| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Nets | 82 | Bulls | 115 |
| November | 8, 2021 | Bulls | 81 | Lakers | 123 |
| November | 9, 2021 | Bulls | 110 | 76ers | 112 |
| November | 10, 2021 | Warriors | 103 | Bulls | 124 |
| November | 14, 2021 | 76ers | 123 | Bulls | 112 |
| November | 15, 2021 | Bulls | 112 | Knicks | 122 |
| November | 16, 2021 | Bulls | 116 | Bucks | 102 |
| November | 17, 2021 | Bulls | 111 | Hawks | 116 |
| November | 19, 2021 | Bulls | 101 | Wolves | 126 |
| November | 20, 2021 | Raptors | 119 | Bulls | 121 |
| November | 21, 2021 | Bulls | 108 | Grizzlies | 101 |
| November | 25, 2021 | Bulls | 108 | Celtics | 118 |
| November | 26, 2021 | Bucks | 119 | Bulls | 136 |
| December | 3, 2021 | Bulls | 116 | Suns | 112 |
| December | 6, 2021 | Bulls | 115 | Hawks | 128 |
| December | 7, 2021 | Bulls | 113 | Pelicans | 125 |
| December | 8, 2021 | Bulls | 115 | Hawks | 135 |
| December | 9, 2021 | Bulls | 109 | Raptors | 132 |
| December | 11, 2021 | Bulls | 102 | Grizzlies | 106 |
| December | 13, 2021 | Bulls | 74 | Kings | 104 |
| December | 14, 2021 | Pelicans | 131 | Bulls | 97 |
| December | 17, 2021 | Celtics | 101 | Bulls | 111 |
| December | 19, 2021 | Knicks | 120 | Bulls | 113 |
| December | 20, 2021 | Suns | 119 | Bulls | 124 |
| December | 21, 2021 | Bulls | 107 | Heat | 115 |
| December | 22, 2021 | Bulls | 88 | Clippers | 126 |
| December | 24, 2021 | Bulls | 111 | Pacers | 108 |
| December | 26, 2021 | Sonics | 104 | Bulls | 86 |
| December | 30, 2021 | Bulls | 105 | Rockets | 92 |
| December | 31, 2021 | Clippers | 103 | Bulls | 119 |
| January | 3, 2022 | Hawks | 90 | Bulls | 107 |
| January | 5, 2022 | Bulls | 100 | Mavericks | 124 |
| January | 7, 2022 | Bulls | 96 | Warriors | 107 |
| January | 9, 2022 | Heat | 97 | Bulls | 104 |
| January | 11, 2022 | Kings | 113 | Bulls | 94 |
| January | 12, 2022 | Bulls | 118 | Jazz | 106 |
| January | 16, 2022 | Bulls | 134 | Hawks | 127 |
| January | 21, 2022 | Jazz | 113 | Bulls | 121 |
| January | 22, 2022 | Hawks | 112 | Bulls | 130 |
| January | 25, 2022 | Spurs | 106 | Bulls | 120 |
| January | 26, 2022 | Pelicans | 90 | Bulls | 92 |
| January | 28, 2022 | Bulls | 94 | Grizzlies | 110 |
| January | 29, 2022 | Wolves | 91 | Bulls | 107 |
| January | 30, 2022 | 76ers | 90 | Bulls | 114 |
| February | 1, 2022 | Pacers | | Bulls | |
| February | 9, 2022 | Bulls | | Nuggets | |
| February | 11, 2022 | Bucks | | Bulls | |
| February | 12, 2022 | Bulls | | Raptors | |
| February | 14, 2022 | Mavericks | | Bulls | |
| February | 16, 2022 | Bulls | | Spurs | |
| February | 18, 2022 | Bulls | | Pacers | |
| February | 19, 2022 | Bulls | | Grizzlies | |
| February | 20, 2022 | Grizzlies | | Bulls | |
| February | 22, 2022 | Bulls | | Pacers | |
| February | 28, 2022 | Bulls | | Bucks | |
| March | 1, 2022 | Bulls | | Celtics | |
| March | 4, 2022 | Raptors | | Bulls | |
| March | 7, 2022 | Bulls | | Nets | |
| March | 8, 2022 | Pelicans | | Bulls | |
| March | 9, 2022 | Celtics | | Bulls | |
| March | 10, 2022 | Bulls | | Celtics | |
| March | 16, 2022 | Grizzlies | | Bulls | |
| March | 20, 2022 | Heat | | Bulls | |
| March | 21, 2022 | Bulls | | 76ers | |
| March | 22, 2022 | Bulls | | Blazers | |
| March | 23, 2022 | Nets | | Bulls | |
| March | 24, 2022 | Blazers | | Bulls | |
| March | 27, 2022 | Rockets | | Bulls | |
| March | 28, 2022 | Pacers | | Bulls | |
| March | 31, 2022 | Nuggets | | Bulls | |
| April | 1, 2022 | Knicks | | Bulls | |
| April | 4, 2022 | Bulls | | Heat | |
| April | 5, 2022 | Bulls | | Knicks | |
| April | 6, 2022 | Nets | | Bulls | |
| April | 8, 2022 | Lakers | | Bulls | |
| April | 9, 2022 | Bulls | | 76ers | |
| April | 15, 2022 | Raptors | | Bulls | |
| April | 18, 2022 | Bulls | | Sonics | |
| April | 19, 2022 | Pacers | | Bulls | |
| April | 21, 2022 | Bucks | | Bulls | |
| April | 24, 2022 | Bulls | | Raptors | |
| April | 26, 2022 | Bucks | | Bulls | |