| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Celtics | 103 | Knicks | 124 |
| November | 3, 2021 | Knicks | 90 | 76ers | 101 |
| November | 4, 2021 | Knicks | 120 | Spurs | 103 |
| November | 6, 2021 | Knicks | 102 | Nets | 73 |
| November | 7, 2021 | 76ers | 88 | Knicks | 113 |
| November | 13, 2021 | Knicks | 126 | Pelicans | 125 |
| November | 15, 2021 | Bulls | 112 | Knicks | 122 |
| November | 17, 2021 | Raptors | 95 | Knicks | 125 |
| November | 19, 2021 | Knicks | 120 | Bucks | 113 |
| November | 21, 2021 | Blazers | 91 | Knicks | 122 |
| November | 24, 2021 | Grizzlies | 79 | Knicks | 107 |
| November | 26, 2021 | Pelicans | 113 | Knicks | 118 |
| November | 27, 2021 | Heat | 98 | Knicks | 100 |
| November | 28, 2021 | Knicks | 106 | Heat | 89 |
| November | 29, 2021 | Knicks | 99 | Nets | 82 |
| November | 30, 2021 | Knicks | 93 | Blazers | 101 |
| December | 2, 2021 | Knicks | 100 | Clippers | 131 |
| December | 4, 2021 | Knicks | 87 | Nets | 98 |
| December | 6, 2021 | Sonics | 96 | Knicks | 111 |
| December | 7, 2021 | Nets | 72 | Knicks | 92 |
| December | 9, 2021 | Pacers | 106 | Knicks | 113 |
| December | 10, 2021 | Heat | 101 | Knicks | 119 |
| December | 11, 2021 | Knicks | 110 | Pacers | 102 |
| December | 12, 2021 | 76ers | 112 | Knicks | 116 |
| December | 14, 2021 | Knicks | 107 | Raptors | 104 |
| December | 15, 2021 | Knicks | 101 | Bucks | 104 |
| December | 18, 2021 | Nets | 103 | Knicks | 92 |
| December | 19, 2021 | Knicks | 120 | Bulls | 113 |
| December | 23, 2021 | Knicks | 125 | Lakers | 113 |
| December | 25, 2021 | Jazz | 106 | Knicks | 129 |
| December | 26, 2021 | Raptors | 113 | Knicks | 120 |
| December | 28, 2021 | Knicks | 106 | Celtics | 126 |
| December | 30, 2021 | 76ers | 92 | Knicks | 107 |
| January | 4, 2022 | Knicks | 117 | Raptors | 113 |
| January | 5, 2022 | Knicks | 96 | Bucks | 122 |
| January | 8, 2022 | Knicks | 99 | Celtics | 104 |
| January | 9, 2022 | Knicks | 116 | Hawks | 107 |
| January | 10, 2022 | Knicks | 109 | Suns | 99 |
| January | 11, 2022 | Hawks | 94 | Knicks | 139 |
| January | 13, 2022 | Bucks | 119 | Knicks | 124 |
| January | 17, 2022 | Knicks | 109 | Pacers | 104 |
| January | 18, 2022 | Knicks | 123 | Nuggets | 115 |
| January | 24, 2022 | Grizzlies | 90 | Knicks | 102 |
| January | 26, 2022 | Heat | 96 | Knicks | 115 |
| January | 28, 2022 | Hawks | 105 | Knicks | 119 |
| January | 29, 2022 | Knicks | 97 | 76ers | 79 |
| January | 30, 2022 | Grizzlies | 88 | Knicks | 99 |
| January | 31, 2022 | Lakers | 106 | Knicks | 122 |
| February | 4, 2022 | Pacers | | Knicks | |
| February | 14, 2022 | Rockets | | Knicks | |
| February | 17, 2022 | Nuggets | | Knicks | |
| February | 18, 2022 | Wolves | | Knicks | |
| February | 19, 2022 | Knicks | | 76ers | |
| February | 22, 2022 | Knicks | | Warriors | |
| February | 25, 2022 | Knicks | | Pelicans | |
| February | 27, 2022 | Knicks | | Kings | |
| March | 2, 2022 | Spurs | | Knicks | |
| March | 4, 2022 | Celtics | | Knicks | |
| March | 5, 2022 | Warriors | | Knicks | |
| March | 7, 2022 | Clippers | | Knicks | |
| March | 8, 2022 | Knicks | | Mavericks | |
| March | 9, 2022 | Hawks | | Knicks | |
| March | 11, 2022 | Knicks | | Nets | |
| March | 17, 2022 | Celtics | | Knicks | |
| March | 18, 2022 | Celtics | | Knicks | |
| March | 19, 2022 | Knicks | | Pelicans | |
| March | 22, 2022 | Knicks | | Hawks | |
| March | 25, 2022 | Knicks | | Rockets | |
| March | 31, 2022 | Pelicans | | Knicks | |
| April | 1, 2022 | Knicks | | Bulls | |
| April | 3, 2022 | Mavericks | | Knicks | |
| April | 5, 2022 | Bulls | | Knicks | |
| April | 6, 2022 | Kings | | Knicks | |
| April | 7, 2022 | Heat | | Knicks | |
| April | 11, 2022 | Knicks | | Pelicans | |
| April | 14, 2022 | Suns | | Knicks | |
| April | 17, 2022 | Knicks | | Wolves | |
| April | 20, 2022 | Knicks | | Sonics | |
| April | 21, 2022 | Knicks | | Jazz | |
| April | 22, 2022 | Knicks | | Heat | |
| April | 23, 2022 | Knicks | | Grizzlies | |
| April | 26, 2022 | Knicks | | Grizzlies | |