| month | day | visitor | score | home | score |
|---|
| November | 2, 2020 | Grizzlies | 93 | Heat | 122 |
| November | 3, 2020 | Grizzlies | 97 | 76ers | 123 |
| November | 5, 2020 | Cavaliers | 108 | Grizzlies | 120 |
| November | 7, 2020 | Grizzlies | 108 | Raptors | 97 |
| November | 12, 2020 | Pistons | 91 | Grizzlies | 108 |
| November | 14, 2020 | Suns | 85 | Grizzlies | 83 |
| November | 15, 2020 | Jazz | 94 | Grizzlies | 101 |
| November | 18, 2020 | Hornets | 102 | Grizzlies | 114 |
| November | 21, 2020 | Spurs | 97 | Grizzlies | 101 |
| November | 22, 2020 | Knicks | 117 | Grizzlies | 121 |
| November | 23, 2020 | Grizzlies | 104 | Cavaliers | 115 |
| November | 25, 2020 | Grizzlies | 101 | Bulls | 108 |
| November | 26, 2020 | Grizzlies | 104 | 76ers | 126 |
| December | 2, 2020 | Grizzlies | 103 | Hornets | 101 |
| December | 3, 2020 | Grizzlies | 100 | Heat | 115 |
| December | 5, 2020 | Celtics | 95 | Grizzlies | 83 |
| December | 6, 2020 | Sonics | 110 | Grizzlies | 97 |
| December | 7, 2020 | Knicks | 110 | Grizzlies | 106 |
| December | 8, 2020 | Lakers | 104 | Grizzlies | 128 |
| December | 11, 2020 | Nuggets | 93 | Grizzlies | 119 |
| December | 17, 2020 | Cavaliers | 93 | Grizzlies | 102 |
| December | 18, 2020 | Bulls | 94 | Grizzlies | 85 |
| December | 19, 2020 | Warriors | 126 | Grizzlies | 103 |
| December | 20, 2020 | Grizzlies | 122 | Rockets | 108 |
| December | 21, 2020 | Pistons | 90 | Grizzlies | 104 |
| December | 28, 2020 | Grizzlies | 88 | Hornets | 120 |
| December | 29, 2020 | Cavaliers | 109 | Grizzlies | 110 |
| December | 30, 2020 | Hornets | 100 | Grizzlies | 114 |
| December | 31, 2020 | Bulls | 86 | Grizzlies | 75 |
| January | 1, 2021 | Grizzlies | 98 | Nuggets | 108 |
| January | 2, 2021 | Pistons | 109 | Grizzlies | 90 |
| January | 4, 2021 | Grizzlies | 82 | Celtics | 91 |
| January | 5, 2021 | Grizzlies | 96 | Pistons | 125 |
| January | 10, 2021 | Grizzlies | 72 | Celtics | 93 |
| January | 12, 2021 | Grizzlies | 108 | Warriors | 123 |
| January | 16, 2021 | Celtics | 103 | Grizzlies | 85 |
| January | 17, 2021 | Grizzlies | 103 | Hornets | 106 |
| January | 18, 2021 | Grizzlies | 91 | Raptors | 105 |
| January | 20, 2021 | Grizzlies | 96 | Pistons | 113 |
| January | 22, 2021 | Grizzlies | 85 | Bulls | 117 |
| January | 24, 2021 | Grizzlies | 99 | Heat | 137 |
| February | 8, 2021 | Celtics | 112 | Grizzlies | 91 |
| February | 12, 2021 | Grizzlies | 96 | Spurs | 111 |
| February | 13, 2021 | Grizzlies | 109 | Knicks | 127 |
| February | 16, 2021 | Grizzlies | 89 | Knicks | 122 |
| February | 17, 2021 | Bulls | 78 | Grizzlies | 79 |
| February | 19, 2021 | Pistons | 114 | Grizzlies | 110 |
| February | 20, 2021 | Raptors | 99 | Grizzlies | 100 |
| February | 24, 2021 | Heat | 119 | Grizzlies | 101 |
| February | 25, 2021 | Raptors | 98 | Grizzlies | 82 |
| February | 27, 2021 | Clippers | 96 | Grizzlies | 83 |
| February | 28, 2021 | Bulls | 111 | Grizzlies | 83 |
| March | 1, 2021 | Grizzlies | 99 | Knicks | 116 |
| March | 2, 2021 | Grizzlies | 96 | Celtics | 98 |
| March | 5, 2021 | Cavaliers | 114 | Grizzlies | 80 |
| March | 6, 2021 | Grizzlies | 90 | Jazz | 115 |
| March | 8, 2021 | Grizzlies | 79 | Hornets | 113 |
| March | 10, 2021 | Grizzlies | 103 | Pistons | 122 |
| March | 11, 2021 | Knicks | 110 | Grizzlies | 108 |
| March | 12, 2021 | 76ers | 124 | Grizzlies | 107 |
| March | 13, 2021 | Grizzlies | 83 | Suns | 100 |
| March | 14, 2021 | Grizzlies | 79 | Cavaliers | 94 |
| March | 15, 2021 | Heat | 104 | Grizzlies | 81 |
| March | 17, 2021 | Grizzlies | 93 | Cavaliers | 97 |
| March | 19, 2021 | Grizzlies | 82 | Bulls | 99 |
| March | 21, 2021 | Raptors | 102 | Grizzlies | 82 |
| March | 22, 2021 | Grizzlies | 102 | 76ers | 127 |
| March | 23, 2021 | Grizzlies | 87 | Timberwolves | 79 |
| March | 24, 2021 | Grizzlies | 90 | Lakers | 111 |
| March | 25, 2021 | Hornets | 93 | Grizzlies | 102 |
| March | 27, 2021 | Grizzlies | 102 | Raptors | 104 |
| March | 28, 2021 | Rockets | 104 | Grizzlies | 95 |
| March | 29, 2021 | Timberwolves | 75 | Grizzlies | 74 |
| March | 30, 2021 | Grizzlies | 97 | Clippers | 102 |
| April | 2, 2021 | Raptors | 106 | Grizzlies | 78 |
| April | 4, 2021 | 76ers | 113 | Grizzlies | 102 |
| April | 6, 2021 | Grizzlies | 105 | Sonics | 118 |
| April | 10, 2021 | Grizzlies | 99 | Pistons | 109 |
| April | 11, 2021 | Grizzlies | 100 | Knicks | 110 |
| April | 14, 2021 | 76ers | 103 | Grizzlies | 84 |
| April | 16, 2021 | Heat | 108 | Grizzlies | 98 |
| April | 20, 2021 | Grizzlies | 86 | Bulls | 93 |