| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Pistons | 122 | Lakers | 99 |
| November | 3, 2020 | Pistons | 92 | Raptors | 103 |
| November | 4, 2020 | Pistons | 93 | Raptors | 100 |
| November | 6, 2020 | Pistons | 102 | Suns | 75 |
| November | 7, 2020 | Pistons | 100 | Celtics | 90 |
| November | 10, 2020 | Pistons | 99 | Bulls | 106 |
| November | 11, 2020 | Bulls | 97 | Pistons | 100 |
| November | 12, 2020 | Pistons | 91 | Grizzlies | 108 |
| November | 15, 2020 | Pistons | 93 | 76ers | 97 |
| November | 19, 2020 | Pistons | 118 | Timberwolves | 115 |
| November | 20, 2020 | Knicks | 111 | Pistons | 124 |
| November | 22, 2020 | Pistons | 99 | Jazz | 115 |
| November | 23, 2020 | Pistons | 86 | Heat | 122 |
| November | 24, 2020 | Pistons | 94 | Heat | 134 |
| November | 26, 2020 | Raptors | 100 | Pistons | 117 |
| November | 28, 2020 | Hornets | 110 | Pistons | 116 |
| November | 29, 2020 | Cavaliers | 98 | Pistons | 107 |
| November | 30, 2020 | Spurs | 97 | Pistons | 115 |
| December | 1, 2020 | Raptors | 105 | Pistons | 109 |
| December | 6, 2020 | 76ers | 97 | Pistons | 109 |
| December | 7, 2020 | Heat | 122 | Pistons | 95 |
| December | 8, 2020 | Pistons | 106 | 76ers | 107 |
| December | 9, 2020 | Raptors | 109 | Pistons | 112 |
| December | 10, 2020 | 76ers | 108 | Pistons | 114 |
| December | 11, 2020 | Cavaliers | 106 | Pistons | 91 |
| December | 14, 2020 | Pistons | 102 | Hornets | 122 |
| December | 21, 2020 | Pistons | 90 | Grizzlies | 104 |
| December | 22, 2020 | Timberwolves | 92 | Pistons | 118 |
| December | 23, 2020 | Pistons | 104 | Knicks | 118 |
| December | 25, 2020 | Bulls | 110 | Pistons | 119 |
| December | 27, 2020 | Pistons | 97 | Bulls | 64 |
| December | 31, 2020 | Pistons | 93 | Sonics | 107 |
| January | 2, 2021 | Pistons | 109 | Grizzlies | 90 |
| January | 3, 2021 | Pistons | 94 | Heat | 111 |
| January | 4, 2021 | Pistons | 95 | Cavaliers | 108 |
| January | 5, 2021 | Grizzlies | 96 | Pistons | 125 |
| January | 7, 2021 | Pistons | 112 | Raptors | 133 |
| January | 8, 2021 | Pistons | 103 | Celtics | 108 |
| January | 9, 2021 | Cavaliers | 98 | Pistons | 95 |
| January | 10, 2021 | Rockets | 144 | Pistons | 130 |
| January | 12, 2021 | Pistons | 105 | Knicks | 110 |
| January | 13, 2021 | Heat | 117 | Pistons | 108 |
| January | 14, 2021 | Hornets | 82 | Pistons | 101 |
| January | 15, 2021 | Pistons | 108 | Clippers | 102 |
| January | 16, 2021 | Pistons | 99 | Hornets | 126 |
| January | 17, 2021 | Raptors | 87 | Pistons | 120 |
| January | 18, 2021 | Pistons | 103 | Cavaliers | 96 |
| January | 20, 2021 | Grizzlies | 96 | Pistons | 113 |
| January | 26, 2021 | Pistons | 111 | Cavaliers | 103 |
| January | 27, 2021 | Jazz | 120 | Pistons | 127 |
| February | 5, 2021 | 76ers | 116 | Pistons | 104 |
| February | 7, 2021 | Pistons | 114 | Warriors | 123 |
| February | 9, 2021 | Bulls | 105 | Pistons | 110 |
| February | 10, 2021 | Suns | 103 | Pistons | 120 |
| February | 12, 2021 | Pistons | 87 | Knicks | 125 |
| February | 14, 2021 | Pistons | 106 | 76ers | 111 |
| February | 15, 2021 | Pistons | 115 | Celtics | 107 |
| February | 18, 2021 | Hornets | 103 | Pistons | 119 |
| February | 19, 2021 | Pistons | 114 | Grizzlies | 110 |
| February | 21, 2021 | Cavaliers | 112 | Pistons | 116 |
| February | 23, 2021 | Celtics | 119 | Pistons | 129 |
| February | 24, 2021 | Pistons | 111 | Spurs | 116 |
| February | 25, 2021 | Nuggets | 125 | Pistons | 110 |
| February | 26, 2021 | Pistons | 98 | Knicks | 103 |
| February | 27, 2021 | Bulls | 117 | Pistons | 120 |
| March | 4, 2021 | Lakers | 90 | Pistons | 127 |
| March | 10, 2021 | Grizzlies | 103 | Pistons | 122 |
| March | 12, 2021 | Pistons | 107 | Nuggets | 103 |
| March | 18, 2021 | Pistons | 107 | Hornets | 110 |
| March | 19, 2021 | Celtics | 92 | Pistons | 114 |
| March | 23, 2021 | Heat | 134 | Pistons | 112 |
| March | 25, 2021 | Pistons | 120 | Rockets | 111 |
| March | 26, 2021 | Pistons | 103 | Heat | 112 |
| March | 27, 2021 | Warriors | 107 | Pistons | 112 |
| March | 28, 2021 | Pistons | 98 | Bulls | 107 |
| March | 30, 2021 | Pistons | 102 | Bulls | 110 |
| April | 1, 2021 | Knicks | 107 | Pistons | 119 |
| April | 10, 2021 | Grizzlies | 99 | Pistons | 109 |
| April | 15, 2021 | Knicks | 119 | Pistons | 122 |
| April | 16, 2021 | Celtics | 126 | Pistons | 133 |
| April | 18, 2021 | Clippers | 102 | Pistons | 105 |
| April | 20, 2021 | Sonics | 125 | Pistons | 126 |
| Post | 1, 2021 | Pistons | 103 | Celtics | 111 |
| Post | 2, 2021 | Pistons | 111 | Celtics | 106 |
| Post | 3, 2021 | Celtics | 111 | Pistons | 113 |
| Post | 4, 2021 | Celtics | 132 | Pistons | 101 |
| Post | 5, 2021 | Pistons | 100 | Celtics | 116 |
| Post | 6, 2021 | Celtics | 120 | Pistons | 117 |
| Post | 7, 2021 | Pistons | | Celtics | |