| month | day | visitor | score | home | score |
|---|
| November | 2, 2022 | Pistons | | Lakers | |
| November | 3, 2022 | Pistons | | Raptors | |
| November | 4, 2022 | Pistons | | Raptors | |
| November | 6, 2022 | Pistons | | Suns | |
| November | 7, 2022 | Pistons | | Celtics | |
| November | 10, 2022 | Pistons | | Bulls | |
| November | 11, 2022 | Bulls | | Pistons | |
| November | 12, 2022 | Pistons | | Grizzlies | |
| November | 15, 2022 | Pistons | | 76ers | |
| November | 19, 2022 | Pistons | | Timberwolves | |
| November | 20, 2022 | Knicks | | Pistons | |
| November | 22, 2022 | Pistons | | Jazz | |
| November | 23, 2022 | Pistons | | Heat | |
| November | 24, 2022 | Pistons | | Heat | |
| November | 26, 2022 | Raptors | | Pistons | |
| November | 28, 2022 | Hornets | | Pistons | |
| November | 29, 2022 | Cavaliers | | Pistons | |
| November | 30, 2022 | Spurs | | Pistons | |
| December | 1, 2022 | Raptors | | Pistons | |
| December | 6, 2022 | 76ers | | Pistons | |
| December | 7, 2022 | Heat | | Pistons | |
| December | 8, 2022 | Pistons | | 76ers | |
| December | 9, 2022 | Raptors | | Pistons | |
| December | 10, 2022 | 76ers | | Pistons | |
| December | 11, 2022 | Cavaliers | | Pistons | |
| December | 14, 2022 | Pistons | | Hornets | |
| December | 21, 2022 | Pistons | | Grizzlies | |
| December | 22, 2022 | Timberwolves | | Pistons | |
| December | 23, 2022 | Pistons | | Knicks | |
| December | 25, 2022 | Bulls | | Pistons | |
| December | 27, 2022 | Pistons | | Bulls | |
| December | 31, 2022 | Pistons | | Sonics | |
| January | 2, 2023 | Pistons | | Grizzlies | |
| January | 3, 2023 | Pistons | | Heat | |
| January | 4, 2023 | Pistons | | Cavaliers | |
| January | 5, 2023 | Grizzlies | | Pistons | |
| January | 7, 2023 | Pistons | | Raptors | |
| January | 8, 2023 | Pistons | | Celtics | |
| January | 9, 2023 | Cavaliers | | Pistons | |
| January | 10, 2023 | Rockets | | Pistons | |
| January | 12, 2023 | Pistons | | Knicks | |
| January | 13, 2023 | Heat | | Pistons | |
| January | 14, 2023 | Hornets | | Pistons | |
| January | 15, 2023 | Pistons | | Clippers | |
| January | 16, 2023 | Pistons | | Hornets | |
| January | 17, 2023 | Raptors | | Pistons | |
| January | 18, 2023 | Pistons | | Cavaliers | |
| January | 20, 2023 | Grizzlies | | Pistons | |
| January | 26, 2023 | Pistons | | Cavaliers | |
| January | 27, 2023 | Jazz | | Pistons | |
| February | 5, 2023 | 76ers | | Pistons | |
| February | 7, 2023 | Pistons | | Warriors | |
| February | 9, 2023 | Bulls | | Pistons | |
| February | 10, 2023 | Suns | | Pistons | |
| February | 12, 2023 | Pistons | | Knicks | |
| February | 14, 2023 | Pistons | | 76ers | |
| February | 15, 2023 | Pistons | | Celtics | |
| February | 18, 2023 | Hornets | | Pistons | |
| February | 19, 2023 | Pistons | | Grizzlies | |
| February | 21, 2023 | Cavaliers | | Pistons | |
| February | 23, 2023 | Celtics | | Pistons | |
| February | 24, 2023 | Pistons | | Spurs | |
| February | 25, 2023 | Nuggets | | Pistons | |
| February | 26, 2023 | Pistons | | Knicks | |
| February | 27, 2023 | Bulls | | Pistons | |
| March | 4, 2023 | Lakers | | Pistons | |
| March | 10, 2023 | Grizzlies | | Pistons | |
| March | 12, 2023 | Pistons | | Nuggets | |
| March | 18, 2023 | Pistons | | Hornets | |
| March | 19, 2023 | Celtics | | Pistons | |
| March | 23, 2023 | Heat | | Pistons | |
| March | 25, 2023 | Pistons | | Rockets | |
| March | 26, 2023 | Pistons | | Heat | |
| March | 27, 2023 | Warriors | | Pistons | |
| March | 28, 2023 | Pistons | | Bulls | |
| March | 30, 2023 | Pistons | | Bulls | |
| April | 1, 2023 | Knicks | | Pistons | |
| April | 10, 2023 | Grizzlies | | Pistons | |
| April | 15, 2023 | Knicks | | Pistons | |
| April | 16, 2023 | Celtics | | Pistons | |
| April | 18, 2023 | Clippers | | Pistons | |
| April | 20, 2023 | Sonics | | Pistons | |