| month | day | visitor | score | home | score |
|---|
| November | 3, 2027 | Nuggets | 94 | Spurs | 110 |
| November | 4, 2027 | Nuggets | 106 | Spurs | 95 |
| November | 5, 2027 | Kings | 75 | Spurs | 107 |
| November | 6, 2027 | Wolves | 90 | Spurs | 103 |
| November | 8, 2027 | Rockets | 115 | Spurs | 96 |
| November | 9, 2027 | Bucks | 80 | Spurs | 83 |
| November | 11, 2027 | Spurs | 88 | Nuggets | 89 |
| November | 14, 2027 | Sonics | 103 | Spurs | 94 |
| November | 15, 2027 | Mavericks | 85 | Spurs | 96 |
| November | 18, 2027 | Spurs | 117 | Suns | 106 |
| November | 20, 2027 | Spurs | 96 | Clippers | 91 |
| November | 26, 2027 | Kings | 87 | Spurs | 84 |
| November | 28, 2027 | Lakers | 107 | Spurs | 88 |
| November | 29, 2027 | Spurs | 112 | Lakers | 107 |
| December | 1, 2027 | Pelicans | 122 | Spurs | 102 |
| December | 3, 2027 | Spurs | 99 | Jazz | 113 |
| December | 7, 2027 | Spurs | 89 | Rockets | 116 |
| December | 10, 2027 | Spurs | 95 | Sonics | 111 |
| December | 11, 2027 | Suns | 111 | Spurs | 96 |
| December | 14, 2027 | Bulls | 99 | Spurs | 100 |
| December | 15, 2027 | Warriors | 85 | Spurs | 122 |
| December | 17, 2027 | Spurs | 94 | Sonics | 107 |
| December | 18, 2027 | Spurs | 116 | Mavericks | 81 |
| December | 22, 2027 | Nuggets | 92 | Spurs | 100 |
| December | 23, 2027 | Jazz | 111 | Spurs | 105 |
| December | 24, 2027 | Spurs | 78 | Pacers | 95 |
| December | 30, 2027 | Spurs | 85 | Sonics | 109 |
| December | 31, 2027 | Warriors | 105 | Spurs | 93 |
| January | 1, 2028 | Heat | 104 | Spurs | 96 |
| January | 7, 2028 | Grizzlies | 122 | Spurs | 102 |
| January | 9, 2028 | Spurs | 108 | Clippers | 117 |
| January | 14, 2028 | Spurs | 109 | Bucks | 91 |
| January | 15, 2028 | Spurs | 98 | Pelicans | 100 |
| January | 17, 2028 | Suns | 112 | Spurs | 116 |
| January | 18, 2028 | Knicks | 96 | Spurs | 109 |
| January | 19, 2028 | Spurs | 128 | Nets | 105 |
| January | 23, 2028 | Spurs | 111 | Suns | 113 |
| January | 24, 2028 | Spurs | 97 | Grizzlies | 137 |
| January | 26, 2028 | Spurs | 105 | Warriors | 117 |
| January | 27, 2028 | Spurs | 107 | Kings | 103 |
| January | 29, 2028 | Clippers | 97 | Spurs | 122 |
| January | 31, 2028 | Spurs | 98 | Lakers | 112 |
| February | 6, 2028 | Mavericks | | Spurs | |
| February | 7, 2028 | Spurs | | Clippers | |
| February | 8, 2028 | Spurs | | Knicks | |
| February | 12, 2028 | Spurs | | Lakers | |
| February | 13, 2028 | Sonics | | Spurs | |
| February | 21, 2028 | Sonics | | Spurs | |
| February | 22, 2028 | Spurs | | Wolves | |
| February | 26, 2028 | Spurs | | Celtics | |
| February | 27, 2028 | Spurs | | Lakers | |
| February | 28, 2028 | Spurs | | Wolves | |
| March | 1, 2028 | Rockets | | Spurs | |
| March | 5, 2028 | Mavericks | | Spurs | |
| March | 6, 2028 | Spurs | | Bulls | |
| March | 7, 2028 | Rockets | | Spurs | |
| March | 10, 2028 | 76ers | | Spurs | |
| March | 20, 2028 | Clippers | | Spurs | |
| March | 23, 2028 | Spurs | | Raptors | |
| March | 24, 2028 | Spurs | | Jazz | |
| March | 27, 2028 | Spurs | | Warriors | |
| March | 30, 2028 | Spurs | | Kings | |
| March | 31, 2028 | Lakers | | Spurs | |
| April | 2, 2028 | Nets | | Spurs | |
| April | 5, 2028 | Spurs | | Sonics | |
| April | 6, 2028 | Spurs | | Wolves | |
| April | 8, 2028 | Spurs | | Kings | |
| April | 9, 2028 | Spurs | | Heat | |
| April | 10, 2028 | Jazz | | Spurs | |
| April | 12, 2028 | Raptors | | Spurs | |
| April | 14, 2028 | Spurs | | 76ers | |
| April | 15, 2028 | Spurs | | Suns | |
| April | 17, 2028 | Kings | | Spurs | |
| April | 20, 2028 | Spurs | | Kings | |
| April | 24, 2028 | Suns | | Spurs | |
| April | 28, 2028 | Warriors | | Spurs | |
| April | 30, 2028 | Spurs | | Warriors | |
| May | 2, 2028 | Celtics | | Spurs | |
| May | 3, 2028 | Lakers | | Spurs | |
| May | 4, 2028 | Pacers | | Spurs | |
| May | 7, 2028 | Suns | | Spurs | |
| May | 9, 2028 | Spurs | | Clippers | |