| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Knicks | 90 | 76ers | 101 |
| November | 4, 2021 | 76ers | 110 | Bucks | 102 |
| November | 5, 2021 | 76ers | 89 | Celtics | 115 |
| November | 6, 2021 | Blazers | 94 | 76ers | 116 |
| November | 7, 2021 | 76ers | 88 | Knicks | 113 |
| November | 9, 2021 | Bulls | 110 | 76ers | 112 |
| November | 14, 2021 | 76ers | 123 | Bulls | 112 |
| November | 18, 2021 | Bucks | 114 | 76ers | 125 |
| November | 22, 2021 | 76ers | 91 | Pacers | 129 |
| November | 23, 2021 | Celtics | 108 | 76ers | 104 |
| November | 24, 2021 | 76ers | 91 | Nets | 117 |
| November | 27, 2021 | 76ers | 76 | Kings | 97 |
| November | 29, 2021 | Pacers | 118 | 76ers | 100 |
| December | 2, 2021 | Heat | 94 | 76ers | 101 |
| December | 3, 2021 | 76ers | 109 | Nuggets | 125 |
| December | 4, 2021 | Rockets | 116 | 76ers | 89 |
| December | 5, 2021 | 76ers | 103 | Heat | 129 |
| December | 7, 2021 | Warriors | 108 | 76ers | 114 |
| December | 12, 2021 | 76ers | 112 | Knicks | 116 |
| December | 13, 2021 | 76ers | 72 | Nets | 92 |
| December | 17, 2021 | 76ers | 100 | Bucks | 93 |
| December | 18, 2021 | Pelicans | 121 | 76ers | 116 |
| December | 20, 2021 | Hawks | 117 | 76ers | 122 |
| December | 21, 2021 | Raptors | 124 | 76ers | 96 |
| December | 23, 2021 | 76ers | 100 | Pelicans | 123 |
| December | 25, 2021 | Grizzlies | 86 | 76ers | 92 |
| December | 26, 2021 | 76ers | 89 | Celtics | 126 |
| December | 27, 2021 | 76ers | 107 | Suns | 114 |
| December | 28, 2021 | Heat | 95 | 76ers | 105 |
| December | 30, 2021 | 76ers | 92 | Knicks | 107 |
| January | 2, 2022 | Heat | 130 | 76ers | 111 |
| January | 4, 2022 | Grizzlies | 109 | 76ers | 86 |
| January | 6, 2022 | 76ers | 99 | Celtics | 120 |
| January | 7, 2022 | Mavericks | 113 | 76ers | 106 |
| January | 8, 2022 | 76ers | 91 | Wolves | 68 |
| January | 13, 2022 | 76ers | 77 | Nets | 92 |
| January | 14, 2022 | Bucks | 135 | 76ers | 105 |
| January | 15, 2022 | Kings | 84 | 76ers | 103 |
| January | 17, 2022 | Jazz | 97 | 76ers | 102 |
| January | 19, 2022 | 76ers | 96 | Warriors | 109 |
| January | 22, 2022 | Celtics | 111 | 76ers | 86 |
| January | 23, 2022 | Wolves | 83 | 76ers | 84 |
| January | 25, 2022 | 76ers | 73 | Rockets | 99 |
| January | 29, 2022 | Knicks | 97 | 76ers | 79 |
| January | 30, 2022 | 76ers | 90 | Bulls | 114 |
| January | 31, 2022 | 76ers | 74 | Sonics | 107 |
| February | 8, 2022 | 76ers | | Raptors | |
| February | 9, 2022 | 76ers | | Lakers | |
| February | 10, 2022 | 76ers | | Blazers | |
| February | 11, 2022 | Raptors | | 76ers | |
| February | 12, 2022 | 76ers | | Clippers | |
| February | 13, 2022 | 76ers | | Grizzlies | |
| February | 14, 2022 | Pelicans | | 76ers | |
| February | 15, 2022 | Nets | | 76ers | |
| February | 17, 2022 | 76ers | | Hawks | |
| February | 19, 2022 | Knicks | | 76ers | |
| February | 20, 2022 | 76ers | | Mavericks | |
| February | 23, 2022 | Clippers | | 76ers | |
| February | 26, 2022 | Nets | | 76ers | |
| February | 28, 2022 | 76ers | | Spurs | |
| March | 1, 2022 | Lakers | | 76ers | |
| March | 5, 2022 | 76ers | | Grizzlies | |
| March | 7, 2022 | 76ers | | Celtics | |
| March | 10, 2022 | Hawks | | 76ers | |
| March | 11, 2022 | 76ers | | Jazz | |
| March | 12, 2022 | 76ers | | Pelicans | |
| March | 14, 2022 | 76ers | | Hawks | |
| March | 16, 2022 | Raptors | | 76ers | |
| March | 21, 2022 | Bulls | | 76ers | |
| March | 27, 2022 | Pelicans | | 76ers | |
| March | 29, 2022 | 76ers | | Pacers | |
| March | 30, 2022 | Sonics | | 76ers | |
| March | 31, 2022 | 76ers | | Raptors | |
| April | 2, 2022 | 76ers | | Heat | |
| April | 6, 2022 | 76ers | | Heat | |
| April | 8, 2022 | Spurs | | 76ers | |
| April | 9, 2022 | Bulls | | 76ers | |
| April | 12, 2022 | Pacers | | 76ers | |
| April | 13, 2022 | 76ers | | Pelicans | |
| April | 16, 2022 | Nuggets | | 76ers | |
| April | 18, 2022 | Nets | | 76ers | |
| April | 19, 2022 | Suns | | 76ers | |