| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Bucks | 96 | Pacers | 119 |
| November | 4, 2021 | 76ers | 110 | Bucks | 102 |
| November | 5, 2021 | Sonics | 85 | Bucks | 126 |
| November | 8, 2021 | Nets | 113 | Bucks | 110 |
| November | 9, 2021 | Bucks | 111 | Pacers | 101 |
| November | 11, 2021 | Mavericks | 116 | Bucks | 118 |
| November | 12, 2021 | Pacers | 103 | Bucks | 112 |
| November | 16, 2021 | Bulls | 116 | Bucks | 102 |
| November | 18, 2021 | Bucks | 114 | 76ers | 125 |
| November | 19, 2021 | Knicks | 120 | Bucks | 113 |
| November | 20, 2021 | Lakers | 96 | Bucks | 115 |
| November | 23, 2021 | Hawks | 134 | Bucks | 139 |
| November | 26, 2021 | Bucks | 119 | Bulls | 136 |
| November | 29, 2021 | Bucks | 111 | Celtics | 107 |
| November | 30, 2021 | Bucks | 114 | Hawks | 110 |
| December | 4, 2021 | Bucks | 91 | Blazers | 109 |
| December | 6, 2021 | Bucks | 100 | Pelicans | 128 |
| December | 7, 2021 | Bucks | 117 | Spurs | 123 |
| December | 8, 2021 | Bucks | 89 | Sonics | 98 |
| December | 15, 2021 | Knicks | 101 | Bucks | 104 |
| December | 16, 2021 | Bucks | 104 | Suns | 112 |
| December | 17, 2021 | 76ers | 100 | Bucks | 93 |
| December | 18, 2021 | Bucks | 113 | Pacers | 129 |
| December | 19, 2021 | Bucks | 93 | Wolves | 114 |
| December | 22, 2021 | Bucks | 96 | Raptors | 117 |
| December | 23, 2021 | Grizzlies | 106 | Bucks | 92 |
| December | 25, 2021 | Bucks | 112 | Hawks | 116 |
| December | 27, 2021 | Raptors | 134 | Bucks | 101 |
| December | 28, 2021 | Bucks | 89 | Nets | 103 |
| January | 1, 2022 | Pelicans | 147 | Bucks | 106 |
| January | 3, 2022 | Heat | 103 | Bucks | 115 |
| January | 4, 2022 | Bucks | 123 | Mavericks | 121 |
| January | 5, 2022 | Knicks | 96 | Bucks | 122 |
| January | 8, 2022 | Bucks | 105 | Kings | 111 |
| January | 11, 2022 | Blazers | 97 | Bucks | 142 |
| January | 12, 2022 | Raptors | 128 | Bucks | 120 |
| January | 13, 2022 | Bucks | 119 | Knicks | 124 |
| January | 14, 2022 | Bucks | 135 | 76ers | 105 |
| January | 18, 2022 | Bucks | 129 | Pacers | 125 |
| January | 21, 2022 | Bucks | 130 | Heat | 94 |
| January | 23, 2022 | Bucks | 119 | Hawks | 113 |
| January | 27, 2022 | Wolves | 78 | Bucks | 88 |
| January | 29, 2022 | Spurs | 113 | Bucks | 117 |
| January | 30, 2022 | Suns | 114 | Bucks | 103 |
| February | 1, 2022 | Grizzlies | | Bucks | |
| February | 2, 2022 | Pacers | | Bucks | |
| February | 8, 2022 | Nets | | Bucks | |
| February | 11, 2022 | Bucks | | Bulls | |
| February | 16, 2022 | Bucks | | Heat | |
| February | 18, 2022 | Bucks | | Grizzlies | |
| February | 19, 2022 | Hawks | | Bucks | |
| February | 20, 2022 | Heat | | Bucks | |
| February | 21, 2022 | Bucks | | Warriors | |
| February | 24, 2022 | Bucks | | Grizzlies | |
| February | 25, 2022 | Bucks | | Grizzlies | |
| February | 26, 2022 | Bucks | | Grizzlies | |
| February | 28, 2022 | Bulls | | Bucks | |
| March | 3, 2022 | Rockets | | Bucks | |
| March | 6, 2022 | Warriors | | Bucks | |
| March | 7, 2022 | Jazz | | Bucks | |
| March | 9, 2022 | Bucks | | Raptors | |
| March | 11, 2022 | Kings | | Bucks | |
| March | 12, 2022 | Bucks | | Celtics | |
| March | 14, 2022 | Clippers | | Bucks | |
| March | 16, 2022 | Bucks | | Lakers | |
| March | 17, 2022 | Nuggets | | Bucks | |
| March | 23, 2022 | Pacers | | Bucks | |
| March | 24, 2022 | Bucks | | Hawks | |
| March | 25, 2022 | Bucks | | Raptors | |
| March | 29, 2022 | Bucks | | Nuggets | |
| March | 30, 2022 | Celtics | | Bucks | |
| April | 2, 2022 | Pacers | | Bucks | |
| April | 3, 2022 | Bucks | | Rockets | |
| April | 9, 2022 | Bucks | | Jazz | |
| April | 13, 2022 | Bucks | | Clippers | |
| April | 15, 2022 | Celtics | | Bucks | |
| April | 19, 2022 | Nets | | Bucks | |
| April | 21, 2022 | Bucks | | Bulls | |
| April | 22, 2022 | Pelicans | | Bucks | |
| April | 23, 2022 | Raptors | | Bucks | |
| April | 25, 2022 | Pelicans | | Bucks | |
| April | 26, 2022 | Bucks | | Bulls | |