| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Bucks | 132 | Pacers | 122 |
| November | 4, 2021 | Pacers | 131 | Clippers | 122 |
| November | 9, 2021 | Bucks | 123 | Pacers | 122 |
| November | 11, 2021 | Kings | 117 | Pacers | 114 |
| November | 12, 2021 | Pacers | 97 | Bucks | 130 |
| November | 13, 2021 | Raptors | 104 | Pacers | 110 |
| November | 16, 2021 | Raptors | 134 | Pacers | 124 |
| November | 17, 2021 | Pacers | 89 | Blazers | 137 |
| November | 19, 2021 | Raptors | 108 | Pacers | 105 |
| November | 22, 2021 | 76ers | 109 | Pacers | 103 |
| November | 25, 2021 | Mavericks | 115 | Pacers | 98 |
| November | 28, 2021 | Hawks | 135 | Pacers | 122 |
| November | 29, 2021 | Pacers | 100 | 76ers | 93 |
| December | 1, 2021 | Clippers | 124 | Pacers | 115 |
| December | 2, 2021 | Hawks | 132 | Pacers | 127 |
| December | 9, 2021 | Pacers | 102 | Knicks | 132 |
| December | 11, 2021 | Knicks | 100 | Pacers | 108 |
| December | 12, 2021 | Grizzlies | 116 | Pacers | 101 |
| December | 13, 2021 | Warriors | 120 | Pacers | 113 |
| December | 16, 2021 | Hawks | 128 | Pacers | 104 |
| December | 18, 2021 | Bucks | 132 | Pacers | 119 |
| December | 22, 2021 | Pacers | 120 | Rockets | 136 |
| December | 23, 2021 | Pacers | 97 | Spurs | 109 |
| December | 24, 2021 | Bulls | 97 | Pacers | 106 |
| December | 27, 2021 | Pacers | 98 | Nuggets | 113 |
| December | 30, 2021 | Pacers | 96 | Pelicans | 129 |
| January | 3, 2022 | Pacers | 116 | Pelicans | 111 |
| January | 6, 2022 | Pacers | 93 | Suns | 102 |
| January | 11, 2022 | Pacers | 93 | Pelicans | 121 |
| January | 13, 2022 | Grizzlies | 116 | Pacers | 109 |
| January | 15, 2022 | Pacers | 82 | Nets | 158 |
| January | 17, 2022 | Knicks | 109 | Pacers | 98 |
| January | 18, 2022 | Bucks | 122 | Pacers | 113 |
| January | 20, 2022 | Nets | 120 | Pacers | 114 |
| January | 21, 2022 | Pacers | 86 | Hawks | 117 |
| January | 22, 2022 | Pacers | 121 | Raptors | 126 |
| January | 23, 2022 | Pacers | 111 | Grizzlies | 116 |
| January | 26, 2022 | Blazers | 103 | Pacers | 115 |
| January | 27, 2022 | Nets | 109 | Pacers | 101 |
| January | 28, 2022 | Celtics | 102 | Pacers | 107 |
| February | 1, 2022 | Pacers | 99 | Bulls | 116 |
| February | 2, 2022 | Pacers | 103 | Bucks | 138 |
| February | 4, 2022 | Pacers | 116 | Knicks | 122 |
| February | 9, 2022 | Heat | 97 | Pacers | 91 |
| February | 13, 2022 | Sonics | 103 | Pacers | 109 |
| February | 15, 2022 | Heat | 97 | Pacers | 107 |
| February | 18, 2022 | Bulls | 121 | Pacers | 123 |
| February | 21, 2022 | Grizzlies | 106 | Pacers | 115 |
| February | 22, 2022 | Bulls | 114 | Pacers | 118 |
| February | 23, 2022 | Pacers | 103 | Heat | 136 |
| February | 25, 2022 | Pacers | 106 | Jazz | 107 |
| February | 27, 2022 | Pelicans | 107 | Pacers | 112 |
| February | 28, 2022 | Pacers | 120 | Warriors | 121 |
| March | 1, 2022 | Pacers | 105 | Raptors | 119 |
| March | 2, 2022 | Jazz | 107 | Pacers | 110 |
| March | 7, 2022 | Suns | 104 | Pacers | 119 |
| March | 10, 2022 | Pacers | 99 | Raptors | 114 |
| March | 13, 2022 | Pacers | 105 | Nets | 117 |
| March | 15, 2022 | Pacers | 113 | Hawks | 122 |
| March | 16, 2022 | Pacers | 90 | Celtics | 117 |
| March | 18, 2022 | Pacers | 107 | Kings | 100 |
| March | 23, 2022 | Pacers | 99 | Bucks | 127 |
| March | 24, 2022 | Pacers | 125 | Raptors | 98 |
| March | 25, 2022 | Celtics | 130 | Pacers | 106 |
| March | 26, 2022 | Pacers | 94 | Wolves | 115 |
| March | 28, 2022 | Pacers | 104 | Bulls | 108 |
| March | 29, 2022 | 76ers | 115 | Pacers | 113 |
| March | 31, 2022 | Pacers | 94 | Lakers | 104 |
| April | 1, 2022 | Pelicans | 106 | Pacers | 115 |
| April | 2, 2022 | Pacers | 126 | Bucks | 118 |
| April | 4, 2022 | Pacers | 95 | Sonics | 121 |
| April | 5, 2022 | Pacers | 105 | Mavericks | 114 |
| April | 7, 2022 | Pacers | 118 | Grizzlies | 120 |
| April | 8, 2022 | Nuggets | 121 | Pacers | 104 |
| April | 10, 2022 | Lakers | 104 | Pacers | 134 |
| April | 11, 2022 | Pacers | 97 | Heat | 102 |
| April | 12, 2022 | Pacers | 109 | 76ers | 101 |
| April | 16, 2022 | Pacers | 117 | Celtics | 127 |
| April | 18, 2022 | Wolves | 122 | Pacers | 117 |
| April | 19, 2022 | Pacers | 107 | Bulls | 133 |
| April | 23, 2022 | Rockets | 127 | Pacers | 123 |
| April | 24, 2022 | Spurs | 111 | Pacers | 121 |