| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Warriors | 106 | Lakers | 126 |
| November | 4, 2021 | Warriors | 101 | Lakers | 107 |
| November | 5, 2021 | Clippers | 126 | Lakers | 121 |
| November | 6, 2021 | Lakers | 96 | Hawks | 100 |
| November | 7, 2021 | Lakers | 112 | Jazz | 100 |
| November | 8, 2021 | Bulls | 105 | Lakers | 101 |
| November | 10, 2021 | Lakers | 113 | Clippers | 120 |
| November | 12, 2021 | Lakers | 115 | Nuggets | 138 |
| November | 13, 2021 | Lakers | 120 | Spurs | 96 |
| November | 14, 2021 | Lakers | 106 | Wolves | 118 |
| November | 15, 2021 | Kings | 88 | Lakers | 98 |
| November | 20, 2021 | Lakers | 106 | Bucks | 128 |
| November | 22, 2021 | Suns | 87 | Lakers | 95 |
| November | 23, 2021 | Lakers | 100 | Heat | 109 |
| November | 25, 2021 | Sonics | 96 | Lakers | 125 |
| November | 26, 2021 | Lakers | 106 | Warriors | 105 |
| December | 1, 2021 | Pelicans | 131 | Lakers | 109 |
| December | 3, 2021 | Rockets | 84 | Lakers | 81 |
| December | 5, 2021 | Lakers | 70 | Kings | 96 |
| December | 7, 2021 | Clippers | 132 | Lakers | 111 |
| December | 8, 2021 | Kings | 111 | Lakers | 116 |
| December | 12, 2021 | Lakers | 106 | Raptors | 137 |
| December | 14, 2021 | Lakers | 110 | Clippers | 112 |
| December | 15, 2021 | Grizzlies | 107 | Lakers | 110 |
| December | 19, 2021 | Jazz | 108 | Lakers | 115 |
| December | 21, 2021 | Sonics | 132 | Lakers | 115 |
| December | 23, 2021 | Knicks | 138 | Lakers | 106 |
| December | 24, 2021 | Clippers | 106 | Lakers | 110 |
| December | 25, 2021 | Lakers | 108 | Clippers | 111 |
| December | 29, 2021 | Lakers | 76 | Blazers | 121 |
| December | 31, 2021 | Lakers | 118 | Celtics | 109 |
| January | 2, 2022 | Rockets | 128 | Lakers | 117 |
| January | 5, 2022 | Lakers | 98 | Spurs | 113 |
| January | 6, 2022 | Heat | 112 | Lakers | 123 |
| January | 7, 2022 | Kings | 82 | Lakers | 91 |
| January | 8, 2022 | Lakers | 106 | Nets | 92 |
| January | 14, 2022 | Lakers | 118 | Mavericks | 120 |
| January | 15, 2022 | Lakers | 74 | Blazers | 105 |
| January | 16, 2022 | Raptors | 134 | Lakers | 119 |
| January | 18, 2022 | Lakers | 88 | Rockets | 136 |
| January | 20, 2022 | Lakers | 90 | Nuggets | 123 |
| January | 21, 2022 | Lakers | 89 | Kings | 81 |
| January | 23, 2022 | Lakers | 103 | Jazz | 114 |
| January | 31, 2022 | Lakers | 92 | Knicks | 124 |
| February | 1, 2022 | Sonics | 103 | Lakers | 114 |
| February | 8, 2022 | Nuggets | 120 | Lakers | 98 |
| February | 9, 2022 | 76ers | 87 | Lakers | 102 |
| February | 14, 2022 | Blazers | 83 | Lakers | 99 |
| February | 15, 2022 | Lakers | 106 | Warriors | 107 |
| February | 18, 2022 | Jazz | 99 | Lakers | 127 |
| February | 20, 2022 | Lakers | 100 | Rockets | 143 |
| February | 21, 2022 | Nets | 131 | Lakers | 93 |
| February | 22, 2022 | Lakers | 119 | Suns | 129 |
| February | 25, 2022 | Celtics | 117 | Lakers | 113 |
| February | 28, 2022 | Lakers | 85 | Pelicans | 119 |
| March | 1, 2022 | Lakers | 98 | 76ers | 96 |
| March | 2, 2022 | Wolves | 115 | Lakers | 106 |
| March | 3, 2022 | Lakers | 92 | Grizzlies | 119 |
| March | 6, 2022 | Mavericks | 115 | Lakers | 104 |
| March | 9, 2022 | Spurs | 110 | Lakers | 98 |
| March | 10, 2022 | Warriors | 109 | Lakers | 120 |
| March | 12, 2022 | Spurs | 113 | Lakers | 110 |
| March | 16, 2022 | Bucks | 126 | Lakers | 129 |
| March | 18, 2022 | Suns | 84 | Lakers | 103 |
| March | 19, 2022 | Nuggets | 139 | Lakers | 121 |
| March | 23, 2022 | Lakers | 108 | Sonics | 110 |
| March | 26, 2022 | Lakers | 91 | Kings | 101 |
| March | 27, 2022 | Wolves | 121 | Lakers | 110 |
| March | 28, 2022 | Lakers | 90 | Blazers | 116 |
| March | 31, 2022 | Pacers | 94 | Lakers | 104 |
| April | 2, 2022 | Lakers | 108 | Mavericks | 117 |
| April | 8, 2022 | Lakers | 112 | Bulls | 117 |
| April | 10, 2022 | Lakers | 104 | Pacers | 134 |
| April | 11, 2022 | Lakers | 101 | Warriors | 108 |
| April | 15, 2022 | Blazers | 95 | Lakers | 107 |
| April | 16, 2022 | Lakers | 105 | Sonics | 111 |
| April | 17, 2022 | Hawks | 112 | Lakers | 118 |
| April | 18, 2022 | Lakers | 98 | Suns | 120 |
| April | 21, 2022 | Lakers | 100 | Wolves | 118 |
| April | 22, 2022 | Lakers | 120 | Sonics | 113 |
| April | 23, 2022 | Mavericks | 106 | Lakers | 113 |
| April | 25, 2022 | Blazers | 104 | Lakers | 106 |