| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Raptors | 107 | Mavericks | 112 |
| November | 5, 2021 | Mavericks | 116 | Warriors | 98 |
| November | 8, 2021 | Jazz | 108 | Mavericks | 156 |
| November | 11, 2021 | Mavericks | 122 | Bucks | 114 |
| November | 12, 2021 | Mavericks | 100 | Blazers | 102 |
| November | 14, 2021 | Mavericks | 99 | Kings | 107 |
| November | 15, 2021 | Hawks | 105 | Mavericks | 139 |
| November | 18, 2021 | Spurs | 114 | Mavericks | 129 |
| November | 20, 2021 | Mavericks | 104 | Kings | 80 |
| November | 24, 2021 | Mavericks | 121 | Rockets | 127 |
| November | 25, 2021 | Mavericks | 115 | Pacers | 98 |
| November | 26, 2021 | Mavericks | 132 | Nuggets | 127 |
| November | 27, 2021 | Mavericks | 106 | Wolves | 110 |
| November | 28, 2021 | Mavericks | 118 | Celtics | 127 |
| December | 3, 2021 | Warriors | 102 | Mavericks | 130 |
| December | 5, 2021 | Nuggets | 113 | Mavericks | 122 |
| December | 10, 2021 | Mavericks | 124 | Suns | 122 |
| December | 14, 2021 | Mavericks | 132 | Hawks | 90 |
| December | 16, 2021 | Mavericks | 143 | Jazz | 102 |
| December | 18, 2021 | Clippers | 112 | Mavericks | 118 |
| December | 19, 2021 | Mavericks | 131 | Clippers | 103 |
| December | 20, 2021 | Spurs | 105 | Mavericks | 116 |
| December | 21, 2021 | Mavericks | 92 | Nets | 97 |
| December | 22, 2021 | Mavericks | 122 | Spurs | 89 |
| December | 27, 2021 | Blazers | 101 | Mavericks | 114 |
| December | 28, 2021 | Blazers | 85 | Mavericks | 104 |
| December | 30, 2021 | Mavericks | 122 | Clippers | 124 |
| December | 31, 2021 | Mavericks | 101 | Rockets | 93 |
| January | 1, 2022 | Mavericks | 121 | Suns | 138 |
| January | 4, 2022 | Bucks | 116 | Mavericks | 117 |
| January | 5, 2022 | Bulls | 97 | Mavericks | 127 |
| January | 7, 2022 | Mavericks | 116 | 76ers | 115 |
| January | 9, 2022 | Mavericks | 135 | Jazz | 117 |
| January | 13, 2022 | Mavericks | 114 | Wolves | 109 |
| January | 14, 2022 | Lakers | 118 | Mavericks | 120 |
| January | 15, 2022 | Mavericks | 119 | Rockets | 123 |
| January | 16, 2022 | Jazz | 124 | Mavericks | 121 |
| January | 17, 2022 | Spurs | 120 | Mavericks | 136 |
| January | 20, 2022 | Mavericks | 130 | Spurs | 124 |
| January | 22, 2022 | Rockets | 122 | Mavericks | 107 |
| January | 24, 2022 | Jazz | 109 | Mavericks | 125 |
| January | 25, 2022 | Mavericks | 101 | Sonics | 114 |
| January | 28, 2022 | Suns | 101 | Mavericks | 128 |
| January | 29, 2022 | Nuggets | 130 | Mavericks | 116 |
| January | 31, 2022 | Mavericks | 134 | Nuggets | 136 |
| February | 2, 2022 | Mavericks | 89 | Wolves | 142 |
| February | 4, 2022 | Kings | 71 | Mavericks | 109 |
| February | 8, 2022 | Heat | 101 | Mavericks | 104 |
| February | 12, 2022 | Mavericks | 117 | Pelicans | 119 |
| February | 13, 2022 | Mavericks | 104 | Nuggets | 143 |
| February | 14, 2022 | Mavericks | 123 | Bulls | 127 |
| February | 15, 2022 | Mavericks | 105 | Raptors | 106 |
| February | 17, 2022 | Mavericks | 119 | Grizzlies | 133 |
| February | 19, 2022 | Rockets | 124 | Mavericks | 110 |
| February | 20, 2022 | 76ers | 100 | Mavericks | 104 |
| February | 22, 2022 | Pelicans | 96 | Mavericks | 128 |
| February | 23, 2022 | Wolves | 125 | Mavericks | 120 |
| February | 24, 2022 | Mavericks | 132 | Warriors | 106 |
| February | 27, 2022 | Mavericks | 123 | Suns | 109 |
| March | 1, 2022 | Clippers | 123 | Mavericks | 120 |
| March | 4, 2022 | Warriors | 128 | Mavericks | 133 |
| March | 6, 2022 | Mavericks | 115 | Lakers | 104 |
| March | 8, 2022 | Knicks | 129 | Mavericks | 100 |
| March | 10, 2022 | Wolves | 124 | Mavericks | 109 |
| March | 13, 2022 | Rockets | 118 | Mavericks | 111 |
| March | 14, 2022 | Kings | 82 | Mavericks | 115 |
| March | 15, 2022 | Mavericks | 128 | Spurs | 111 |
| March | 20, 2022 | Wolves | 121 | Mavericks | 126 |
| March | 27, 2022 | Sonics | 110 | Mavericks | 136 |
| April | 2, 2022 | Lakers | 108 | Mavericks | 117 |
| April | 3, 2022 | Mavericks | 113 | Knicks | 121 |
| April | 5, 2022 | Pacers | 105 | Mavericks | 114 |
| April | 8, 2022 | Suns | 95 | Mavericks | 120 |
| April | 9, 2022 | Mavericks | 111 | Sonics | 122 |
| April | 10, 2022 | Mavericks | 78 | Blazers | 103 |
| April | 12, 2022 | Grizzlies | 112 | Mavericks | 124 |
| April | 15, 2022 | Suns | 107 | Mavericks | 106 |
| April | 17, 2022 | Sonics | 85 | Mavericks | 121 |
| April | 21, 2022 | Mavericks | 92 | Heat | 83 |
| April | 23, 2022 | Mavericks | 106 | Lakers | 113 |
| April | 24, 2022 | Celtics | 122 | Mavericks | 133 |
| April | 25, 2022 | Nets | 125 | Mavericks | 122 |
| Post | 1, 2022 | Mavericks | 126 | Nuggets | 108 |
| Post | 2, 2022 | Mavericks | 108 | Nuggets | 125 |
| Post | 3, 2022 | Nuggets | 113 | Mavericks | 143 |
| Post | 4, 2022 | Nuggets | 123 | Mavericks | 100 |
| Post | 5, 2022 | Mavericks | 100 | Nuggets | 112 |
| Post | 6, 2022 | Nuggets | 97 | Mavericks | 131 |
| Post | 7, 2022 | Mavericks | 110 | Nuggets | 134 |