| month | day | visitor | score | home | score |
|---|
| November | 4, 2020 | Knicks | 93 | Spurs | 106 |
| November | 5, 2020 | Spurs | 110 | Heat | 105 |
| November | 10, 2020 | Spurs | 108 | Wolves | 113 |
| November | 13, 2020 | Lakers | 98 | Spurs | 121 |
| November | 15, 2020 | Rockets | 110 | Spurs | 128 |
| November | 18, 2020 | Spurs | 76 | Mavericks | 108 |
| November | 19, 2020 | Grizzlies | 91 | Spurs | 107 |
| November | 22, 2020 | Jazz | 115 | Spurs | 98 |
| November | 27, 2020 | Jazz | 97 | Spurs | 113 |
| November | 29, 2020 | Suns | 107 | Spurs | 114 |
| December | 5, 2020 | Jazz | 103 | Spurs | 111 |
| December | 6, 2020 | Spurs | 107 | Clippers | 111 |
| December | 7, 2020 | Bucks | 108 | Spurs | 106 |
| December | 8, 2020 | Wolves | 89 | Spurs | 92 |
| December | 10, 2020 | Nuggets | 103 | Spurs | 102 |
| December | 11, 2020 | Warriors | 114 | Spurs | 141 |
| December | 13, 2020 | Hawks | 107 | Spurs | 124 |
| December | 15, 2020 | Spurs | 94 | Celtics | 113 |
| December | 17, 2020 | Spurs | 99 | Rockets | 124 |
| December | 20, 2020 | Spurs | 101 | Mavericks | 103 |
| December | 21, 2020 | Spurs | 102 | Pelicans | 96 |
| December | 22, 2020 | Mavericks | 80 | Spurs | 95 |
| December | 23, 2020 | Pacers | 96 | Spurs | 122 |
| December | 31, 2020 | Kings | 88 | Spurs | 105 |
| January | 1, 2021 | Blazers | 97 | Spurs | 116 |
| January | 2, 2021 | Nets | 114 | Spurs | 97 |
| January | 3, 2021 | Spurs | 99 | Kings | 98 |
| January | 5, 2021 | Lakers | 59 | Spurs | 89 |
| January | 7, 2021 | Spurs | 130 | Sonics | 98 |
| January | 8, 2021 | Sonics | 104 | Spurs | 120 |
| January | 9, 2021 | Spurs | 113 | Clippers | 101 |
| January | 11, 2021 | Clippers | 96 | Spurs | 95 |
| January | 14, 2021 | Spurs | 77 | Wolves | 84 |
| January | 17, 2021 | Spurs | 87 | Mavericks | 109 |
| January | 20, 2021 | Mavericks | 90 | Spurs | 93 |
| January | 21, 2021 | Clippers | 104 | Spurs | 111 |
| January | 25, 2021 | Spurs | 102 | Bulls | 108 |
| January | 27, 2021 | Spurs | 103 | Jazz | 81 |
| January | 28, 2021 | Blazers | 122 | Spurs | 124 |
| January | 29, 2021 | Spurs | 97 | Bucks | 102 |
| February | 1, 2021 | Kings | | Spurs | |
| February | 2, 2021 | Spurs | | Nuggets | |
| February | 4, 2021 | Heat | | Spurs | |
| February | 9, 2021 | Spurs | | Jazz | |
| February | 11, 2021 | Pelicans | | Spurs | |
| February | 12, 2021 | Warriors | | Spurs | |
| February | 13, 2021 | Spurs | | Kings | |
| February | 15, 2021 | Spurs | | Rockets | |
| February | 16, 2021 | Bulls | | Spurs | |
| February | 21, 2021 | Spurs | | Nuggets | |
| February | 24, 2021 | Wolves | | Spurs | |
| February | 26, 2021 | Spurs | | Hawks | |
| February | 28, 2021 | 76ers | | Spurs | |
| March | 2, 2021 | Spurs | | Knicks | |
| March | 3, 2021 | Spurs | | Sonics | |
| March | 4, 2021 | Spurs | | Nuggets | |
| March | 6, 2021 | Rockets | | Spurs | |
| March | 8, 2021 | Spurs | | Suns | |
| March | 9, 2021 | Spurs | | Lakers | |
| March | 11, 2021 | Sonics | | Spurs | |
| March | 12, 2021 | Spurs | | Lakers | |
| March | 15, 2021 | Mavericks | | Spurs | |
| March | 21, 2021 | Celtics | | Spurs | |
| March | 23, 2021 | Spurs | | Warriors | |
| March | 27, 2021 | Spurs | | Nets | |
| March | 29, 2021 | Spurs | | Grizzlies | |
| March | 30, 2021 | Spurs | | Suns | |
| April | 1, 2021 | Rockets | | Spurs | |
| April | 3, 2021 | Spurs | | Wolves | |
| April | 4, 2021 | Raptors | | Spurs | |
| April | 7, 2021 | Suns | | Spurs | |
| April | 8, 2021 | Spurs | | 76ers | |
| April | 9, 2021 | Spurs | | Warriors | |
| April | 10, 2021 | Nuggets | | Spurs | |
| April | 11, 2021 | Spurs | | Blazers | |
| April | 12, 2021 | Spurs | | Jazz | |
| April | 13, 2021 | Wolves | | Spurs | |
| April | 14, 2021 | Spurs | | Raptors | |
| April | 16, 2021 | Spurs | | Suns | |
| April | 22, 2021 | Spurs | | Blazers | |
| April | 24, 2021 | Spurs | | Pacers | |
| April | 25, 2021 | Nuggets | | Spurs | |