| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Pelicans | 117 | Heat | 123 |
| November | 7, 2021 | Warriors | 111 | Pelicans | 133 |
| November | 9, 2021 | Heat | 114 | Pelicans | 100 |
| November | 12, 2021 | Sonics | 103 | Pelicans | 110 |
| November | 13, 2021 | Knicks | 92 | Pelicans | 103 |
| November | 17, 2021 | Pelicans | 127 | Suns | 109 |
| November | 20, 2021 | Blazers | 94 | Pelicans | 108 |
| November | 23, 2021 | Pelicans | 106 | Grizzlies | 115 |
| November | 25, 2021 | Clippers | 81 | Pelicans | 133 |
| November | 26, 2021 | Pelicans | 116 | Knicks | 127 |
| November | 27, 2021 | Grizzlies | 96 | Pelicans | 110 |
| December | 1, 2021 | Pelicans | 131 | Lakers | 109 |
| December | 3, 2021 | Pelicans | 102 | Heat | 87 |
| December | 6, 2021 | Bucks | 146 | Pelicans | 157 |
| December | 7, 2021 | Bulls | 117 | Pelicans | 119 |
| December | 8, 2021 | Celtics | 142 | Pelicans | 133 |
| December | 11, 2021 | Pelicans | 122 | Clippers | 120 |
| December | 12, 2021 | Kings | 101 | Pelicans | 98 |
| December | 14, 2021 | Pelicans | 124 | Bulls | 108 |
| December | 16, 2021 | Wolves | 110 | Pelicans | 120 |
| December | 17, 2021 | Hawks | 116 | Pelicans | 127 |
| December | 18, 2021 | Pelicans | 133 | 76ers | 112 |
| December | 21, 2021 | Spurs | 106 | Pelicans | 127 |
| December | 23, 2021 | 76ers | 82 | Pelicans | 121 |
| December | 24, 2021 | Pelicans | 156 | Celtics | 115 |
| December | 26, 2021 | Pelicans | 104 | Blazers | 100 |
| December | 30, 2021 | Pacers | 96 | Pelicans | 129 |
| January | 1, 2022 | Pelicans | 119 | Bucks | 123 |
| January | 3, 2022 | Pacers | 116 | Pelicans | 111 |
| January | 5, 2022 | Pelicans | 141 | Celtics | 135 |
| January | 10, 2022 | Pelicans | 112 | Rockets | 132 |
| January | 11, 2022 | Pacers | 93 | Pelicans | 121 |
| January | 16, 2022 | Nets | 115 | Pelicans | 100 |
| January | 17, 2022 | Pelicans | 113 | Hawks | 127 |
| January | 19, 2022 | Suns | 115 | Pelicans | 132 |
| January | 20, 2022 | Rockets | 107 | Pelicans | 106 |
| January | 26, 2022 | Pelicans | 136 | Bulls | 114 |
| February | 2, 2022 | Pelicans | 125 | Raptors | 131 |
| February | 9, 2022 | Pelicans | 81 | Kings | 89 |
| February | 11, 2022 | Pelicans | 129 | Spurs | 115 |
| February | 12, 2022 | Mavericks | 117 | Pelicans | 119 |
| February | 13, 2022 | Celtics | 99 | Pelicans | 131 |
| February | 14, 2022 | Pelicans | 107 | 76ers | 77 |
| February | 18, 2022 | Pelicans | 102 | Nuggets | 121 |
| February | 22, 2022 | Pelicans | 96 | Mavericks | 128 |
| February | 24, 2022 | Celtics | 105 | Pelicans | 150 |
| February | 25, 2022 | Knicks | 112 | Pelicans | 131 |
| February | 26, 2022 | Heat | 104 | Pelicans | 110 |
| February | 27, 2022 | Pelicans | 107 | Pacers | 112 |
| February | 28, 2022 | Lakers | 85 | Pelicans | 119 |
| March | 5, 2022 | Pelicans | 106 | Raptors | 111 |
| March | 6, 2022 | Pelicans | 95 | Nets | 129 |
| March | 8, 2022 | Pelicans | 110 | Bulls | 126 |
| March | 12, 2022 | 76ers | 97 | Pelicans | 109 |
| March | 13, 2022 | Pelicans | 115 | Grizzlies | 116 |
| March | 15, 2022 | Nuggets | 115 | Pelicans | 102 |
| March | 16, 2022 | Pelicans | 98 | Nets | 109 |
| March | 17, 2022 | Pelicans | 85 | Sonics | 118 |
| March | 19, 2022 | Knicks | 122 | Pelicans | 104 |
| March | 21, 2022 | Nets | 110 | Pelicans | 101 |
| March | 24, 2022 | Pelicans | 86 | Grizzlies | 105 |
| March | 26, 2022 | Pelicans | 112 | Celtics | 119 |
| March | 27, 2022 | Pelicans | 89 | 76ers | 79 |
| March | 28, 2022 | Pelicans | 95 | Heat | 109 |
| March | 31, 2022 | Pelicans | 105 | Knicks | 133 |
| April | 1, 2022 | Pelicans | 106 | Pacers | 115 |
| April | 2, 2022 | Nets | 100 | Pelicans | 103 |
| April | 4, 2022 | Hawks | 119 | Pelicans | 118 |
| April | 5, 2022 | Raptors | 103 | Pelicans | 120 |
| April | 8, 2022 | Heat | 94 | Pelicans | 98 |
| April | 9, 2022 | Pelicans | 116 | Hawks | 103 |
| April | 10, 2022 | Nets | 108 | Pelicans | 107 |
| April | 11, 2022 | Knicks | 124 | Pelicans | 113 |
| April | 12, 2022 | Pelicans | 98 | Warriors | 104 |
| April | 13, 2022 | 76ers | 89 | Pelicans | 98 |
| April | 14, 2022 | Pelicans | 109 | Jazz | 112 |
| April | 19, 2022 | Pelicans | 119 | Wolves | 115 |
| April | 20, 2022 | Raptors | 105 | Pelicans | 135 |
| April | 22, 2022 | Pelicans | 102 | Bucks | 139 |
| April | 23, 2022 | Jazz | 100 | Pelicans | 108 |
| April | 25, 2022 | Pelicans | 120 | Bucks | 138 |
| April | 26, 2022 | Hawks | 127 | Pelicans | 105 |
| Post | 1, 2022 | Pelicans | 91 | Celtics | 135 |
| Post | 2, 2022 | Pelicans | 106 | Celtics | 137 |
| Post | 3, 2022 | Celtics | 116 | Pelicans | 117 |
| Post | 4, 2022 | Celtics | 99 | Pelicans | 124 |
| Post | 5, 2022 | Pelicans | 110 | Celtics | 116 |
| Post | 6, 2022 | Celtics | 100 | Pelicans | 148 |
| Post | 7, 2022 | Pelicans | 135 | Celtics | 122 |
| Post | 8, 2022 | Pelicans | 119 | Knicks | 115 |
| Post | 9, 2022 | Pelicans | 116 | Knicks | 129 |
| Post | 10, 2022 | Knicks | 123 | Pelicans | 128 |
| Post | 11, 2022 | Knicks | 111 | Pelicans | 124 |
| Post | 12, 2022 | Pelicans | 126 | Knicks | 117 |
| Post | 13, 2022 | Knicks | | Pelicans | |
| Post | 14, 2022 | Pelicans | | Knicks | |
| Post | 15, 2022 | Pelicans | 129 | Bulls | 114 |
| Post | 16, 2022 | Pelicans | 113 | Bulls | 95 |
| Post | 17, 2022 | Bulls | 126 | Pelicans | 120 |
| Post | 18, 2022 | Bulls | 106 | Pelicans | 128 |
| Post | 19, 2022 | Pelicans | 105 | Bulls | 112 |
| Post | 20, 2022 | Bulls | 121 | Pelicans | 103 |
| Post | 21, 2022 | Pelicans | 121 | Bulls | 98 |
| Post | 22, 2022 | Pelicans | 100 | Rockets | 108 |
| Post | 23, 2022 | Pelicans | 97 | Rockets | 123 |
| Post | 24, 2022 | Rockets | 134 | Pelicans | 108 |
| Post | 25, 2022 | Rockets | 126 | Pelicans | 135 |
| Post | 26, 2022 | Rockets | 107 | Pelicans | 115 |
| Post | 27, 2022 | Pelicans | 82 | Rockets | 115 |