| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Bucks | 96 | Pacers | 119 |
| November | 4, 2021 | Pacers | 104 | Clippers | 123 |
| November | 9, 2021 | Bucks | 111 | Pacers | 101 |
| November | 11, 2021 | Kings | 120 | Pacers | 105 |
| November | 12, 2021 | Pacers | 103 | Bucks | 112 |
| November | 13, 2021 | Raptors | 90 | Pacers | 118 |
| November | 16, 2021 | Raptors | 120 | Pacers | 130 |
| November | 17, 2021 | Pacers | 115 | Blazers | 120 |
| November | 19, 2021 | Raptors | 127 | Pacers | 104 |
| November | 22, 2021 | 76ers | 91 | Pacers | 129 |
| November | 25, 2021 | Mavericks | 107 | Pacers | 118 |
| November | 28, 2021 | Hawks | 111 | Pacers | 117 |
| November | 29, 2021 | Pacers | 118 | 76ers | 100 |
| December | 1, 2021 | Clippers | 114 | Pacers | 133 |
| December | 2, 2021 | Hawks | 140 | Pacers | 135 |
| December | 9, 2021 | Pacers | 106 | Knicks | 113 |
| December | 11, 2021 | Knicks | 110 | Pacers | 102 |
| December | 12, 2021 | Grizzlies | 130 | Pacers | 116 |
| December | 13, 2021 | Warriors | 107 | Pacers | 101 |
| December | 16, 2021 | Hawks | 121 | Pacers | 106 |
| December | 18, 2021 | Bucks | 113 | Pacers | 129 |
| December | 22, 2021 | Pacers | 106 | Rockets | 125 |
| December | 23, 2021 | Pacers | 115 | Spurs | 122 |
| December | 24, 2021 | Bulls | 111 | Pacers | 108 |
| December | 27, 2021 | Pacers | 104 | Nuggets | 119 |
| December | 30, 2021 | Pacers | 117 | Pelicans | 128 |
| January | 3, 2022 | Pacers | 112 | Pelicans | 129 |
| January | 6, 2022 | Pacers | 119 | Suns | 115 |
| January | 11, 2022 | Pacers | 109 | Pelicans | 127 |
| January | 13, 2022 | Grizzlies | 107 | Pacers | 104 |
| January | 15, 2022 | Pacers | 113 | Nets | 116 |
| January | 17, 2022 | Knicks | 109 | Pacers | 104 |
| January | 18, 2022 | Bucks | 129 | Pacers | 125 |
| January | 20, 2022 | Nets | 111 | Pacers | 117 |
| January | 21, 2022 | Pacers | 105 | Hawks | 110 |
| January | 22, 2022 | Pacers | 125 | Raptors | 130 |
| January | 23, 2022 | Pacers | 103 | Grizzlies | 102 |
| January | 26, 2022 | Blazers | 120 | Pacers | 105 |
| January | 27, 2022 | Nets | 100 | Pacers | 113 |
| January | 28, 2022 | Celtics | 99 | Pacers | 109 |
| February | 1, 2022 | Pacers | | Bulls | |
| February | 2, 2022 | Pacers | | Bucks | |
| February | 4, 2022 | Pacers | | Knicks | |
| February | 9, 2022 | Heat | | Pacers | |
| February | 13, 2022 | Sonics | | Pacers | |
| February | 15, 2022 | Heat | | Pacers | |
| February | 18, 2022 | Bulls | | Pacers | |
| February | 21, 2022 | Grizzlies | | Pacers | |
| February | 22, 2022 | Bulls | | Pacers | |
| February | 23, 2022 | Pacers | | Heat | |
| February | 25, 2022 | Pacers | | Jazz | |
| February | 27, 2022 | Pelicans | | Pacers | |
| February | 28, 2022 | Pacers | | Warriors | |
| March | 1, 2022 | Pacers | | Raptors | |
| March | 2, 2022 | Jazz | | Pacers | |
| March | 7, 2022 | Suns | | Pacers | |
| March | 10, 2022 | Pacers | | Raptors | |
| March | 13, 2022 | Pacers | | Nets | |
| March | 15, 2022 | Pacers | | Hawks | |
| March | 16, 2022 | Pacers | | Celtics | |
| March | 18, 2022 | Pacers | | Kings | |
| March | 23, 2022 | Pacers | | Bucks | |
| March | 24, 2022 | Pacers | | Raptors | |
| March | 25, 2022 | Celtics | | Pacers | |
| March | 26, 2022 | Pacers | | Wolves | |
| March | 28, 2022 | Pacers | | Bulls | |
| March | 29, 2022 | 76ers | | Pacers | |
| March | 31, 2022 | Pacers | | Lakers | |
| April | 1, 2022 | Pelicans | | Pacers | |
| April | 2, 2022 | Pacers | | Bucks | |
| April | 4, 2022 | Pacers | | Sonics | |
| April | 5, 2022 | Pacers | | Mavericks | |
| April | 7, 2022 | Pacers | | Grizzlies | |
| April | 8, 2022 | Nuggets | | Pacers | |
| April | 10, 2022 | Lakers | | Pacers | |
| April | 11, 2022 | Pacers | | Heat | |
| April | 12, 2022 | Pacers | | 76ers | |
| April | 16, 2022 | Pacers | | Celtics | |
| April | 18, 2022 | Wolves | | Pacers | |
| April | 19, 2022 | Pacers | | Bulls | |
| April | 23, 2022 | Rockets | | Pacers | |
| April | 24, 2022 | Spurs | | Pacers | |