| month | day | visitor | score | home | score |
|---|
| November | 9, 2021 | Rockets | 110 | Warriors | 94 |
| November | 11, 2021 | Sonics | 106 | Rockets | 124 |
| November | 12, 2021 | Rockets | 111 | Heat | 105 |
| November | 14, 2021 | Rockets | 129 | Suns | 72 |
| November | 15, 2021 | Rockets | 114 | Spurs | 100 |
| November | 16, 2021 | Wolves | 105 | Rockets | 109 |
| November | 18, 2021 | Rockets | 123 | Celtics | 105 |
| November | 20, 2021 | Rockets | 120 | Nuggets | 142 |
| November | 23, 2021 | Rockets | 137 | Wolves | 136 |
| November | 24, 2021 | Mavericks | 110 | Rockets | 99 |
| November | 26, 2021 | Rockets | 113 | Blazers | 114 |
| November | 27, 2021 | Raptors | 104 | Rockets | 116 |
| November | 29, 2021 | Rockets | 105 | Warriors | 100 |
| November | 30, 2021 | Jazz | 105 | Rockets | 106 |
| December | 1, 2021 | Rockets | 103 | Nuggets | 109 |
| December | 3, 2021 | Rockets | 117 | Lakers | 99 |
| December | 4, 2021 | Rockets | 116 | 76ers | 89 |
| December | 10, 2021 | Warriors | 109 | Rockets | 119 |
| December | 12, 2021 | Clippers | 113 | Rockets | 116 |
| December | 15, 2021 | Kings | 83 | Rockets | 81 |
| December | 17, 2021 | Spurs | 110 | Rockets | 125 |
| December | 19, 2021 | Rockets | 80 | Sonics | 86 |
| December | 21, 2021 | Kings | 82 | Rockets | 108 |
| December | 22, 2021 | Pacers | 106 | Rockets | 125 |
| December | 25, 2021 | Rockets | 108 | Suns | 116 |
| December | 26, 2021 | Suns | 119 | Rockets | 123 |
| December | 27, 2021 | Rockets | 97 | Jazz | 115 |
| December | 30, 2021 | Bulls | 105 | Rockets | 92 |
| December | 31, 2021 | Mavericks | 92 | Rockets | 102 |
| January | 1, 2022 | Clippers | 102 | Rockets | 95 |
| January | 2, 2022 | Rockets | 79 | Lakers | 98 |
| January | 3, 2022 | Nuggets | 109 | Rockets | 99 |
| January | 4, 2022 | Rockets | 99 | Suns | 101 |
| January | 6, 2022 | Hawks | 95 | Rockets | 89 |
| January | 8, 2022 | Suns | 109 | Rockets | 107 |
| January | 10, 2022 | Pelicans | 105 | Rockets | 100 |
| January | 12, 2022 | Heat | 93 | Rockets | 97 |
| January | 13, 2022 | Sonics | 70 | Rockets | 86 |
| January | 14, 2022 | Nuggets | 101 | Rockets | 98 |
| January | 15, 2022 | Mavericks | 98 | Rockets | 95 |
| January | 18, 2022 | Lakers | 92 | Rockets | 99 |
| January | 20, 2022 | Rockets | 99 | Pelicans | 97 |
| January | 22, 2022 | Rockets | 83 | Mavericks | 95 |
| January | 24, 2022 | Rockets | 78 | Kings | 87 |
| January | 25, 2022 | 76ers | 73 | Rockets | 99 |
| January | 26, 2022 | Rockets | 93 | Grizzlies | 95 |
| January | 29, 2022 | Rockets | 83 | Kings | 85 |
| February | 1, 2022 | Rockets | | Raptors | |
| February | 2, 2022 | Rockets | | Jazz | |
| February | 8, 2022 | Blazers | | Rockets | |
| February | 14, 2022 | Rockets | | Knicks | |
| February | 15, 2022 | Spurs | | Rockets | |
| February | 16, 2022 | Jazz | | Rockets | |
| February | 19, 2022 | Rockets | | Mavericks | |
| February | 20, 2022 | Lakers | | Rockets | |
| February | 26, 2022 | Rockets | | Wolves | |
| February | 27, 2022 | Jazz | | Rockets | |
| March | 3, 2022 | Rockets | | Bucks | |
| March | 4, 2022 | Rockets | | Hawks | |
| March | 5, 2022 | Rockets | | Sonics | |
| March | 6, 2022 | Rockets | | Spurs | |
| March | 8, 2022 | Grizzlies | | Rockets | |
| March | 9, 2022 | Rockets | | Blazers | |
| March | 10, 2022 | Nets | | Rockets | |
| March | 12, 2022 | Blazers | | Rockets | |
| March | 13, 2022 | Rockets | | Mavericks | |
| March | 14, 2022 | Wolves | | Rockets | |
| March | 16, 2022 | Suns | | Rockets | |
| March | 20, 2022 | Nuggets | | Rockets | |
| March | 22, 2022 | Warriors | | Rockets | |
| March | 25, 2022 | Knicks | | Rockets | |
| March | 27, 2022 | Rockets | | Bulls | |
| March | 28, 2022 | Rockets | | Nets | |
| March | 30, 2022 | Rockets | | Clippers | |
| March | 31, 2022 | Wolves | | Rockets | |
| April | 1, 2022 | Rockets | | Spurs | |
| April | 3, 2022 | Bucks | | Rockets | |
| April | 7, 2022 | Rockets | | Wolves | |
| April | 8, 2022 | Rockets | | Jazz | |
| April | 17, 2022 | Rockets | | Clippers | |
| April | 23, 2022 | Rockets | | Pacers | |
| April | 26, 2022 | Celtics | | Rockets | |