| month | day | visitor | score | home | score |
|---|
| November | 3, 2022 | Warriors | 82 | Lakers | 118 |
| November | 4, 2022 | Warriors | 105 | Lakers | 125 |
| November | 5, 2022 | Clippers | 109 | Lakers | 129 |
| November | 6, 2022 | Lakers | 111 | Hawks | 127 |
| November | 7, 2022 | Lakers | 111 | Jazz | 107 |
| November | 8, 2022 | Bulls | 116 | Lakers | 103 |
| November | 10, 2022 | Lakers | 122 | Clippers | 119 |
| November | 12, 2022 | Lakers | 112 | Nuggets | 120 |
| November | 13, 2022 | Lakers | 119 | Spurs | 124 |
| November | 14, 2022 | Lakers | 115 | Wolves | 132 |
| November | 15, 2022 | Kings | 116 | Lakers | 117 |
| November | 20, 2022 | Lakers | 89 | Bucks | 115 |
| November | 22, 2022 | Suns | 102 | Lakers | 109 |
| November | 23, 2022 | Lakers | 93 | Heat | 114 |
| November | 25, 2022 | Sonics | 121 | Lakers | 110 |
| November | 26, 2022 | Lakers | 116 | Warriors | 111 |
| December | 1, 2022 | Pelicans | 115 | Lakers | 129 |
| December | 3, 2022 | Rockets | 114 | Lakers | 93 |
| December | 5, 2022 | Lakers | 125 | Kings | 132 |
| December | 7, 2022 | Clippers | 111 | Lakers | 95 |
| December | 8, 2022 | Kings | 114 | Lakers | 110 |
| December | 12, 2022 | Lakers | 93 | Raptors | 111 |
| December | 14, 2022 | Lakers | 112 | Clippers | 106 |
| December | 15, 2022 | Grizzlies | 115 | Lakers | 109 |
| December | 19, 2022 | Jazz | 113 | Lakers | 108 |
| December | 21, 2022 | Sonics | 119 | Lakers | 126 |
| December | 23, 2022 | Knicks | 130 | Lakers | 104 |
| December | 24, 2022 | Clippers | 112 | Lakers | 116 |
| December | 25, 2022 | Lakers | 112 | Clippers | 132 |
| December | 29, 2022 | Lakers | 95 | Blazers | 107 |
| December | 31, 2022 | Lakers | 115 | Celtics | 120 |
| January | 2, 2023 | Rockets | 85 | Lakers | 82 |
| January | 5, 2023 | Lakers | 107 | Spurs | 93 |
| January | 6, 2023 | Heat | 102 | Lakers | 104 |
| January | 7, 2023 | Kings | 114 | Lakers | 120 |
| January | 8, 2023 | Lakers | 106 | Nets | 115 |
| January | 14, 2023 | Lakers | 107 | Mavericks | 116 |
| January | 15, 2023 | Lakers | 71 | Blazers | 101 |
| January | 16, 2023 | Raptors | 108 | Lakers | 127 |
| January | 18, 2023 | Lakers | 78 | Rockets | 115 |
| January | 20, 2023 | Lakers | 102 | Nuggets | 118 |
| January | 21, 2023 | Lakers | 85 | Kings | 119 |
| January | 23, 2023 | Lakers | 96 | Jazz | 119 |
| January | 31, 2023 | Lakers | 74 | Knicks | 119 |
| February | 1, 2023 | Sonics | 114 | Lakers | 95 |
| February | 8, 2023 | Nuggets | 107 | Lakers | 103 |
| February | 9, 2023 | 76ers | 87 | Lakers | 108 |
| February | 14, 2023 | Blazers | 108 | Lakers | 92 |
| February | 15, 2023 | Lakers | 92 | Warriors | 101 |
| February | 18, 2023 | Jazz | 111 | Lakers | 100 |
| February | 20, 2023 | Lakers | 83 | Rockets | 99 |
| February | 21, 2023 | Nets | 112 | Lakers | 97 |
| February | 22, 2023 | Lakers | 88 | Suns | 101 |
| February | 25, 2023 | Celtics | 122 | Lakers | 112 |
| February | 28, 2023 | Lakers | 114 | Pelicans | 122 |
| March | 1, 2023 | Lakers | 76 | 76ers | 83 |
| March | 2, 2023 | Wolves | 138 | Lakers | 98 |
| March | 3, 2023 | Lakers | 99 | Grizzlies | 119 |
| March | 6, 2023 | Mavericks | 111 | Lakers | 104 |
| March | 9, 2023 | Spurs | 93 | Lakers | 101 |
| March | 10, 2023 | Warriors | 94 | Lakers | 104 |
| March | 12, 2023 | Spurs | 96 | Lakers | 88 |
| March | 16, 2023 | Bucks | 103 | Lakers | 79 |
| March | 18, 2023 | Suns | 88 | Lakers | 87 |
| March | 19, 2023 | Nuggets | 114 | Lakers | 102 |
| March | 23, 2023 | Lakers | 87 | Sonics | 135 |
| March | 26, 2023 | Lakers | 88 | Kings | 102 |
| March | 27, 2023 | Wolves | 83 | Lakers | 111 |
| March | 28, 2023 | Lakers | 85 | Blazers | 95 |
| March | 31, 2023 | Pacers | 118 | Lakers | 111 |
| April | 2, 2023 | Lakers | 105 | Mavericks | 147 |
| April | 8, 2023 | Lakers | 129 | Bulls | 135 |
| April | 10, 2023 | Lakers | 93 | Pacers | 117 |
| April | 11, 2023 | Lakers | 123 | Warriors | 118 |
| April | 15, 2023 | Blazers | 105 | Lakers | 91 |
| April | 16, 2023 | Lakers | 92 | Sonics | 121 |
| April | 17, 2023 | Hawks | 105 | Lakers | 97 |
| April | 18, 2023 | Lakers | 101 | Suns | 92 |
| April | 21, 2023 | Lakers | 95 | Wolves | 118 |
| April | 22, 2023 | Lakers | 102 | Sonics | 111 |
| April | 23, 2023 | Mavericks | 115 | Lakers | 116 |
| April | 25, 2023 | Blazers | 114 | Lakers | 88 |