| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Sonics | 80 | Kings | 74 |
| November | 5, 2021 | Sonics | 85 | Bucks | 126 |
| November | 7, 2021 | Kings | 85 | Sonics | 97 |
| November | 8, 2021 | Sonics | 113 | Raptors | 117 |
| November | 9, 2021 | Kings | 85 | Sonics | 92 |
| November | 10, 2021 | Jazz | 112 | Sonics | 99 |
| November | 11, 2021 | Sonics | 106 | Rockets | 124 |
| November | 12, 2021 | Sonics | 109 | Pelicans | 126 |
| November | 14, 2021 | Sonics | 90 | Warriors | 111 |
| November | 17, 2021 | Sonics | 94 | Clippers | 118 |
| November | 18, 2021 | Sonics | 76 | Nuggets | 123 |
| November | 21, 2021 | Sonics | 103 | Warriors | 82 |
| November | 25, 2021 | Sonics | 86 | Lakers | 101 |
| November | 30, 2021 | Wolves | 107 | Sonics | 109 |
| December | 2, 2021 | Sonics | 105 | Jazz | 101 |
| December | 5, 2021 | Warriors | 100 | Sonics | 123 |
| December | 6, 2021 | Sonics | 96 | Knicks | 111 |
| December | 7, 2021 | Blazers | 111 | Sonics | 102 |
| December | 8, 2021 | Bucks | 89 | Sonics | 98 |
| December | 11, 2021 | Sonics | 97 | Blazers | 98 |
| December | 13, 2021 | Jazz | 81 | Sonics | 99 |
| December | 14, 2021 | Blazers | 91 | Sonics | 89 |
| December | 16, 2021 | Heat | 107 | Sonics | 105 |
| December | 19, 2021 | Rockets | 80 | Sonics | 86 |
| December | 20, 2021 | Warriors | 86 | Sonics | 106 |
| December | 21, 2021 | Sonics | 102 | Lakers | 81 |
| December | 25, 2021 | Blazers | 89 | Sonics | 85 |
| December | 26, 2021 | Sonics | 104 | Bulls | 86 |
| December | 27, 2021 | Warriors | 88 | Sonics | 83 |
| December | 31, 2021 | Sonics | 93 | Suns | 111 |
| January | 1, 2022 | Sonics | 89 | Kings | 79 |
| January | 2, 2022 | Sonics | 61 | Blazers | 107 |
| January | 6, 2022 | Sonics | 120 | Nuggets | 116 |
| January | 7, 2022 | Spurs | 99 | Sonics | 98 |
| January | 8, 2022 | Sonics | 107 | Spurs | 113 |
| January | 9, 2022 | Nuggets | 110 | Sonics | 103 |
| January | 12, 2022 | Sonics | 106 | Warriors | 99 |
| January | 13, 2022 | Sonics | 70 | Rockets | 86 |
| January | 15, 2022 | Sonics | 102 | Hawks | 81 |
| January | 18, 2022 | Sonics | 108 | Wolves | 69 |
| January | 19, 2022 | Grizzlies | 85 | Sonics | 87 |
| January | 23, 2022 | Sonics | 91 | Nets | 76 |
| January | 25, 2022 | Mavericks | 99 | Sonics | 107 |
| January | 27, 2022 | Celtics | 117 | Sonics | 96 |
| January | 30, 2022 | Hawks | 88 | Sonics | 95 |
| January | 31, 2022 | 76ers | 74 | Sonics | 107 |
| February | 1, 2022 | Sonics | | Lakers | |
| February | 8, 2022 | Sonics | | Jazz | |
| February | 10, 2022 | Sonics | | Warriors | |
| February | 11, 2022 | Sonics | | Blazers | |
| February | 13, 2022 | Sonics | | Pacers | |
| February | 21, 2022 | Sonics | | Clippers | |
| March | 2, 2022 | Sonics | | Clippers | |
| March | 3, 2022 | Spurs | | Sonics | |
| March | 5, 2022 | Rockets | | Sonics | |
| March | 6, 2022 | Raptors | | Sonics | |
| March | 8, 2022 | Sonics | | Heat | |
| March | 11, 2022 | Sonics | | Spurs | |
| March | 12, 2022 | Sonics | | Kings | |
| March | 17, 2022 | Pelicans | | Sonics | |
| March | 19, 2022 | Sonics | | Suns | |
| March | 20, 2022 | Sonics | | Grizzlies | |
| March | 22, 2022 | Clippers | | Sonics | |
| March | 23, 2022 | Lakers | | Sonics | |
| March | 25, 2022 | Kings | | Sonics | |
| March | 27, 2022 | Sonics | | Mavericks | |
| March | 28, 2022 | Suns | | Sonics | |
| March | 30, 2022 | Sonics | | 76ers | |
| April | 2, 2022 | Clippers | | Sonics | |
| April | 3, 2022 | Nuggets | | Sonics | |
| April | 4, 2022 | Pacers | | Sonics | |
| April | 5, 2022 | Nets | | Sonics | |
| April | 6, 2022 | Sonics | | Celtics | |
| April | 9, 2022 | Mavericks | | Sonics | |
| April | 10, 2022 | Suns | | Sonics | |
| April | 16, 2022 | Lakers | | Sonics | |
| April | 17, 2022 | Sonics | | Mavericks | |
| April | 18, 2022 | Bulls | | Sonics | |
| April | 20, 2022 | Knicks | | Sonics | |
| April | 22, 2022 | Lakers | | Sonics | |
| April | 24, 2022 | Wolves | | Sonics | |
| April | 25, 2022 | Clippers | | Sonics | |