| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Raptors | 105 | Mavericks | 120 |
| November | 5, 2021 | Mavericks | 126 | Warriors | 83 |
| November | 8, 2021 | Jazz | 77 | Mavericks | 112 |
| November | 11, 2021 | Mavericks | 116 | Bucks | 118 |
| November | 12, 2021 | Mavericks | 117 | Blazers | 96 |
| November | 14, 2021 | Mavericks | 108 | Kings | 76 |
| November | 15, 2021 | Hawks | 125 | Mavericks | 123 |
| November | 18, 2021 | Spurs | 100 | Mavericks | 119 |
| November | 20, 2021 | Mavericks | 101 | Kings | 98 |
| November | 24, 2021 | Mavericks | 110 | Rockets | 99 |
| November | 25, 2021 | Mavericks | 107 | Pacers | 118 |
| November | 26, 2021 | Mavericks | 110 | Nuggets | 109 |
| November | 27, 2021 | Mavericks | 126 | Wolves | 103 |
| November | 28, 2021 | Mavericks | 115 | Celtics | 105 |
| December | 3, 2021 | Warriors | 67 | Mavericks | 106 |
| December | 5, 2021 | Nuggets | 104 | Mavericks | 100 |
| December | 10, 2021 | Mavericks | 102 | Suns | 107 |
| December | 14, 2021 | Mavericks | 110 | Hawks | 107 |
| December | 16, 2021 | Mavericks | 121 | Jazz | 99 |
| December | 18, 2021 | Clippers | 132 | Mavericks | 126 |
| December | 19, 2021 | Mavericks | 95 | Clippers | 123 |
| December | 20, 2021 | Spurs | 102 | Mavericks | 105 |
| December | 21, 2021 | Mavericks | 89 | Nets | 81 |
| December | 22, 2021 | Mavericks | 116 | Spurs | 114 |
| December | 27, 2021 | Blazers | 87 | Mavericks | 117 |
| December | 28, 2021 | Blazers | 121 | Mavericks | 117 |
| December | 30, 2021 | Mavericks | 113 | Clippers | 116 |
| December | 31, 2021 | Mavericks | 92 | Rockets | 102 |
| January | 1, 2022 | Mavericks | 124 | Suns | 106 |
| January | 4, 2022 | Bucks | 123 | Mavericks | 121 |
| January | 5, 2022 | Bulls | 100 | Mavericks | 124 |
| January | 7, 2022 | Mavericks | 113 | 76ers | 106 |
| January | 9, 2022 | Mavericks | 102 | Jazz | 124 |
| January | 13, 2022 | Mavericks | 98 | Wolves | 81 |
| January | 14, 2022 | Lakers | 108 | Mavericks | 113 |
| January | 15, 2022 | Mavericks | 98 | Rockets | 95 |
| January | 16, 2022 | Jazz | 113 | Mavericks | 117 |
| January | 17, 2022 | Spurs | 98 | Mavericks | 113 |
| January | 20, 2022 | Mavericks | 106 | Spurs | 99 |
| January | 22, 2022 | Rockets | 83 | Mavericks | 95 |
| January | 24, 2022 | Jazz | 95 | Mavericks | 115 |
| January | 25, 2022 | Mavericks | 99 | Sonics | 107 |
| January | 28, 2022 | Suns | 89 | Mavericks | 105 |
| January | 29, 2022 | Nuggets | 111 | Mavericks | 136 |
| January | 31, 2022 | Mavericks | 119 | Nuggets | 97 |
| February | 2, 2022 | Mavericks | | Wolves | |
| February | 4, 2022 | Kings | | Mavericks | |
| February | 8, 2022 | Heat | | Mavericks | |
| February | 12, 2022 | Mavericks | | Pelicans | |
| February | 13, 2022 | Mavericks | | Nuggets | |
| February | 14, 2022 | Mavericks | | Bulls | |
| February | 15, 2022 | Mavericks | | Raptors | |
| February | 17, 2022 | Mavericks | | Grizzlies | |
| February | 19, 2022 | Rockets | | Mavericks | |
| February | 20, 2022 | 76ers | | Mavericks | |
| February | 22, 2022 | Pelicans | | Mavericks | |
| February | 23, 2022 | Wolves | | Mavericks | |
| February | 24, 2022 | Mavericks | | Warriors | |
| February | 27, 2022 | Mavericks | | Suns | |
| March | 1, 2022 | Clippers | | Mavericks | |
| March | 4, 2022 | Warriors | | Mavericks | |
| March | 6, 2022 | Mavericks | | Lakers | |
| March | 8, 2022 | Knicks | | Mavericks | |
| March | 10, 2022 | Wolves | | Mavericks | |
| March | 13, 2022 | Rockets | | Mavericks | |
| March | 14, 2022 | Kings | | Mavericks | |
| March | 15, 2022 | Mavericks | | Spurs | |
| March | 20, 2022 | Wolves | | Mavericks | |
| March | 27, 2022 | Sonics | | Mavericks | |
| April | 2, 2022 | Lakers | | Mavericks | |
| April | 3, 2022 | Mavericks | | Knicks | |
| April | 5, 2022 | Pacers | | Mavericks | |
| April | 8, 2022 | Suns | | Mavericks | |
| April | 9, 2022 | Mavericks | | Sonics | |
| April | 10, 2022 | Mavericks | | Blazers | |
| April | 12, 2022 | Grizzlies | | Mavericks | |
| April | 15, 2022 | Suns | | Mavericks | |
| April | 17, 2022 | Sonics | | Mavericks | |
| April | 21, 2022 | Mavericks | | Heat | |
| April | 23, 2022 | Mavericks | | Lakers | |
| April | 24, 2022 | Celtics | | Mavericks | |
| April | 25, 2022 | Nets | | Mavericks | |