| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Blazers | 106 | Jazz | 109 |
| November | 4, 2021 | Nets | 77 | Blazers | 97 |
| November | 6, 2021 | Blazers | 94 | 76ers | 116 |
| November | 12, 2021 | Mavericks | 117 | Blazers | 96 |
| November | 13, 2021 | Blazers | 107 | Warriors | 111 |
| November | 16, 2021 | Kings | 98 | Blazers | 72 |
| November | 17, 2021 | Pacers | 115 | Blazers | 120 |
| November | 20, 2021 | Blazers | 98 | Pelicans | 131 |
| November | 21, 2021 | Blazers | 91 | Knicks | 122 |
| November | 24, 2021 | Blazers | 118 | Jazz | 121 |
| November | 26, 2021 | Rockets | 113 | Blazers | 114 |
| November | 30, 2021 | Knicks | 93 | Blazers | 101 |
| December | 1, 2021 | Blazers | 84 | Kings | 107 |
| December | 2, 2021 | Blazers | 85 | Nets | 82 |
| December | 3, 2021 | Jazz | 117 | Blazers | 122 |
| December | 4, 2021 | Bucks | 91 | Blazers | 109 |
| December | 7, 2021 | Blazers | 111 | Sonics | 102 |
| December | 10, 2021 | Raptors | 119 | Blazers | 118 |
| December | 11, 2021 | Sonics | 97 | Blazers | 98 |
| December | 14, 2021 | Blazers | 91 | Sonics | 89 |
| December | 16, 2021 | Nuggets | 98 | Blazers | 103 |
| December | 18, 2021 | Heat | 102 | Blazers | 122 |
| December | 20, 2021 | Blazers | 122 | Wolves | 120 |
| December | 22, 2021 | Jazz | 118 | Blazers | 110 |
| December | 24, 2021 | Blazers | 104 | Heat | 102 |
| December | 25, 2021 | Blazers | 89 | Sonics | 85 |
| December | 26, 2021 | Pelicans | 139 | Blazers | 115 |
| December | 27, 2021 | Blazers | 87 | Mavericks | 117 |
| December | 28, 2021 | Blazers | 121 | Mavericks | 117 |
| December | 29, 2021 | Lakers | 107 | Blazers | 91 |
| January | 1, 2022 | Blazers | 98 | Spurs | 95 |
| January | 2, 2022 | Sonics | 61 | Blazers | 107 |
| January | 4, 2022 | Warriors | 92 | Blazers | 119 |
| January | 6, 2022 | Kings | 83 | Blazers | 94 |
| January | 10, 2022 | Clippers | 106 | Blazers | 105 |
| January | 11, 2022 | Blazers | 97 | Bucks | 142 |
| January | 12, 2022 | Kings | 107 | Blazers | 110 |
| January | 15, 2022 | Lakers | 110 | Blazers | 100 |
| January | 16, 2022 | Blazers | 98 | Warriors | 118 |
| January | 17, 2022 | Suns | 94 | Blazers | 101 |
| January | 19, 2022 | Wolves | 76 | Blazers | 115 |
| January | 21, 2022 | Wolves | 60 | Blazers | 107 |
| January | 23, 2022 | Warriors | 102 | Blazers | 123 |
| January | 26, 2022 | Blazers | 120 | Pacers | 105 |
| January | 27, 2022 | Nuggets | 131 | Blazers | 114 |
| January | 28, 2022 | Blazers | 95 | Spurs | 102 |
| February | 4, 2022 | Blazers | | Nuggets | |
| February | 8, 2022 | Blazers | | Rockets | |
| February | 10, 2022 | 76ers | | Blazers | |
| February | 11, 2022 | Sonics | | Blazers | |
| February | 14, 2022 | Blazers | | Lakers | |
| February | 17, 2022 | Blazers | | Suns | |
| February | 20, 2022 | Blazers | | Kings | |
| February | 23, 2022 | Celtics | | Blazers | |
| March | 1, 2022 | Blazers | | Nuggets | |
| March | 6, 2022 | Blazers | | Kings | |
| March | 9, 2022 | Rockets | | Blazers | |
| March | 12, 2022 | Blazers | | Rockets | |
| March | 13, 2022 | Blazers | | Raptors | |
| March | 15, 2022 | Clippers | | Blazers | |
| March | 19, 2022 | Blazers | | Warriors | |
| March | 21, 2022 | Hawks | | Blazers | |
| March | 22, 2022 | Bulls | | Blazers | |
| March | 24, 2022 | Blazers | | Bulls | |
| March | 28, 2022 | Lakers | | Blazers | |
| March | 31, 2022 | Clippers | | Blazers | |
| April | 1, 2022 | Blazers | | Wolves | |
| April | 3, 2022 | Blazers | | Suns | |
| April | 5, 2022 | Suns | | Blazers | |
| April | 6, 2022 | Grizzlies | | Blazers | |
| April | 9, 2022 | Blazers | | Clippers | |
| April | 10, 2022 | Mavericks | | Blazers | |
| April | 11, 2022 | Spurs | | Blazers | |
| April | 13, 2022 | Blazers | | Grizzlies | |
| April | 14, 2022 | Blazers | | Celtics | |
| April | 15, 2022 | Blazers | | Lakers | |
| April | 19, 2022 | Blazers | | Clippers | |
| April | 21, 2022 | Warriors | | Blazers | |
| April | 22, 2022 | Spurs | | Blazers | |
| April | 23, 2022 | Blazers | | Hawks | |
| April | 24, 2022 | Blazers | | Clippers | |
| April | 25, 2022 | Blazers | | Lakers | |