29, 2020 | Spurs | 77 | Suns | 89 |
| November | 30, 2020 | Spurs | 97 | Pistons | 115 |
| December | 2, 2020 | Spurs | 101 | Nuggets | 83 |
| December | 5, 2020 | Timberwolves | 94 | Spurs | 99 |
| December | 6, 2020 | Spurs | 109 | Lakers | 116 |
| December | 7, 2020 | Rockets | 83 | Spurs | 95 |
| December | 9, 2020 | Sonics | 132 | Spurs | 123 |
| December | 10, 2020 | Jazz | 95 | Spurs | 92 |
| December | 11, 2020 | Rockets | 92 | Spurs | 79 |
| December | 12, 2020 | Suns | 111 | Spurs | 110 |
| December | 14, 2020 | Timberwolves | 115 | Spurs | 100 |
| December | 15, 2020 | Rockets | 85 | Spurs | 110 |
| December | 16, 2020 | Knicks | 102 | Spurs | 110 |
| December | 17, 2020 | Lakers | 90 | Spurs | 125 |
| December | 18, 2020 | 76ers | 109 | Spurs | 100 |
| December | 19, 2020 | Spurs | 111 | Sonics | 113 |
| December | 20, 2020 | Spurs | 91 | Timberwolves | 93 |
| December | 25, 2020 | Spurs | 92 | Clippers | 91 |
| December | 26, 2020 | Spurs | 106 | Jazz | 89 |
| December | 29, 2020 | Spurs | 90 | Nuggets | 98 |
| December | 30, 2020 | Clippers | 84 | Spurs | 96 |
| December | 31, 2020 | Lakers | 100 | Spurs | 101 |
| January | 3, 2021 | Timberwolves | 82 | Spurs | 92 |
| January | 7, 2021 | Spurs | 87 | Nuggets | 106 |
| January | 8, 2021 | Spurs | 106 | Clippers | 93 |
| January | 9, 2021 | Lakers | 111 | Spurs | 92 |
| January | 11, 2021 | Heat | 108 | Spurs | 92 |
| January | 12, 2021 | Spurs | 102 | Sonics | 105 |
| January | 19, 2021 | Raptors | 88 | Spurs | 94 |
| January | 23, 2021 | Warriors | 119 | Spurs | 117 |
| January | 24, 2021 | Spurs | 117 | 76ers | 116 |
| January | 25, 2021 | Cavaliers | 108 | Spurs | 96 |
| January | 26, 2021 | Timberwolves | 94 | Spurs | 112 |
| February | 5, 2021 | Spurs | 92 | Timberwolves | 108 |
| February | 6, 2021 | Spurs | 73 | Knicks | 110 |
| February | 9, 2021 | Jazz | 110 | Spurs | 100 |
| February | 12, 2021 | Grizzlies | 96 | Spurs | 111 |
| February | 15, 2021 | Sonics | 115 | Spurs | 124 |
| February | 16, 2021 | Spurs | 94 | Lakers | 117 |
| February | 18, 2021 | Bulls | 81 | Spurs | 87 |
| February | 20, 2021 | Warriors | 123 | Spurs | 116 |
| February | 21, 2021 | Rockets | 100 | Spurs | 108 |
| February | 22, 2021 | Spurs | 103 | Hornets | 106 |
| February | 24, 2021 | Pistons | 111 | Spurs | 116 |
| February | 26, 2021 | Hornets | 92 | Spurs | 105 |
| February | 28, 2021 | Nuggets | 106 | Spurs | 111 |
| March | 1, 2021 | Spurs | 111 | Warriors | 117 |
| March | 3, 2021 | Jazz | 107 | Spurs | 96 |
| March | 4, 2021 | Spurs | 113 | Heat | 125 |
| March | 5, 2021 | Clippers | 100 | Spurs | 107 |
| March | 7, 2021 | Suns | 101 | Spurs | 89 |
| March | 8, 2021 | Lakers | 108 | Spurs | 118 |
| March | 10, 2021 | Spurs | 92 | Nuggets | 107 |
| March | 11, 2021 | Sonics | 115 | Spurs | 110 |
| March | 15, 2021 | Sonics | 113 | Spurs | 109 |
| March | 18, 2021 | Suns | 82 | Spurs | 99 |
| March | 19, 2021 | Warriors | 123 | Spurs | 113 |
| March | 20, 2021 | Spurs | 97 | Raptors | 126 |
| March | 22, 2021 | Spurs | 95 | Warriors | 126 |
| March | 24, 2021 | Spurs | 88 | Bulls | 102 |
| March | 29, 2021 | Spurs | 86 | Jazz | 85 |
| March | 31, 2021 | Spurs | 107 | Warriors | 103 |
| April | 1, 2021 | Celtics | 119 | Spurs | 77 |
| April | 2, 2021 | Spurs | 105 | Sonics | 124 |
| April | 6, 2021 | Suns | 102 | Spurs | 97 |
| April | 8, 2021 | Spurs | 92 | Clippers | 90 |
| April | 9, 2021 | Spurs | 84 | Suns | 85 |
| April | 11, 2021 | Spurs | 97 | Clippers | 91 |
| April | 16, 2021 | Spurs | 91 | Timberwolves | 103 |
| April | 18, 2021 | Spurs | 72 | Cavaliers | 103 |
| April | 20, 2021 | Spurs | 103 | Lakers | 109 |
| Post | 1, 2021 | Spurs | 81 | Rockets | 77 |
| Post | 2, 2021 | Spurs | 85 | Rockets | 103 |
| Post | 3, 2021 | Rockets | 80 | Spurs | 85 |
| Post | 4, 2021 | Rockets | 86 | Spurs | 92 |
| Post | 5, 2021 | Spurs | 103 | Rockets | 92 |
| Post | 6, 2021 | Rockets | | Spurs | |
| Post | 7, 2021 | Spurs | | Rockets | |
| Post | 8, 2021 | Spurs | 88 | Sonics | 113 |
| Post | 9, 2021 | Spurs | 113 | Sonics | 114 |
| Post | 10, 2021 | Sonics | 107 | Spurs | 118 |
| Post | 11, 2021 | Sonics | 104 | Spurs | 99 |
| Post | 12, 2021 | Spurs | 110 | Sonics | 134 |
| Post | 13, 2021 | Sonics | | Spurs | |
| Post | 14, 2021 | Spurs | | Sonics | |