| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Pistons | 92 | Raptors | 103 |
| November | 4, 2020 | Pistons | 93 | Raptors | 100 |
| November | 7, 2020 | Grizzlies | 108 | Raptors | 97 |
| November | 8, 2020 | Knicks | 96 | Raptors | 115 |
| November | 9, 2020 | Heat | 105 | Raptors | 111 |
| November | 12, 2020 | Knicks | 76 | Raptors | 111 |
| November | 13, 2020 | Raptors | 102 | Warriors | 133 |
| November | 15, 2020 | Raptors | 108 | Cavaliers | 106 |
| November | 17, 2020 | Raptors | 96 | Cavaliers | 105 |
| November | 19, 2020 | Raptors | 85 | Clippers | 97 |
| November | 20, 2020 | Warriors | 105 | Raptors | 119 |
| November | 22, 2020 | Bulls | 89 | Raptors | 78 |
| November | 23, 2020 | Raptors | 102 | 76ers | 120 |
| November | 26, 2020 | Raptors | 100 | Pistons | 117 |
| November | 27, 2020 | Lakers | 111 | Raptors | 100 |
| November | 29, 2020 | Raptors | 79 | Celtics | 93 |
| December | 1, 2020 | Raptors | 105 | Pistons | 109 |
| December | 2, 2020 | Cavaliers | 123 | Raptors | 131 |
| December | 3, 2020 | Celtics | 88 | Raptors | 78 |
| December | 7, 2020 | Cavaliers | 109 | Raptors | 113 |
| December | 9, 2020 | Raptors | 109 | Pistons | 112 |
| December | 11, 2020 | Raptors | 112 | 76ers | 115 |
| December | 13, 2020 | Bulls | 101 | Raptors | 89 |
| December | 15, 2020 | Raptors | 106 | Hornets | 100 |
| December | 21, 2020 | Raptors | 119 | Knicks | 116 |
| December | 23, 2020 | Hornets | 112 | Raptors | 115 |
| December | 26, 2020 | Raptors | 102 | Knicks | 145 |
| December | 28, 2020 | Raptors | 109 | Bulls | 104 |
| December | 30, 2020 | Nuggets | 99 | Raptors | 122 |
| January | 3, 2021 | Celtics | 94 | Raptors | 110 |
| January | 5, 2021 | Raptors | 93 | Heat | 110 |
| January | 6, 2021 | Raptors | 119 | Knicks | 135 |
| January | 7, 2021 | Pistons | 112 | Raptors | 133 |
| January | 9, 2021 | Heat | 131 | Raptors | 122 |
| January | 10, 2021 | Jazz | 75 | Raptors | 103 |
| January | 11, 2021 | Raptors | 106 | Nuggets | 109 |
| January | 12, 2021 | 76ers | 133 | Raptors | 123 |
| January | 17, 2021 | Raptors | 87 | Pistons | 120 |
| January | 18, 2021 | Grizzlies | 91 | Raptors | 105 |
| January | 19, 2021 | Raptors | 88 | Spurs | 94 |
| January | 20, 2021 | Raptors | 90 | Rockets | 94 |
| January | 23, 2021 | Heat | 133 | Raptors | 113 |
| January | 25, 2021 | Raptors | 86 | Jazz | 95 |
| January | 28, 2021 | Raptors | 116 | Heat | 119 |
| February | 5, 2021 | Knicks | 116 | Raptors | 135 |
| February | 10, 2021 | Cavaliers | 94 | Raptors | 120 |
| February | 13, 2021 | Raptors | 87 | Bulls | 98 |
| February | 14, 2021 | Raptors | 96 | Celtics | 103 |
| February | 16, 2021 | Raptors | 101 | Celtics | 105 |
| February | 19, 2021 | Raptors | 103 | Celtics | 104 |
| February | 20, 2021 | Raptors | 99 | Grizzlies | 100 |
| February | 23, 2021 | Raptors | 90 | Hornets | 119 |
| February | 24, 2021 | Timberwolves | 94 | Raptors | 118 |
| February | 25, 2021 | Raptors | 98 | Grizzlies | 82 |
| February | 26, 2021 | 76ers | 112 | Raptors | 120 |
| March | 1, 2021 | Hornets | 121 | Raptors | 119 |
| March | 3, 2021 | Celtics | 107 | Raptors | 104 |
| March | 4, 2021 | 76ers | 117 | Raptors | 108 |
| March | 5, 2021 | Raptors | 102 | Heat | 122 |
| March | 7, 2021 | Raptors | 96 | Cavaliers | 111 |
| March | 16, 2021 | Hornets | 91 | Raptors | 99 |
| March | 17, 2021 | Raptors | 131 | Lakers | 93 |
| March | 18, 2021 | Raptors | 99 | 76ers | 115 |
| March | 20, 2021 | Spurs | 97 | Raptors | 126 |
| March | 21, 2021 | Raptors | 102 | Grizzlies | 82 |
| March | 23, 2021 | Raptors | 91 | Bulls | 95 |
| March | 25, 2021 | Bulls | 82 | Raptors | 83 |
| March | 26, 2021 | Hornets | 130 | Raptors | 109 |
| March | 27, 2021 | Grizzlies | 102 | Raptors | 104 |
| March | 29, 2021 | Suns | 80 | Raptors | 91 |
| March | 31, 2021 | Sonics | 120 | Raptors | 118 |
| April | 2, 2021 | Raptors | 106 | Grizzlies | 78 |
| April | 3, 2021 | Raptors | 85 | Timberwolves | 93 |
| April | 4, 2021 | Clippers | 108 | Raptors | 120 |
| April | 5, 2021 | Rockets | 66 | Raptors | 96 |
| April | 6, 2021 | Cavaliers | 95 | Raptors | 104 |
| April | 7, 2021 | Bulls | 100 | Raptors | 113 |
| April | 10, 2021 | Raptors | 94 | Heat | 129 |
| April | 12, 2021 | Knicks | 134 | Raptors | 96 |
| April | 13, 2021 | Raptors | 102 | Suns | 97 |
| April | 18, 2021 | Raptors | 106 | 76ers | 108 |
| April | 19, 2021 | Raptors | 110 | Sonics | 115 |