| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Nuggets | 108 | Wolves | 105 |
| November | 6, 2021 | Grizzlies | 93 | Wolves | 108 |
| November | 8, 2021 | Wolves | 115 | Clippers | 119 |
| November | 10, 2021 | Spurs | 108 | Wolves | 132 |
| November | 12, 2021 | Kings | 103 | Wolves | 105 |
| November | 13, 2021 | Nuggets | 119 | Wolves | 97 |
| November | 14, 2021 | Lakers | 80 | Wolves | 89 |
| November | 16, 2021 | Wolves | 105 | Rockets | 109 |
| November | 19, 2021 | Bulls | 101 | Wolves | 126 |
| November | 21, 2021 | Wolves | 122 | Raptors | 96 |
| November | 22, 2021 | Wolves | 96 | Nets | 94 |
| November | 23, 2021 | Rockets | 137 | Wolves | 136 |
| November | 25, 2021 | Wolves | 106 | Kings | 113 |
| November | 27, 2021 | Mavericks | 126 | Wolves | 103 |
| November | 28, 2021 | Suns | 86 | Wolves | 109 |
| November | 30, 2021 | Wolves | 107 | Sonics | 109 |
| December | 4, 2021 | Warriors | 87 | Wolves | 115 |
| December | 6, 2021 | Wolves | 113 | Warriors | 110 |
| December | 8, 2021 | Wolves | 83 | Spurs | 107 |
| December | 9, 2021 | Wolves | 96 | Grizzlies | 92 |
| December | 15, 2021 | Clippers | 118 | Wolves | 123 |
| December | 16, 2021 | Wolves | 108 | Pelicans | 139 |
| December | 19, 2021 | Bucks | 93 | Wolves | 114 |
| December | 20, 2021 | Blazers | 122 | Wolves | 120 |
| December | 23, 2021 | Raptors | 125 | Wolves | 115 |
| January | 4, 2022 | Wolves | 91 | Celtics | 116 |
| January | 8, 2022 | 76ers | 91 | Wolves | 68 |
| January | 13, 2022 | Mavericks | 98 | Wolves | 81 |
| January | 14, 2022 | Spurs | 92 | Wolves | 78 |
| January | 18, 2022 | Sonics | 108 | Wolves | 69 |
| January | 19, 2022 | Wolves | 76 | Blazers | 115 |
| January | 20, 2022 | Wolves | 65 | Jazz | 95 |
| January | 21, 2022 | Wolves | 60 | Blazers | 107 |
| January | 23, 2022 | Wolves | 83 | 76ers | 84 |
| January | 24, 2022 | Suns | 93 | Wolves | 104 |
| January | 25, 2022 | Hawks | 85 | Wolves | 77 |
| January | 27, 2022 | Wolves | 78 | Bucks | 88 |
| January | 28, 2022 | Wolves | 85 | Jazz | 100 |
| January | 29, 2022 | Wolves | 91 | Bulls | 107 |
| January | 30, 2022 | Celtics | 98 | Wolves | 92 |
| January | 31, 2022 | Jazz | 78 | Wolves | 85 |
| February | 2, 2022 | Mavericks | | Wolves | |
| February | 11, 2022 | Wolves | | Jazz | |
| February | 18, 2022 | Wolves | | Knicks | |
| February | 22, 2022 | Wolves | | Nuggets | |
| February | 23, 2022 | Wolves | | Mavericks | |
| February | 24, 2022 | Wolves | | Spurs | |
| February | 26, 2022 | Rockets | | Wolves | |
| February | 27, 2022 | Wolves | | Warriors | |
| February | 28, 2022 | Wolves | | Suns | |
| March | 2, 2022 | Wolves | | Lakers | |
| March | 3, 2022 | Wolves | | Nuggets | |
| March | 10, 2022 | Wolves | | Mavericks | |
| March | 14, 2022 | Wolves | | Rockets | |
| March | 15, 2022 | Kings | | Wolves | |
| March | 17, 2022 | Suns | | Wolves | |
| March | 20, 2022 | Wolves | | Mavericks | |
| March | 24, 2022 | Nuggets | | Wolves | |
| March | 25, 2022 | Wolves | | Hawks | |
| March | 26, 2022 | Pacers | | Wolves | |
| March | 27, 2022 | Wolves | | Lakers | |
| March | 29, 2022 | Jazz | | Wolves | |
| March | 31, 2022 | Wolves | | Rockets | |
| April | 1, 2022 | Blazers | | Wolves | |
| April | 3, 2022 | Spurs | | Wolves | |
| April | 4, 2022 | Wolves | | Nuggets | |
| April | 5, 2022 | Heat | | Wolves | |
| April | 6, 2022 | Jazz | | Wolves | |
| April | 7, 2022 | Rockets | | Wolves | |
| April | 12, 2022 | Wolves | | Clippers | |
| April | 13, 2022 | Wolves | | Spurs | |
| April | 14, 2022 | Wolves | | Kings | |
| April | 15, 2022 | Wolves | | Heat | |
| April | 16, 2022 | Clippers | | Wolves | |
| April | 17, 2022 | Knicks | | Wolves | |
| April | 18, 2022 | Wolves | | Pacers | |
| April | 19, 2022 | Pelicans | | Wolves | |
| April | 20, 2022 | Warriors | | Wolves | |
| April | 21, 2022 | Lakers | | Wolves | |
| April | 22, 2022 | Wolves | | Suns | |
| April | 24, 2022 | Wolves | | Sonics | |
| April | 26, 2022 | Nets | | Wolves | |