| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Knicks | 121 | Spurs | 102 |
| November | 5, 2021 | Spurs | 111 | Heat | 100 |
| November | 10, 2021 | Spurs | 118 | Wolves | 115 |
| November | 13, 2021 | Lakers | 120 | Spurs | 96 |
| November | 15, 2021 | Rockets | 87 | Spurs | 74 |
| November | 18, 2021 | Spurs | 114 | Mavericks | 129 |
| November | 19, 2021 | Grizzlies | 100 | Spurs | 105 |
| November | 22, 2021 | Jazz | 80 | Spurs | 106 |
| November | 27, 2021 | Jazz | 99 | Spurs | 120 |
| November | 29, 2021 | Suns | 108 | Spurs | 113 |
| December | 5, 2021 | Jazz | 106 | Spurs | 111 |
| December | 6, 2021 | Spurs | 118 | Clippers | 108 |
| December | 7, 2021 | Bucks | 95 | Spurs | 114 |
| December | 8, 2021 | Wolves | 103 | Spurs | 107 |
| December | 10, 2021 | Nuggets | 134 | Spurs | 109 |
| December | 11, 2021 | Warriors | 108 | Spurs | 133 |
| December | 13, 2021 | Hawks | 99 | Spurs | 109 |
| December | 15, 2021 | Spurs | 106 | Celtics | 120 |
| December | 17, 2021 | Spurs | 108 | Rockets | 128 |
| December | 20, 2021 | Spurs | 105 | Mavericks | 116 |
| December | 21, 2021 | Spurs | 106 | Pelicans | 127 |
| December | 22, 2021 | Mavericks | 122 | Spurs | 89 |
| December | 23, 2021 | Pacers | 97 | Spurs | 109 |
| December | 31, 2021 | Kings | 97 | Spurs | 99 |
| January | 1, 2022 | Blazers | 104 | Spurs | 90 |
| January | 2, 2022 | Nets | 96 | Spurs | 86 |
| January | 3, 2022 | Spurs | 85 | Kings | 98 |
| January | 5, 2022 | Lakers | 98 | Spurs | 113 |
| January | 7, 2022 | Spurs | 105 | Sonics | 126 |
| January | 8, 2022 | Sonics | 106 | Spurs | 119 |
| January | 9, 2022 | Spurs | 103 | Clippers | 117 |
| January | 11, 2022 | Clippers | 140 | Spurs | 99 |
| January | 14, 2022 | Spurs | 118 | Wolves | 123 |
| January | 17, 2022 | Spurs | 120 | Mavericks | 136 |
| January | 20, 2022 | Mavericks | 130 | Spurs | 124 |
| January | 21, 2022 | Clippers | 131 | Spurs | 113 |
| January | 25, 2022 | Spurs | 92 | Bulls | 104 |
| January | 27, 2022 | Spurs | 91 | Jazz | 110 |
| January | 28, 2022 | Blazers | 98 | Spurs | 106 |
| January | 29, 2022 | Spurs | 115 | Bucks | 117 |
| February | 1, 2022 | Kings | 84 | Spurs | 113 |
| February | 2, 2022 | Spurs | 116 | Nuggets | 127 |
| February | 4, 2022 | Heat | 91 | Spurs | 99 |
| February | 9, 2022 | Spurs | 119 | Jazz | 89 |
| February | 11, 2022 | Pelicans | 129 | Spurs | 115 |
| February | 12, 2022 | Warriors | 110 | Spurs | 129 |
| February | 13, 2022 | Spurs | 112 | Kings | 81 |
| February | 15, 2022 | Spurs | 107 | Rockets | 115 |
| February | 16, 2022 | Bulls | 134 | Spurs | 130 |
| February | 21, 2022 | Spurs | 101 | Nuggets | 119 |
| February | 24, 2022 | Wolves | 120 | Spurs | 105 |
| February | 26, 2022 | Spurs | 97 | Hawks | 123 |
| February | 28, 2022 | 76ers | 83 | Spurs | 101 |
| March | 2, 2022 | Spurs | 98 | Knicks | 130 |
| March | 3, 2022 | Spurs | 134 | Sonics | 109 |
| March | 4, 2022 | Spurs | 87 | Nuggets | 114 |
| March | 6, 2022 | Rockets | 129 | Spurs | 112 |
| March | 8, 2022 | Spurs | 122 | Suns | 108 |
| March | 9, 2022 | Spurs | 110 | Lakers | 98 |
| March | 11, 2022 | Sonics | 99 | Spurs | 107 |
| March | 12, 2022 | Spurs | 113 | Lakers | 110 |
| March | 15, 2022 | Mavericks | 128 | Spurs | 111 |
| March | 21, 2022 | Celtics | 137 | Spurs | 134 |
| March | 23, 2022 | Spurs | 110 | Warriors | 108 |
| March | 27, 2022 | Spurs | 113 | Nets | 123 |
| March | 29, 2022 | Spurs | 99 | Grizzlies | 106 |
| March | 30, 2022 | Spurs | 98 | Suns | 93 |
| April | 1, 2022 | Rockets | 127 | Spurs | 131 |
| April | 3, 2022 | Spurs | 79 | Wolves | 97 |
| April | 4, 2022 | Raptors | 118 | Spurs | 116 |
| April | 7, 2022 | Suns | 104 | Spurs | 111 |
| April | 8, 2022 | Spurs | 93 | 76ers | 76 |
| April | 9, 2022 | Spurs | 110 | Warriors | 89 |
| April | 10, 2022 | Nuggets | 123 | Spurs | 100 |
| April | 11, 2022 | Spurs | 105 | Blazers | 113 |
| April | 12, 2022 | Spurs | 126 | Jazz | 127 |
| April | 13, 2022 | Wolves | 106 | Spurs | 131 |
| April | 14, 2022 | Spurs | 106 | Raptors | 114 |
| April | 16, 2022 | Spurs | 120 | Suns | 111 |
| April | 22, 2022 | Spurs | 93 | Blazers | 97 |
| April | 24, 2022 | Spurs | 111 | Pacers | 121 |
| April | 25, 2022 | Nuggets | 100 | Spurs | 116 |
| Post | 1, 2022 | Spurs | 107 | Rockets | 136 |
| Post | 2, 2022 | Spurs | 108 | Rockets | 129 |
| Post | 3, 2022 | Rockets | 140 | Spurs | 113 |
| Post | 4, 2022 | Rockets | 117 | Spurs | 116 |
| Post | 5, 2022 | Spurs | | Rockets | |
| Post | 6, 2022 | Rockets | | Spurs | |
| Post | 7, 2022 | Spurs | | Rockets | |