| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Pelicans | 125 | Heat | 108 |
| November | 7, 2021 | Warriors | 101 | Pelicans | 136 |
| November | 9, 2021 | Heat | 114 | Pelicans | 129 |
| November | 12, 2021 | Sonics | 109 | Pelicans | 126 |
| November | 13, 2021 | Knicks | 126 | Pelicans | 125 |
| November | 17, 2021 | Pelicans | 125 | Suns | 102 |
| November | 20, 2021 | Blazers | 98 | Pelicans | 131 |
| November | 23, 2021 | Pelicans | 118 | Grizzlies | 110 |
| November | 25, 2021 | Clippers | 115 | Pelicans | 126 |
| November | 26, 2021 | Pelicans | 113 | Knicks | 118 |
| November | 27, 2021 | Grizzlies | 118 | Pelicans | 130 |
| December | 1, 2021 | Pelicans | 114 | Lakers | 115 |
| December | 3, 2021 | Pelicans | 116 | Heat | 101 |
| December | 6, 2021 | Bucks | 100 | Pelicans | 128 |
| December | 7, 2021 | Bulls | 113 | Pelicans | 125 |
| December | 8, 2021 | Celtics | 130 | Pelicans | 139 |
| December | 11, 2021 | Pelicans | 141 | Clippers | 110 |
| December | 12, 2021 | Kings | 96 | Pelicans | 125 |
| December | 14, 2021 | Pelicans | 131 | Bulls | 97 |
| December | 16, 2021 | Wolves | 108 | Pelicans | 139 |
| December | 17, 2021 | Hawks | 104 | Pelicans | 140 |
| December | 18, 2021 | Pelicans | 121 | 76ers | 116 |
| December | 21, 2021 | Spurs | 102 | Pelicans | 119 |
| December | 23, 2021 | 76ers | 100 | Pelicans | 123 |
| December | 24, 2021 | Pelicans | 157 | Celtics | 129 |
| December | 26, 2021 | Pelicans | 139 | Blazers | 115 |
| December | 30, 2021 | Pacers | 117 | Pelicans | 128 |
| January | 1, 2022 | Pelicans | 147 | Bucks | 106 |
| January | 3, 2022 | Pacers | 112 | Pelicans | 129 |
| January | 5, 2022 | Pelicans | 115 | Celtics | 113 |
| January | 10, 2022 | Pelicans | 105 | Rockets | 100 |
| January | 11, 2022 | Pacers | 109 | Pelicans | 127 |
| January | 16, 2022 | Nets | 97 | Pelicans | 116 |
| January | 17, 2022 | Pelicans | 130 | Hawks | 104 |
| January | 19, 2022 | Suns | 104 | Pelicans | 125 |
| January | 20, 2022 | Rockets | 99 | Pelicans | 97 |
| January | 26, 2022 | Pelicans | 90 | Bulls | 92 |
| February | 2, 2022 | Pelicans | | Raptors | |
| February | 9, 2022 | Pelicans | | Kings | |
| February | 11, 2022 | Pelicans | | Spurs | |
| February | 12, 2022 | Mavericks | | Pelicans | |
| February | 13, 2022 | Celtics | | Pelicans | |
| February | 14, 2022 | Pelicans | | 76ers | |
| February | 18, 2022 | Pelicans | | Nuggets | |
| February | 22, 2022 | Pelicans | | Mavericks | |
| February | 24, 2022 | Celtics | | Pelicans | |
| February | 25, 2022 | Knicks | | Pelicans | |
| February | 26, 2022 | Heat | | Pelicans | |
| February | 27, 2022 | Pelicans | | Pacers | |
| February | 28, 2022 | Lakers | | Pelicans | |
| March | 5, 2022 | Pelicans | | Raptors | |
| March | 6, 2022 | Pelicans | | Nets | |
| March | 8, 2022 | Pelicans | | Bulls | |
| March | 12, 2022 | 76ers | | Pelicans | |
| March | 13, 2022 | Pelicans | | Grizzlies | |
| March | 15, 2022 | Nuggets | | Pelicans | |
| March | 16, 2022 | Pelicans | | Nets | |
| March | 17, 2022 | Pelicans | | Sonics | |
| March | 19, 2022 | Knicks | | Pelicans | |
| March | 21, 2022 | Nets | | Pelicans | |
| March | 24, 2022 | Pelicans | | Grizzlies | |
| March | 26, 2022 | Pelicans | | Celtics | |
| March | 27, 2022 | Pelicans | | 76ers | |
| March | 28, 2022 | Pelicans | | Heat | |
| March | 31, 2022 | Pelicans | | Knicks | |
| April | 1, 2022 | Pelicans | | Pacers | |
| April | 2, 2022 | Nets | | Pelicans | |
| April | 4, 2022 | Hawks | | Pelicans | |
| April | 5, 2022 | Raptors | | Pelicans | |
| April | 8, 2022 | Heat | | Pelicans | |
| April | 9, 2022 | Pelicans | | Hawks | |
| April | 10, 2022 | Nets | | Pelicans | |
| April | 11, 2022 | Knicks | | Pelicans | |
| April | 12, 2022 | Pelicans | | Warriors | |
| April | 13, 2022 | 76ers | | Pelicans | |
| April | 14, 2022 | Pelicans | | Jazz | |
| April | 19, 2022 | Pelicans | | Wolves | |
| April | 20, 2022 | Raptors | | Pelicans | |
| April | 22, 2022 | Pelicans | | Bucks | |
| April | 23, 2022 | Jazz | | Pelicans | |
| April | 25, 2022 | Pelicans | | Bucks | |
| April | 26, 2022 | Hawks | | Pelicans | |