| month | day | visitor | score | home | score |
|---|
| November | 2, 2027 | Lakers | 104 | Raptors | 137 |
| November | 5, 2027 | Sonics | 78 | Lakers | 102 |
| November | 6, 2027 | Lakers | 82 | Warriors | 84 |
| November | 8, 2027 | Jazz | 93 | Lakers | 103 |
| November | 9, 2027 | Lakers | 94 | Warriors | 96 |
| November | 11, 2027 | Nets | 101 | Lakers | 115 |
| November | 14, 2027 | Lakers | 103 | Nuggets | 99 |
| November | 19, 2027 | Lakers | 108 | Mavericks | 106 |
| November | 22, 2027 | Jazz | 111 | Lakers | 98 |
| November | 23, 2027 | Jazz | 106 | Lakers | 96 |
| November | 24, 2027 | Mavericks | 86 | Lakers | 107 |
| November | 25, 2027 | Clippers | 74 | Lakers | 105 |
| November | 28, 2027 | Lakers | 107 | Spurs | 88 |
| November | 29, 2027 | Spurs | 112 | Lakers | 107 |
| November | 30, 2027 | Lakers | 92 | Celtics | 101 |
| December | 4, 2027 | Rockets | 115 | Lakers | 99 |
| December | 5, 2027 | Lakers | 85 | Mavericks | 103 |
| December | 6, 2027 | Lakers | 106 | Nuggets | 110 |
| December | 7, 2027 | Lakers | 90 | Suns | 95 |
| December | 10, 2027 | Lakers | 84 | Kings | 96 |
| December | 14, 2027 | Knicks | 98 | Lakers | 104 |
| December | 15, 2027 | Lakers | 75 | Rockets | 105 |
| December | 17, 2027 | Lakers | 93 | Nuggets | 96 |
| December | 18, 2027 | Lakers | 85 | Grizzlies | 108 |
| December | 21, 2027 | Warriors | 74 | Lakers | 88 |
| December | 23, 2027 | Mavericks | 88 | Lakers | 91 |
| December | 24, 2027 | Lakers | 86 | Sonics | 74 |
| December | 25, 2027 | Wolves | 82 | Lakers | 103 |
| December | 26, 2027 | Lakers | 90 | Pacers | 87 |
| December | 28, 2027 | Lakers | 93 | Rockets | 111 |
| December | 31, 2027 | Suns | 65 | Lakers | 92 |
| January | 3, 2028 | Lakers | 91 | Bucks | 88 |
| January | 4, 2028 | Rockets | 80 | Lakers | 102 |
| January | 6, 2028 | Nuggets | 89 | Lakers | 96 |
| January | 7, 2028 | Warriors | 90 | Lakers | 95 |
| January | 8, 2028 | Wolves | 72 | Lakers | 98 |
| January | 9, 2028 | Pacers | 103 | Lakers | 107 |
| January | 10, 2028 | Kings | 83 | Lakers | 104 |
| January | 16, 2028 | Lakers | 78 | 76ers | 101 |
| January | 17, 2028 | Bucks | 84 | Lakers | 90 |
| January | 22, 2028 | Pelicans | 81 | Lakers | 84 |
| January | 23, 2028 | Lakers | 91 | Rockets | 96 |
| January | 31, 2028 | Spurs | 98 | Lakers | 112 |
| February | 2, 2028 | Lakers | | Wolves | |
| February | 4, 2028 | Lakers | | Sonics | |
| February | 5, 2028 | Lakers | | Rockets | |
| February | 6, 2028 | Lakers | | Jazz | |
| February | 8, 2028 | Lakers | | Jazz | |
| February | 9, 2028 | Lakers | | Mavericks | |
| February | 11, 2028 | Wolves | | Lakers | |
| February | 12, 2028 | Spurs | | Lakers | |
| February | 18, 2028 | Lakers | | Nets | |
| February | 20, 2028 | Lakers | | Nuggets | |
| February | 23, 2028 | Clippers | | Lakers | |
| February | 26, 2028 | Lakers | | Pelicans | |
| February | 27, 2028 | Spurs | | Lakers | |
| March | 2, 2028 | Lakers | | Heat | |
| March | 5, 2028 | Nuggets | | Lakers | |
| March | 12, 2028 | Kings | | Lakers | |
| March | 14, 2028 | Lakers | | Mavericks | |
| March | 16, 2028 | Kings | | Lakers | |
| March | 25, 2028 | Celtics | | Lakers | |
| March | 27, 2028 | Raptors | | Lakers | |
| March | 30, 2028 | Mavericks | | Lakers | |
| March | 31, 2028 | Lakers | | Spurs | |
| April | 1, 2028 | Nuggets | | Lakers | |
| April | 4, 2028 | Clippers | | Lakers | |
| April | 5, 2028 | Lakers | | Wolves | |
| April | 7, 2028 | Lakers | | Jazz | |
| April | 9, 2028 | Rockets | | Lakers | |
| April | 12, 2028 | Lakers | | Knicks | |
| April | 14, 2028 | Bulls | | Lakers | |
| April | 16, 2028 | Lakers | | Jazz | |
| April | 17, 2028 | Lakers | | Wolves | |
| April | 25, 2028 | Lakers | | Suns | |
| April | 27, 2028 | Grizzlies | | Lakers | |
| April | 28, 2028 | Lakers | | Clippers | |
| April | 29, 2028 | 76ers | | Lakers | |
| May | 1, 2028 | Heat | | Lakers | |
| May | 3, 2028 | Lakers | | Spurs | |
| May | 5, 2028 | Lakers | | Bulls | |
| May | 11, 2028 | Wolves | | Lakers | |