| month | day | visitor | score | home | score |
|---|
| November | 5, 2020 | Warriors | 125 | Rockets | 126 |
| November | 6, 2020 | Timberwolves | 101 | Rockets | 105 |
| November | 7, 2020 | Spurs | 116 | Rockets | 109 |
| November | 10, 2020 | Warriors | 104 | Rockets | 115 |
| November | 11, 2020 | Rockets | 100 | Clippers | 88 |
| November | 12, 2020 | Spurs | 98 | Rockets | 101 |
| November | 14, 2020 | Rockets | 95 | Spurs | 90 |
| November | 16, 2020 | Jazz | 96 | Rockets | 84 |
| November | 19, 2020 | Nuggets | 105 | Rockets | 132 |
| November | 21, 2020 | Lakers | 116 | Rockets | 119 |
| November | 22, 2020 | Clippers | 99 | Rockets | 95 |
| November | 25, 2020 | Warriors | 133 | Rockets | 103 |
| November | 27, 2020 | Rockets | 78 | Celtics | 91 |
| November | 30, 2020 | Rockets | 85 | Sonics | 120 |
| December | 1, 2020 | Rockets | 101 | Nuggets | 92 |
| December | 2, 2020 | Knicks | 108 | Rockets | 114 |
| December | 3, 2020 | Rockets | 89 | Suns | 128 |
| December | 4, 2020 | Rockets | 122 | Lakers | 110 |
| December | 6, 2020 | Celtics | 102 | Rockets | 84 |
| December | 7, 2020 | Rockets | 83 | Spurs | 95 |
| December | 9, 2020 | 76ers | 109 | Rockets | 96 |
| December | 11, 2020 | Rockets | 92 | Spurs | 79 |
| December | 15, 2020 | Rockets | 85 | Spurs | 110 |
| December | 17, 2020 | Sonics | 107 | Rockets | 120 |
| December | 19, 2020 | Rockets | 107 | Nuggets | 89 |
| December | 20, 2020 | Grizzlies | 122 | Rockets | 108 |
| December | 23, 2020 | Rockets | 118 | Heat | 114 |
| December | 24, 2020 | Bulls | 76 | Rockets | 98 |
| December | 25, 2020 | Rockets | 103 | Hornets | 91 |
| December | 27, 2020 | Rockets | 110 | Lakers | 131 |
| January | 1, 2021 | Rockets | 100 | Jazz | 114 |
| January | 2, 2021 | Rockets | 95 | Knicks | 126 |
| January | 5, 2021 | Rockets | 111 | Timberwolves | 102 |
| January | 6, 2021 | Suns | 86 | Rockets | 111 |
| January | 10, 2021 | Rockets | 144 | Pistons | 130 |
| January | 13, 2021 | Hornets | 123 | Rockets | 118 |
| January | 14, 2021 | Sonics | 111 | Rockets | 97 |
| January | 18, 2021 | Rockets | 124 | Warriors | 97 |
| January | 19, 2021 | Timberwolves | 104 | Rockets | 123 |
| January | 20, 2021 | Raptors | 90 | Rockets | 94 |
| January | 23, 2021 | Rockets | 111 | Sonics | 117 |
| January | 24, 2021 | Rockets | 100 | Timberwolves | 97 |
| January | 26, 2021 | Rockets | 96 | Nuggets | 108 |
| January | 27, 2021 | Clippers | 87 | Rockets | 107 |
| January | 28, 2021 | Rockets | 98 | Sonics | 114 |
| February | 5, 2021 | Rockets | 78 | Jazz | 85 |
| February | 6, 2021 | Rockets | 97 | Warriors | 113 |
| February | 12, 2021 | Suns | 106 | Rockets | 83 |
| February | 14, 2021 | Rockets | 99 | Clippers | 97 |
| February | 16, 2021 | Jazz | 96 | Rockets | 94 |
| February | 19, 2021 | Lakers | 95 | Rockets | 116 |
| February | 20, 2021 | Nuggets | 109 | Rockets | 91 |
| February | 21, 2021 | Rockets | 100 | Spurs | 108 |
| February | 24, 2021 | Nuggets | 106 | Rockets | 98 |
| February | 26, 2021 | Rockets | 105 | Timberwolves | 107 |
| February | 28, 2021 | Clippers | 106 | Rockets | 109 |
| March | 4, 2021 | Clippers | 93 | Rockets | 96 |
| March | 5, 2021 | Rockets | 103 | Nuggets | 96 |
| March | 6, 2021 | Lakers | 124 | Rockets | 115 |
| March | 7, 2021 | Rockets | 114 | Warriors | 102 |
| March | 8, 2021 | Sonics | 118 | Rockets | 100 |
| March | 9, 2021 | Rockets | 92 | Cavaliers | 108 |
| March | 12, 2021 | Timberwolves | 82 | Rockets | 123 |
| March | 13, 2021 | Heat | 117 | Rockets | 120 |
| March | 14, 2021 | Rockets | 104 | Jazz | 83 |
| March | 16, 2021 | Timberwolves | 90 | Rockets | 103 |
| March | 20, 2021 | Rockets | 89 | Clippers | 113 |
| March | 22, 2021 | Rockets | 87 | Suns | 86 |
| March | 24, 2021 | Rockets | 85 | Suns | 99 |
| March | 25, 2021 | Pistons | 120 | Rockets | 111 |
| March | 28, 2021 | Rockets | 104 | Grizzlies | 95 |
| March | 30, 2021 | Cavaliers | 111 | Rockets | 95 |
| April | 2, 2021 | Jazz | 108 | Rockets | 76 |
| April | 3, 2021 | Rockets | 69 | Jazz | 101 |
| April | 4, 2021 | Sonics | 110 | Rockets | 103 |
| April | 5, 2021 | Rockets | 66 | Raptors | 96 |
| April | 7, 2021 | Rockets | 80 | Lakers | 116 |
| April | 8, 2021 | Lakers | 126 | Rockets | 108 |
| April | 9, 2021 | Rockets | 85 | 76ers | 121 |
| April | 12, 2021 | Rockets | 78 | Bulls | 115 |
| April | 17, 2021 | Jazz | 91 | Rockets | 71 |
| April | 19, 2021 | Suns | 100 | Rockets | 85 |
| Post | 1, 2021 | Spurs | 81 | Rockets | 77 |
| Post | 2, 2021 | Spurs | 85 | Rockets | 103 |
| Post | 3, 2021 | Rockets | 80 | Spurs | 85 |
| Post | 4, 2021 | Rockets | 86 | Spurs | 92 |
| Post | 5, 2021 | Spurs | 103 | Rockets | 92 |
| Post | 6, 2021 | Rockets | | Spurs | |
| Post | 7, 2021 | Spurs | | Rockets | |