| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Warriors | 106 | Lakers | 118 |
| November | 4, 2021 | Warriors | 90 | Lakers | 116 |
| November | 5, 2021 | Clippers | 104 | Lakers | 106 |
| November | 6, 2021 | Lakers | 98 | Hawks | 126 |
| November | 7, 2021 | Lakers | 96 | Jazz | 120 |
| November | 8, 2021 | Bulls | 81 | Lakers | 123 |
| November | 10, 2021 | Lakers | 107 | Clippers | 112 |
| November | 12, 2021 | Lakers | 120 | Nuggets | 123 |
| November | 13, 2021 | Lakers | 89 | Spurs | 94 |
| November | 14, 2021 | Lakers | 80 | Wolves | 89 |
| November | 15, 2021 | Kings | 85 | Lakers | 80 |
| November | 20, 2021 | Lakers | 96 | Bucks | 115 |
| November | 22, 2021 | Suns | 105 | Lakers | 92 |
| November | 23, 2021 | Lakers | 93 | Heat | 105 |
| November | 25, 2021 | Sonics | 86 | Lakers | 101 |
| November | 26, 2021 | Lakers | 98 | Warriors | 104 |
| December | 1, 2021 | Pelicans | 114 | Lakers | 115 |
| December | 3, 2021 | Rockets | 117 | Lakers | 99 |
| December | 5, 2021 | Lakers | 81 | Kings | 92 |
| December | 7, 2021 | Clippers | 124 | Lakers | 97 |
| December | 8, 2021 | Kings | 107 | Lakers | 105 |
| December | 12, 2021 | Lakers | 107 | Raptors | 118 |
| December | 14, 2021 | Lakers | 107 | Clippers | 129 |
| December | 15, 2021 | Grizzlies | 109 | Lakers | 122 |
| December | 19, 2021 | Jazz | 90 | Lakers | 119 |
| December | 21, 2021 | Sonics | 102 | Lakers | 81 |
| December | 23, 2021 | Knicks | 125 | Lakers | 113 |
| December | 24, 2021 | Clippers | 108 | Lakers | 120 |
| December | 25, 2021 | Lakers | 96 | Clippers | 113 |
| December | 29, 2021 | Lakers | 107 | Blazers | 91 |
| December | 31, 2021 | Lakers | 105 | Celtics | 126 |
| January | 2, 2022 | Rockets | 79 | Lakers | 98 |
| January | 5, 2022 | Lakers | 102 | Spurs | 115 |
| January | 6, 2022 | Heat | 118 | Lakers | 111 |
| January | 7, 2022 | Kings | 91 | Lakers | 110 |
| January | 8, 2022 | Lakers | 86 | Nets | 99 |
| January | 14, 2022 | Lakers | 108 | Mavericks | 113 |
| January | 15, 2022 | Lakers | 110 | Blazers | 100 |
| January | 16, 2022 | Raptors | 107 | Lakers | 103 |
| January | 18, 2022 | Lakers | 92 | Rockets | 99 |
| January | 20, 2022 | Lakers | 109 | Nuggets | 111 |
| January | 21, 2022 | Lakers | 94 | Kings | 89 |
| January | 23, 2022 | Lakers | 86 | Jazz | 100 |
| January | 31, 2022 | Lakers | 106 | Knicks | 122 |
| February | 1, 2022 | Sonics | | Lakers | |
| February | 8, 2022 | Nuggets | | Lakers | |
| February | 9, 2022 | 76ers | | Lakers | |
| February | 14, 2022 | Blazers | | Lakers | |
| February | 15, 2022 | Lakers | | Warriors | |
| February | 18, 2022 | Jazz | | Lakers | |
| February | 20, 2022 | Lakers | | Rockets | |
| February | 21, 2022 | Nets | | Lakers | |
| February | 22, 2022 | Lakers | | Suns | |
| February | 25, 2022 | Celtics | | Lakers | |
| February | 28, 2022 | Lakers | | Pelicans | |
| March | 1, 2022 | Lakers | | 76ers | |
| March | 2, 2022 | Wolves | | Lakers | |
| March | 3, 2022 | Lakers | | Grizzlies | |
| March | 6, 2022 | Mavericks | | Lakers | |
| March | 9, 2022 | Spurs | | Lakers | |
| March | 10, 2022 | Warriors | | Lakers | |
| March | 12, 2022 | Spurs | | Lakers | |
| March | 16, 2022 | Bucks | | Lakers | |
| March | 18, 2022 | Suns | | Lakers | |
| March | 19, 2022 | Nuggets | | Lakers | |
| March | 23, 2022 | Lakers | | Sonics | |
| March | 26, 2022 | Lakers | | Kings | |
| March | 27, 2022 | Wolves | | Lakers | |
| March | 28, 2022 | Lakers | | Blazers | |
| March | 31, 2022 | Pacers | | Lakers | |
| April | 2, 2022 | Lakers | | Mavericks | |
| April | 8, 2022 | Lakers | | Bulls | |
| April | 10, 2022 | Lakers | | Pacers | |
| April | 11, 2022 | Lakers | | Warriors | |
| April | 15, 2022 | Blazers | | Lakers | |
| April | 16, 2022 | Lakers | | Sonics | |
| April | 17, 2022 | Hawks | | Lakers | |
| April | 18, 2022 | Lakers | | Suns | |
| April | 21, 2022 | Lakers | | Wolves | |
| April | 22, 2022 | Lakers | | Sonics | |
| April | 23, 2022 | Mavericks | | Lakers | |
| April | 25, 2022 | Blazers | | Lakers | |