| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Warriors | 117 | Clippers | 110 |
| November | 4, 2021 | Pacers | 104 | Clippers | 123 |
| November | 5, 2021 | Clippers | 104 | Lakers | 106 |
| November | 7, 2021 | Suns | 104 | Clippers | 117 |
| November | 8, 2021 | Wolves | 115 | Clippers | 119 |
| November | 10, 2021 | Lakers | 107 | Clippers | 112 |
| November | 11, 2021 | Jazz | 100 | Clippers | 109 |
| November | 15, 2021 | Warriors | 107 | Clippers | 126 |
| November | 17, 2021 | Sonics | 94 | Clippers | 118 |
| November | 21, 2021 | Nuggets | 95 | Clippers | 128 |
| November | 25, 2021 | Clippers | 115 | Pelicans | 126 |
| November | 30, 2021 | Clippers | 77 | Kings | 131 |
| December | 1, 2021 | Clippers | 114 | Pacers | 133 |
| December | 2, 2021 | Knicks | 100 | Clippers | 131 |
| December | 6, 2021 | Spurs | 108 | Clippers | 111 |
| December | 7, 2021 | Clippers | 124 | Lakers | 97 |
| December | 11, 2021 | Pelicans | 141 | Clippers | 110 |
| December | 12, 2021 | Clippers | 113 | Rockets | 116 |
| December | 14, 2021 | Lakers | 107 | Clippers | 129 |
| December | 15, 2021 | Clippers | 118 | Wolves | 123 |
| December | 18, 2021 | Clippers | 132 | Mavericks | 126 |
| December | 19, 2021 | Mavericks | 95 | Clippers | 123 |
| December | 20, 2021 | Nets | 99 | Clippers | 129 |
| December | 22, 2021 | Bulls | 88 | Clippers | 126 |
| December | 24, 2021 | Clippers | 108 | Lakers | 120 |
| December | 25, 2021 | Lakers | 96 | Clippers | 113 |
| December | 28, 2021 | Clippers | 99 | Raptors | 133 |
| December | 30, 2021 | Mavericks | 113 | Clippers | 116 |
| December | 31, 2021 | Clippers | 103 | Bulls | 119 |
| January | 1, 2022 | Clippers | 102 | Rockets | 95 |
| January | 5, 2022 | Kings | 89 | Clippers | 92 |
| January | 9, 2022 | Spurs | 94 | Clippers | 111 |
| January | 10, 2022 | Clippers | 106 | Blazers | 105 |
| January | 11, 2022 | Clippers | 125 | Spurs | 115 |
| January | 14, 2022 | Clippers | 120 | Warriors | 119 |
| January | 18, 2022 | Clippers | 100 | Warriors | 114 |
| January | 19, 2022 | Heat | 120 | Clippers | 113 |
| January | 21, 2022 | Clippers | 101 | Spurs | 104 |
| January | 24, 2022 | Clippers | 101 | Nets | 81 |
| January | 25, 2022 | Clippers | 121 | Warriors | 104 |
| January | 29, 2022 | Raptors | 97 | Clippers | 107 |
| February | 1, 2022 | Clippers | | Hawks | |
| February | 4, 2022 | Clippers | | Grizzlies | |
| February | 9, 2022 | Suns | | Clippers | |
| February | 10, 2022 | Clippers | | Heat | |
| February | 11, 2022 | Hawks | | Clippers | |
| February | 12, 2022 | 76ers | | Clippers | |
| February | 15, 2022 | Clippers | | Kings | |
| February | 16, 2022 | Clippers | | Kings | |
| February | 21, 2022 | Sonics | | Clippers | |
| February | 23, 2022 | Clippers | | 76ers | |
| February | 25, 2022 | Clippers | | Suns | |
| February | 26, 2022 | Clippers | | Celtics | |
| February | 27, 2022 | Clippers | | Nuggets | |
| March | 1, 2022 | Clippers | | Mavericks | |
| March | 2, 2022 | Sonics | | Clippers | |
| March | 3, 2022 | Kings | | Clippers | |
| March | 7, 2022 | Clippers | | Knicks | |
| March | 11, 2022 | Clippers | | Nuggets | |
| March | 13, 2022 | Kings | | Clippers | |
| March | 14, 2022 | Clippers | | Bucks | |
| March | 15, 2022 | Clippers | | Blazers | |
| March | 18, 2022 | Clippers | | Jazz | |
| March | 21, 2022 | Warriors | | Clippers | |
| March | 22, 2022 | Clippers | | Sonics | |
| March | 23, 2022 | Grizzlies | | Clippers | |
| March | 30, 2022 | Rockets | | Clippers | |
| March | 31, 2022 | Clippers | | Blazers | |
| April | 1, 2022 | Nuggets | | Clippers | |
| April | 2, 2022 | Clippers | | Sonics | |
| April | 7, 2022 | Celtics | | Clippers | |
| April | 9, 2022 | Blazers | | Clippers | |
| April | 11, 2022 | Clippers | | Jazz | |
| April | 12, 2022 | Wolves | | Clippers | |
| April | 13, 2022 | Bucks | | Clippers | |
| April | 16, 2022 | Clippers | | Wolves | |
| April | 17, 2022 | Rockets | | Clippers | |
| April | 19, 2022 | Blazers | | Clippers | |
| April | 20, 2022 | Jazz | | Clippers | |
| April | 21, 2022 | Clippers | | Suns | |
| April | 24, 2022 | Blazers | | Clippers | |
| April | 25, 2022 | Clippers | | Sonics | |