| month | day | visitor | score | home | score |
|---|
| November | 9, 2021 | Rockets | 109 | Warriors | 79 |
| November | 11, 2021 | Sonics | 105 | Rockets | 118 |
| November | 12, 2021 | Rockets | 95 | Heat | 97 |
| November | 14, 2021 | Rockets | 107 | Suns | 104 |
| November | 15, 2021 | Rockets | 87 | Spurs | 74 |
| November | 16, 2021 | Wolves | 83 | Rockets | 93 |
| November | 18, 2021 | Rockets | 105 | Celtics | 118 |
| November | 20, 2021 | Rockets | 81 | Nuggets | 123 |
| November | 23, 2021 | Rockets | 95 | Wolves | 103 |
| November | 24, 2021 | Mavericks | 121 | Rockets | 127 |
| November | 26, 2021 | Rockets | 110 | Blazers | 96 |
| November | 27, 2021 | Raptors | 97 | Rockets | 113 |
| November | 29, 2021 | Rockets | 127 | Warriors | 101 |
| November | 30, 2021 | Jazz | 106 | Rockets | 148 |
| December | 1, 2021 | Rockets | 117 | Nuggets | 111 |
| December | 3, 2021 | Rockets | 84 | Lakers | 81 |
| December | 4, 2021 | Rockets | 96 | 76ers | 77 |
| December | 10, 2021 | Warriors | 105 | Rockets | 121 |
| December | 12, 2021 | Clippers | 114 | Rockets | 123 |
| December | 15, 2021 | Kings | 92 | Rockets | 105 |
| December | 17, 2021 | Spurs | 108 | Rockets | 128 |
| December | 19, 2021 | Rockets | 116 | Sonics | 105 |
| December | 21, 2021 | Kings | 102 | Rockets | 113 |
| December | 22, 2021 | Pacers | 120 | Rockets | 136 |
| December | 25, 2021 | Rockets | 113 | Suns | 97 |
| December | 26, 2021 | Suns | 98 | Rockets | 133 |
| December | 27, 2021 | Rockets | 108 | Jazz | 93 |
| December | 30, 2021 | Bulls | 129 | Rockets | 118 |
| December | 31, 2021 | Mavericks | 101 | Rockets | 93 |
| January | 1, 2022 | Clippers | 104 | Rockets | 130 |
| January | 2, 2022 | Rockets | 128 | Lakers | 117 |
| January | 3, 2022 | Nuggets | 110 | Rockets | 106 |
| January | 4, 2022 | Rockets | 112 | Suns | 100 |
| January | 6, 2022 | Hawks | 114 | Rockets | 124 |
| January | 8, 2022 | Suns | 112 | Rockets | 109 |
| January | 10, 2022 | Pelicans | 112 | Rockets | 132 |
| January | 12, 2022 | Heat | 85 | Rockets | 124 |
| January | 13, 2022 | Sonics | 82 | Rockets | 113 |
| January | 14, 2022 | Nuggets | 97 | Rockets | 102 |
| January | 15, 2022 | Mavericks | 119 | Rockets | 123 |
| January | 18, 2022 | Lakers | 88 | Rockets | 136 |
| January | 20, 2022 | Rockets | 107 | Pelicans | 106 |
| January | 22, 2022 | Rockets | 122 | Mavericks | 107 |
| January | 24, 2022 | Rockets | 92 | Kings | 98 |
| January | 25, 2022 | 76ers | 77 | Rockets | 113 |
| January | 26, 2022 | Rockets | 127 | Grizzlies | 125 |
| January | 29, 2022 | Rockets | 94 | Kings | 83 |
| February | 1, 2022 | Rockets | 145 | Raptors | 118 |
| February | 2, 2022 | Rockets | 124 | Jazz | 125 |
| February | 8, 2022 | Blazers | 97 | Rockets | 112 |
| February | 14, 2022 | Rockets | 128 | Knicks | 123 |
| February | 15, 2022 | Spurs | 107 | Rockets | 115 |
| February | 16, 2022 | Jazz | 115 | Rockets | 121 |
| February | 19, 2022 | Rockets | 124 | Mavericks | 110 |
| February | 20, 2022 | Lakers | 100 | Rockets | 143 |
| February | 26, 2022 | Rockets | 115 | Wolves | 122 |
| February | 27, 2022 | Jazz | 100 | Rockets | 117 |
| March | 3, 2022 | Rockets | 123 | Bucks | 117 |
| March | 4, 2022 | Rockets | 135 | Hawks | 116 |
| March | 5, 2022 | Rockets | 116 | Sonics | 117 |
| March | 6, 2022 | Rockets | 129 | Spurs | 112 |
| March | 8, 2022 | Grizzlies | 117 | Rockets | 137 |
| March | 9, 2022 | Rockets | 101 | Blazers | 97 |
| March | 10, 2022 | Nets | 73 | Rockets | 99 |
| March | 12, 2022 | Blazers | 97 | Rockets | 101 |
| March | 13, 2022 | Rockets | 118 | Mavericks | 111 |
| March | 14, 2022 | Wolves | 101 | Rockets | 127 |
| March | 16, 2022 | Suns | 108 | Rockets | 122 |
| March | 20, 2022 | Nuggets | 115 | Rockets | 130 |
| March | 22, 2022 | Warriors | 106 | Rockets | 144 |
| March | 25, 2022 | Knicks | 136 | Rockets | 131 |
| March | 27, 2022 | Rockets | 114 | Bulls | 123 |
| March | 28, 2022 | Rockets | 120 | Nets | 108 |
| March | 30, 2022 | Rockets | 122 | Clippers | 156 |
| March | 31, 2022 | Wolves | 123 | Rockets | 133 |
| April | 1, 2022 | Rockets | 127 | Spurs | 131 |
| April | 3, 2022 | Bucks | 111 | Rockets | 133 |
| April | 7, 2022 | Rockets | 123 | Wolves | 109 |
| April | 8, 2022 | Rockets | 132 | Jazz | 128 |
| April | 17, 2022 | Rockets | 129 | Clippers | 127 |
| April | 23, 2022 | Rockets | 127 | Pacers | 123 |
| April | 26, 2022 | Celtics | 142 | Rockets | 140 |
| Post | 1, 2022 | Spurs | 107 | Rockets | 136 |
| Post | 2, 2022 | Spurs | 108 | Rockets | 129 |
| Post | 3, 2022 | Rockets | 140 | Spurs | 113 |
| Post | 4, 2022 | Rockets | 117 | Spurs | 116 |
| Post | 5, 2022 | Spurs | | Rockets | |
| Post | 6, 2022 | Rockets | | Spurs | |
| Post | 7, 2022 | Spurs | | Rockets | |
| Post | 8, 2022 | Nuggets | 122 | Rockets | 123 |
| Post | 9, 2022 | Nuggets | 122 | Rockets | 127 |
| Post | 10, 2022 | Rockets | 120 | Nuggets | 126 |
| Post | 11, 2022 | Rockets | 115 | Nuggets | 109 |
| Post | 12, 2022 | Nuggets | 103 | Rockets | 116 |
| Post | 13, 2022 | Rockets | | Nuggets | |
| Post | 14, 2022 | Nuggets | | Rockets | |
| Post | 15, 2022 | Clippers | 131 | Rockets | 146 |
| Post | 16, 2022 | Clippers | 115 | Rockets | 136 |
| Post | 17, 2022 | Rockets | 145 | Clippers | 152 |
| Post | 18, 2022 | Rockets | 113 | Clippers | 129 |
| Post | 19, 2022 | Clippers | 114 | Rockets | 138 |
| Post | 20, 2022 | Rockets | 120 | Clippers | 135 |
| Post | 21, 2022 | Clippers | 111 | Rockets | 114 |
| Post | 22, 2022 | Pelicans | 100 | Rockets | 108 |
| Post | 23, 2022 | Pelicans | 97 | Rockets | 123 |
| Post | 24, 2022 | Rockets | 134 | Pelicans | 108 |
| Post | 25, 2022 | Rockets | 126 | Pelicans | 135 |
| Post | 26, 2022 | Rockets | 107 | Pelicans | 115 |
| Post | 27, 2022 | Pelicans | 82 | Rockets | 115 |