| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Cavaliers | 99 | Celtics | 112 |
| November | 4, 2020 | Bulls | 110 | Cavaliers | 104 |
| November | 5, 2020 | Cavaliers | 108 | Grizzlies | 120 |
| November | 9, 2020 | Hornets | 117 | Cavaliers | 97 |
| November | 13, 2020 | Cavaliers | 114 | Knicks | 117 |
| November | 15, 2020 | Raptors | 108 | Cavaliers | 106 |
| November | 17, 2020 | Raptors | 96 | Cavaliers | 105 |
| November | 22, 2020 | Cavaliers | 90 | Sonics | 117 |
| November | 23, 2020 | Grizzlies | 104 | Cavaliers | 115 |
| November | 25, 2020 | Cavaliers | 93 | 76ers | 119 |
| November | 28, 2020 | Celtics | 134 | Cavaliers | 107 |
| November | 29, 2020 | Cavaliers | 98 | Pistons | 107 |
| November | 30, 2020 | Cavaliers | 100 | Jazz | 101 |
| December | 1, 2020 | Cavaliers | 111 | Heat | 135 |
| December | 2, 2020 | Cavaliers | 123 | Raptors | 131 |
| December | 4, 2020 | Heat | 123 | Cavaliers | 111 |
| December | 6, 2020 | Jazz | 116 | Cavaliers | 118 |
| December | 7, 2020 | Cavaliers | 109 | Raptors | 113 |
| December | 8, 2020 | Bulls | 117 | Cavaliers | 104 |
| December | 9, 2020 | Heat | 104 | Cavaliers | 107 |
| December | 11, 2020 | Cavaliers | 106 | Pistons | 91 |
| December | 12, 2020 | Cavaliers | 95 | Bulls | 101 |
| December | 16, 2020 | Celtics | 99 | Cavaliers | 113 |
| December | 17, 2020 | Cavaliers | 93 | Grizzlies | 102 |
| December | 18, 2020 | Hornets | 112 | Cavaliers | 132 |
| December | 22, 2020 | Cavaliers | 106 | 76ers | 107 |
| December | 23, 2020 | Bulls | 116 | Cavaliers | 90 |
| December | 26, 2020 | Bulls | 106 | Cavaliers | 101 |
| December | 27, 2020 | Cavaliers | 107 | Heat | 122 |
| December | 29, 2020 | Cavaliers | 109 | Grizzlies | 110 |
| December | 31, 2020 | 76ers | 99 | Cavaliers | 110 |
| January | 3, 2021 | Hornets | 110 | Cavaliers | 103 |
| January | 4, 2021 | Pistons | 95 | Cavaliers | 108 |
| January | 5, 2021 | Cavaliers | 102 | Bulls | 97 |
| January | 6, 2021 | Hornets | 105 | Cavaliers | 110 |
| January | 8, 2021 | 76ers | 102 | Cavaliers | 121 |
| January | 9, 2021 | Cavaliers | 98 | Pistons | 95 |
| January | 11, 2021 | Warriors | 123 | Cavaliers | 102 |
| January | 14, 2021 | Cavaliers | 107 | Nuggets | 97 |
| January | 17, 2021 | Clippers | 101 | Cavaliers | 103 |
| January | 18, 2021 | Pistons | 103 | Cavaliers | 96 |
| January | 19, 2021 | Cavaliers | 90 | Celtics | 98 |
| January | 22, 2021 | Cavaliers | 104 | Heat | 133 |
| January | 24, 2021 | Suns | 90 | Cavaliers | 75 |
| January | 25, 2021 | Cavaliers | 108 | Spurs | 96 |
| January | 26, 2021 | Pistons | 111 | Cavaliers | 103 |
| January | 29, 2021 | Cavaliers | 79 | Hornets | 112 |
| February | 7, 2021 | Knicks | 101 | Cavaliers | 146 |
| February | 8, 2021 | Nuggets | 89 | Cavaliers | 94 |
| February | 9, 2021 | Knicks | 103 | Cavaliers | 106 |
| February | 10, 2021 | Cavaliers | 94 | Raptors | 120 |
| February | 20, 2021 | 76ers | 94 | Cavaliers | 107 |
| February | 21, 2021 | Cavaliers | 112 | Pistons | 116 |
| February | 22, 2021 | Cavaliers | 107 | Knicks | 99 |
| February | 23, 2021 | Cavaliers | 96 | Lakers | 117 |
| February | 27, 2021 | Cavaliers | 101 | 76ers | 99 |
| February | 28, 2021 | Cavaliers | 107 | Warriors | 111 |
| March | 1, 2021 | Heat | 121 | Cavaliers | 117 |
| March | 3, 2021 | Timberwolves | 87 | Cavaliers | 102 |
| March | 5, 2021 | Cavaliers | 114 | Grizzlies | 80 |
| March | 7, 2021 | Raptors | 96 | Cavaliers | 111 |
| March | 9, 2021 | Rockets | 92 | Cavaliers | 108 |
| March | 10, 2021 | Cavaliers | 101 | Hornets | 99 |
| March | 11, 2021 | Cavaliers | 100 | Timberwolves | 88 |
| March | 12, 2021 | Knicks | 112 | Cavaliers | 109 |
| March | 14, 2021 | Grizzlies | 79 | Cavaliers | 94 |
| March | 16, 2021 | Sonics | 105 | Cavaliers | 119 |
| March | 17, 2021 | Grizzlies | 93 | Cavaliers | 97 |
| March | 20, 2021 | Cavaliers | 110 | Suns | 106 |
| March | 21, 2021 | Cavaliers | 100 | Heat | 118 |
| March | 25, 2021 | Lakers | 118 | Cavaliers | 126 |
| March | 26, 2021 | Knicks | 93 | Cavaliers | 120 |
| March | 29, 2021 | Cavaliers | 75 | Celtics | 100 |
| March | 30, 2021 | Cavaliers | 111 | Rockets | 95 |
| March | 31, 2021 | Cavaliers | 103 | 76ers | 108 |
| April | 3, 2021 | Cavaliers | 111 | Knicks | 119 |
| April | 6, 2021 | Cavaliers | 95 | Raptors | 104 |
| April | 10, 2021 | Cavaliers | 104 | Celtics | 102 |
| April | 14, 2021 | Cavaliers | 96 | Clippers | 95 |
| April | 17, 2021 | Celtics | 98 | Cavaliers | 85 |
| April | 18, 2021 | Spurs | 72 | Cavaliers | 103 |
| April | 19, 2021 | Bulls | 97 | Cavaliers | 94 |
| Post | 1, 2021 | Cavaliers | 92 | Heat | 124 |
| Post | 2, 2021 | Cavaliers | 109 | Heat | 112 |
| Post | 3, 2021 | Heat | 125 | Cavaliers | 106 |
| Post | 4, 2021 | Heat | 117 | Cavaliers | 96 |
| Post | 5, 2021 | Cavaliers | | Heat | |
| Post | 6, 2021 | Heat | | Cavaliers | |
| Post | 7, 2021 | Cavaliers | | Heat | |