| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Pistons | 122 | Lakers | 99 |
| November | 4, 2020 | 76ers | 107 | Lakers | 89 |
| November | 8, 2020 | Heat | 117 | Lakers | 104 |
| November | 9, 2020 | Lakers | 114 | Warriors | 119 |
| November | 10, 2020 | Hornets | 104 | Lakers | 126 |
| November | 11, 2020 | Lakers | 117 | Nuggets | 94 |
| November | 12, 2020 | Clippers | 102 | Lakers | 107 |
| November | 13, 2020 | Lakers | 132 | Nuggets | 120 |
| November | 14, 2020 | Bulls | 110 | Lakers | 120 |
| November | 17, 2020 | Timberwolves | 100 | Lakers | 114 |
| November | 20, 2020 | Lakers | 104 | Jazz | 120 |
| November | 21, 2020 | Lakers | 116 | Rockets | 119 |
| November | 24, 2020 | Jazz | 103 | Lakers | 115 |
| November | 27, 2020 | Lakers | 111 | Raptors | 100 |
| November | 29, 2020 | Jazz | 109 | Lakers | 113 |
| December | 3, 2020 | Lakers | 108 | Timberwolves | 112 |
| December | 4, 2020 | Rockets | 122 | Lakers | 110 |
| December | 6, 2020 | Spurs | 109 | Lakers | 116 |
| December | 8, 2020 | Lakers | 104 | Grizzlies | 128 |
| December | 10, 2020 | Lakers | 115 | Warriors | 138 |
| December | 12, 2020 | Timberwolves | 127 | Lakers | 109 |
| December | 13, 2020 | Clippers | 116 | Lakers | 122 |
| December | 16, 2020 | Lakers | 104 | Suns | 94 |
| December | 17, 2020 | Lakers | 90 | Spurs | 125 |
| December | 21, 2020 | Suns | 105 | Lakers | 125 |
| December | 24, 2020 | Nuggets | 111 | Lakers | 123 |
| December | 27, 2020 | Rockets | 110 | Lakers | 131 |
| December | 28, 2020 | Lakers | 89 | Clippers | 115 |
| December | 31, 2020 | Lakers | 100 | Spurs | 101 |
| January | 3, 2021 | Nuggets | 110 | Lakers | 115 |
| January | 4, 2021 | Clippers | 107 | Lakers | 116 |
| January | 9, 2021 | Lakers | 111 | Spurs | 92 |
| January | 11, 2021 | Sonics | 118 | Lakers | 103 |
| January | 13, 2021 | Clippers | 121 | Lakers | 112 |
| January | 14, 2021 | Lakers | 115 | 76ers | 129 |
| January | 16, 2021 | Sonics | 125 | Lakers | 110 |
| January | 17, 2021 | Lakers | 103 | Sonics | 120 |
| January | 21, 2021 | Lakers | 119 | Nuggets | 116 |
| January | 25, 2021 | Knicks | 125 | Lakers | 119 |
| January | 28, 2021 | Timberwolves | 105 | Lakers | 106 |
| January | 29, 2021 | Warriors | 129 | Lakers | 121 |
| January | 30, 2021 | Lakers | 103 | Suns | 126 |
| February | 7, 2021 | Lakers | 117 | Hornets | 118 |
| February | 8, 2021 | Lakers | 92 | Sonics | 113 |
| February | 9, 2021 | Suns | 106 | Lakers | 97 |
| February | 11, 2021 | Lakers | 103 | Timberwolves | 119 |
| February | 12, 2021 | Warriors | 113 | Lakers | 110 |
| February | 13, 2021 | Clippers | 115 | Lakers | 104 |
| February | 16, 2021 | Spurs | 94 | Lakers | 117 |
| February | 17, 2021 | Lakers | 110 | Sonics | 118 |
| February | 18, 2021 | Celtics | 119 | Lakers | 105 |
| February | 19, 2021 | Lakers | 95 | Rockets | 116 |
| February | 22, 2021 | Sonics | 117 | Lakers | 115 |
| February | 23, 2021 | Cavaliers | 96 | Lakers | 117 |
| February | 27, 2021 | Lakers | 110 | Heat | 120 |
| February | 28, 2021 | Jazz | 102 | Lakers | 98 |
| March | 1, 2021 | Nuggets | 110 | Lakers | 112 |
| March | 3, 2021 | Lakers | 97 | Warriors | 115 |
| March | 4, 2021 | Lakers | 90 | Pistons | 127 |
| March | 6, 2021 | Lakers | 124 | Rockets | 115 |
| March | 8, 2021 | Lakers | 108 | Spurs | 118 |
| March | 10, 2021 | Lakers | 121 | Warriors | 126 |
| March | 11, 2021 | Lakers | 117 | Celtics | 119 |
| March | 13, 2021 | Lakers | 101 | Bulls | 119 |
| March | 15, 2021 | Lakers | 118 | Timberwolves | 115 |
| March | 17, 2021 | Raptors | 131 | Lakers | 93 |
| March | 21, 2021 | Suns | 109 | Lakers | 121 |
| March | 22, 2021 | Lakers | 111 | Timberwolves | 114 |
| March | 24, 2021 | Grizzlies | 90 | Lakers | 111 |
| March | 25, 2021 | Lakers | 118 | Cavaliers | 126 |
| March | 29, 2021 | Nuggets | 106 | Lakers | 122 |
| March | 30, 2021 | Lakers | 128 | Suns | 122 |
| March | 31, 2021 | Lakers | 99 | Suns | 113 |
| April | 1, 2021 | Jazz | 123 | Lakers | 109 |
| April | 5, 2021 | Lakers | 99 | Sonics | 134 |
| April | 7, 2021 | Rockets | 80 | Lakers | 116 |
| April | 8, 2021 | Lakers | 126 | Rockets | 108 |
| April | 11, 2021 | Warriors | 98 | Lakers | 103 |
| April | 13, 2021 | Lakers | 110 | Clippers | 128 |
| April | 14, 2021 | Lakers | 97 | Knicks | 129 |
| April | 15, 2021 | Lakers | 104 | Jazz | 120 |
| April | 20, 2021 | Spurs | 103 | Lakers | 109 |
| Post | 1, 2021 | Lakers | 106 | Jazz | 108 |
| Post | 2, 2021 | Lakers | 96 | Jazz | 119 |
| Post | 3, 2021 | Jazz | 120 | Lakers | 83 |
| Post | 4, 2021 | Jazz | 111 | Lakers | 109 |
| Post | 5, 2021 | Lakers | | Jazz | |
| Post | 6, 2021 | Jazz | | Lakers | |
| Post | 7, 2021 | Lakers | | Jazz | |