| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Sonics | 112 | Kings | 113 |
| November | 5, 2021 | Sonics | 118 | Bucks | 127 |
| November | 7, 2021 | Kings | 85 | Sonics | 90 |
| November | 8, 2021 | Sonics | 108 | Raptors | 130 |
| November | 9, 2021 | Kings | 87 | Sonics | 102 |
| November | 10, 2021 | Jazz | 95 | Sonics | 96 |
| November | 11, 2021 | Sonics | 105 | Rockets | 118 |
| November | 12, 2021 | Sonics | 103 | Pelicans | 110 |
| November | 14, 2021 | Sonics | 115 | Warriors | 127 |
| November | 17, 2021 | Sonics | 112 | Clippers | 110 |
| November | 18, 2021 | Sonics | 107 | Nuggets | 111 |
| November | 21, 2021 | Sonics | 117 | Warriors | 102 |
| November | 25, 2021 | Sonics | 96 | Lakers | 125 |
| November | 30, 2021 | Wolves | 117 | Sonics | 107 |
| December | 2, 2021 | Sonics | 97 | Jazz | 84 |
| December | 5, 2021 | Warriors | 85 | Sonics | 118 |
| December | 6, 2021 | Sonics | 90 | Knicks | 121 |
| December | 7, 2021 | Blazers | 99 | Sonics | 94 |
| December | 8, 2021 | Bucks | 118 | Sonics | 127 |
| December | 11, 2021 | Sonics | 76 | Blazers | 100 |
| December | 13, 2021 | Jazz | 102 | Sonics | 113 |
| December | 14, 2021 | Blazers | 100 | Sonics | 116 |
| December | 16, 2021 | Heat | 111 | Sonics | 108 |
| December | 19, 2021 | Rockets | 116 | Sonics | 105 |
| December | 20, 2021 | Warriors | 121 | Sonics | 141 |
| December | 21, 2021 | Sonics | 132 | Lakers | 115 |
| December | 25, 2021 | Blazers | 115 | Sonics | 107 |
| December | 26, 2021 | Sonics | 130 | Bulls | 132 |
| December | 27, 2021 | Warriors | 108 | Sonics | 127 |
| December | 31, 2021 | Sonics | 105 | Suns | 129 |
| January | 1, 2022 | Sonics | 82 | Kings | 89 |
| January | 2, 2022 | Sonics | 114 | Blazers | 107 |
| January | 6, 2022 | Sonics | 102 | Nuggets | 110 |
| January | 7, 2022 | Spurs | 105 | Sonics | 126 |
| January | 8, 2022 | Sonics | 106 | Spurs | 119 |
| January | 9, 2022 | Nuggets | 100 | Sonics | 130 |
| January | 12, 2022 | Sonics | 119 | Warriors | 104 |
| January | 13, 2022 | Sonics | 82 | Rockets | 113 |
| January | 15, 2022 | Sonics | 135 | Hawks | 126 |
| January | 18, 2022 | Sonics | 100 | Wolves | 112 |
| January | 19, 2022 | Grizzlies | 103 | Sonics | 95 |
| January | 23, 2022 | Sonics | 89 | Nets | 107 |
| January | 25, 2022 | Mavericks | 101 | Sonics | 114 |
| January | 27, 2022 | Celtics | 113 | Sonics | 111 |
| January | 30, 2022 | Hawks | 122 | Sonics | 107 |
| January | 31, 2022 | 76ers | 75 | Sonics | 85 |
| February | 1, 2022 | Sonics | 103 | Lakers | 114 |
| February | 8, 2022 | Sonics | 108 | Jazz | 111 |
| February | 10, 2022 | Sonics | 109 | Warriors | 98 |
| February | 11, 2022 | Sonics | 90 | Blazers | 91 |
| February | 13, 2022 | Sonics | 103 | Pacers | 109 |
| February | 21, 2022 | Sonics | 115 | Clippers | 134 |
| March | 2, 2022 | Sonics | 112 | Clippers | 139 |
| March | 3, 2022 | Spurs | 134 | Sonics | 109 |
| March | 5, 2022 | Rockets | 116 | Sonics | 117 |
| March | 6, 2022 | Raptors | 121 | Sonics | 104 |
| March | 8, 2022 | Sonics | 73 | Heat | 102 |
| March | 11, 2022 | Sonics | 99 | Spurs | 107 |
| March | 12, 2022 | Sonics | 79 | Kings | 91 |
| March | 17, 2022 | Pelicans | 85 | Sonics | 118 |
| March | 19, 2022 | Sonics | 112 | Suns | 108 |
| March | 20, 2022 | Sonics | 109 | Grizzlies | 114 |
| March | 22, 2022 | Clippers | 131 | Sonics | 103 |
| March | 23, 2022 | Lakers | 108 | Sonics | 110 |
| March | 25, 2022 | Kings | 102 | Sonics | 90 |
| March | 27, 2022 | Sonics | 110 | Mavericks | 136 |
| March | 28, 2022 | Suns | 109 | Sonics | 105 |
| March | 30, 2022 | Sonics | 82 | 76ers | 97 |
| April | 2, 2022 | Clippers | 122 | Sonics | 123 |
| April | 3, 2022 | Nuggets | 111 | Sonics | 96 |
| April | 4, 2022 | Pacers | 95 | Sonics | 121 |
| April | 5, 2022 | Nets | 94 | Sonics | 106 |
| April | 6, 2022 | Sonics | 118 | Celtics | 124 |
| April | 9, 2022 | Mavericks | 111 | Sonics | 122 |
| April | 10, 2022 | Suns | 102 | Sonics | 110 |
| April | 16, 2022 | Lakers | 105 | Sonics | 111 |
| April | 17, 2022 | Sonics | 85 | Mavericks | 121 |
| April | 18, 2022 | Bulls | 109 | Sonics | 103 |
| April | 20, 2022 | Knicks | 112 | Sonics | 101 |
| April | 22, 2022 | Lakers | 120 | Sonics | 113 |
| April | 24, 2022 | Wolves | 115 | Sonics | 97 |
| April | 25, 2022 | Clippers | 119 | Sonics | 108 |