| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Raptors | 107 | Mavericks | 112 |
| November | 3, 2021 | Hawks | 129 | Raptors | 143 |
| November | 5, 2021 | Nuggets | 111 | Raptors | 117 |
| November | 6, 2021 | Celtics | 134 | Raptors | 126 |
| November | 8, 2021 | Sonics | 108 | Raptors | 130 |
| November | 9, 2021 | Raptors | 122 | Hawks | 149 |
| November | 11, 2021 | Raptors | 126 | Nets | 116 |
| November | 13, 2021 | Raptors | 104 | Pacers | 110 |
| November | 14, 2021 | Raptors | 123 | Celtics | 122 |
| November | 16, 2021 | Raptors | 134 | Pacers | 124 |
| November | 17, 2021 | Raptors | 132 | Knicks | 133 |
| November | 19, 2021 | Raptors | 108 | Pacers | 105 |
| November | 20, 2021 | Raptors | 120 | Bulls | 106 |
| November | 21, 2021 | Wolves | 102 | Raptors | 128 |
| November | 23, 2021 | Raptors | 123 | Warriors | 120 |
| November | 24, 2021 | Raptors | 118 | Celtics | 128 |
| November | 27, 2021 | Raptors | 97 | Rockets | 113 |
| November | 29, 2021 | Jazz | 104 | Raptors | 121 |
| December | 1, 2021 | Raptors | 119 | Heat | 101 |
| December | 4, 2021 | Raptors | 115 | Hawks | 105 |
| December | 8, 2021 | Warriors | 103 | Raptors | 131 |
| December | 9, 2021 | Bulls | 92 | Raptors | 136 |
| December | 10, 2021 | Raptors | 118 | Blazers | 117 |
| December | 12, 2021 | Lakers | 106 | Raptors | 137 |
| December | 14, 2021 | Knicks | 95 | Raptors | 105 |
| December | 18, 2021 | Raptors | 110 | Grizzlies | 120 |
| December | 19, 2021 | Hawks | 129 | Raptors | 132 |
| December | 21, 2021 | Raptors | 118 | 76ers | 103 |
| December | 22, 2021 | Bucks | 97 | Raptors | 147 |
| December | 23, 2021 | Raptors | 124 | Wolves | 108 |
| December | 24, 2021 | Grizzlies | 143 | Raptors | 131 |
| December | 26, 2021 | Raptors | 115 | Knicks | 132 |
| December | 27, 2021 | Raptors | 146 | Bucks | 134 |
| December | 28, 2021 | Clippers | 124 | Raptors | 128 |
| January | 4, 2022 | Knicks | 113 | Raptors | 92 |
| January | 7, 2022 | Nets | 110 | Raptors | 107 |
| January | 12, 2022 | Raptors | 111 | Bucks | 126 |
| January | 14, 2022 | Raptors | 96 | Grizzlies | 111 |
| January | 16, 2022 | Raptors | 134 | Lakers | 119 |
| January | 18, 2022 | Heat | 115 | Raptors | 125 |
| January | 22, 2022 | Pacers | 121 | Raptors | 126 |
| January | 26, 2022 | Kings | 96 | Raptors | 110 |
| January | 29, 2022 | Raptors | 120 | Clippers | 139 |
| January | 31, 2022 | Raptors | 125 | Nets | 126 |
| February | 1, 2022 | Rockets | 145 | Raptors | 118 |
| February | 2, 2022 | Pelicans | 125 | Raptors | 131 |
| February | 4, 2022 | Raptors | 126 | Hawks | 128 |
| February | 8, 2022 | 76ers | 117 | Raptors | 111 |
| February | 10, 2022 | Nets | 126 | Raptors | 106 |
| February | 11, 2022 | Raptors | 114 | 76ers | 115 |
| February | 12, 2022 | Bulls | 126 | Raptors | 110 |
| February | 14, 2022 | Grizzlies | 109 | Raptors | 121 |
| February | 15, 2022 | Mavericks | 105 | Raptors | 106 |
| February | 16, 2022 | Suns | 99 | Raptors | 120 |
| February | 19, 2022 | Celtics | 133 | Raptors | 112 |
| February | 20, 2022 | Hawks | 116 | Raptors | 129 |
| February | 23, 2022 | Raptors | 113 | Nuggets | 135 |
| February | 24, 2022 | Raptors | 95 | Kings | 112 |
| March | 1, 2022 | Pacers | 105 | Raptors | 119 |
| March | 2, 2022 | Raptors | 101 | Suns | 115 |
| March | 4, 2022 | Raptors | 114 | Bulls | 109 |
| March | 5, 2022 | Pelicans | 106 | Raptors | 111 |
| March | 6, 2022 | Raptors | 121 | Sonics | 104 |
| March | 9, 2022 | Bucks | 119 | Raptors | 139 |
| March | 10, 2022 | Pacers | 99 | Raptors | 114 |
| March | 13, 2022 | Blazers | 122 | Raptors | 129 |
| March | 14, 2022 | Raptors | 117 | Grizzlies | 126 |
| March | 16, 2022 | Raptors | 105 | 76ers | 112 |
| March | 17, 2022 | Raptors | 113 | Jazz | 134 |
| March | 18, 2022 | Grizzlies | 105 | Raptors | 117 |
| March | 22, 2022 | Raptors | 122 | Heat | 109 |
| March | 24, 2022 | Pacers | 125 | Raptors | 98 |
| March | 25, 2022 | Bucks | 128 | Raptors | 116 |
| March | 26, 2022 | Heat | 107 | Raptors | 110 |
| March | 31, 2022 | 76ers | 91 | Raptors | 88 |
| April | 4, 2022 | Raptors | 118 | Spurs | 116 |
| April | 5, 2022 | Raptors | 103 | Pelicans | 120 |
| April | 14, 2022 | Spurs | 106 | Raptors | 114 |
| April | 15, 2022 | Raptors | 131 | Bulls | 124 |
| April | 20, 2022 | Raptors | 105 | Pelicans | 135 |
| April | 23, 2022 | Raptors | 118 | Bucks | 112 |
| April | 24, 2022 | Bulls | 133 | Raptors | 113 |
| Post | 1, 2022 | Raptors | 105 | Knicks | 103 |
| Post | 2, 2022 | Raptors | 122 | Knicks | 124 |
| Post | 3, 2022 | Knicks | 134 | Raptors | 111 |
| Post | 4, 2022 | Knicks | 123 | Raptors | 105 |
| Post | 5, 2022 | Raptors | 102 | Knicks | 94 |
| Post | 6, 2022 | Knicks | 127 | Raptors | 115 |
| Post | 7, 2022 | Raptors | | Knicks | |