| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Nuggets | 108 | Grizzlies | 112 |
| November | 6, 2021 | Grizzlies | 109 | Wolves | 101 |
| November | 11, 2021 | Warriors | 111 | Grizzlies | 124 |
| November | 13, 2021 | Grizzlies | 98 | Celtics | 117 |
| November | 17, 2021 | Grizzlies | 102 | Nets | 124 |
| November | 18, 2021 | Hawks | 116 | Grizzlies | 117 |
| November | 19, 2021 | Grizzlies | 100 | Spurs | 105 |
| November | 21, 2021 | Bulls | 118 | Grizzlies | 111 |
| November | 22, 2021 | Grizzlies | 83 | Heat | 120 |
| November | 23, 2021 | Pelicans | 106 | Grizzlies | 115 |
| November | 24, 2021 | Grizzlies | 112 | Knicks | 104 |
| November | 26, 2021 | Grizzlies | 107 | Celtics | 118 |
| November | 27, 2021 | Grizzlies | 96 | Pelicans | 110 |
| December | 5, 2021 | Nets | 104 | Grizzlies | 105 |
| December | 9, 2021 | Wolves | 93 | Grizzlies | 112 |
| December | 11, 2021 | Bulls | 91 | Grizzlies | 111 |
| December | 12, 2021 | Grizzlies | 116 | Pacers | 101 |
| December | 15, 2021 | Grizzlies | 107 | Lakers | 110 |
| December | 17, 2021 | Grizzlies | 94 | Suns | 99 |
| December | 18, 2021 | Raptors | 110 | Grizzlies | 120 |
| December | 23, 2021 | Grizzlies | 127 | Bucks | 110 |
| December | 24, 2021 | Grizzlies | 143 | Raptors | 131 |
| December | 25, 2021 | Grizzlies | 104 | 76ers | 95 |
| December | 28, 2021 | Grizzlies | 122 | Hawks | 128 |
| December | 30, 2021 | Grizzlies | 106 | Hawks | 99 |
| January | 1, 2022 | Grizzlies | 117 | Celtics | 115 |
| January | 2, 2022 | Celtics | 131 | Grizzlies | 111 |
| January | 3, 2022 | Jazz | 103 | Grizzlies | 122 |
| January | 4, 2022 | Grizzlies | 112 | 76ers | 76 |
| January | 10, 2022 | Grizzlies | 110 | Nets | 103 |
| January | 13, 2022 | Grizzlies | 116 | Pacers | 109 |
| January | 14, 2022 | Raptors | 96 | Grizzlies | 111 |
| January | 16, 2022 | Suns | 120 | Grizzlies | 136 |
| January | 19, 2022 | Grizzlies | 103 | Sonics | 95 |
| January | 22, 2022 | Grizzlies | 107 | Heat | 108 |
| January | 23, 2022 | Pacers | 111 | Grizzlies | 116 |
| January | 24, 2022 | Grizzlies | 112 | Knicks | 106 |
| January | 26, 2022 | Rockets | 127 | Grizzlies | 125 |
| January | 28, 2022 | Bulls | 100 | Grizzlies | 108 |
| January | 30, 2022 | Grizzlies | 113 | Knicks | 111 |
| February | 1, 2022 | Grizzlies | 127 | Bucks | 104 |
| February | 4, 2022 | Clippers | 119 | Grizzlies | 127 |
| February | 13, 2022 | 76ers | 94 | Grizzlies | 117 |
| February | 14, 2022 | Grizzlies | 109 | Raptors | 121 |
| February | 17, 2022 | Mavericks | 119 | Grizzlies | 133 |
| February | 18, 2022 | Bucks | 115 | Grizzlies | 113 |
| February | 19, 2022 | Bulls | 98 | Grizzlies | 126 |
| February | 20, 2022 | Grizzlies | 102 | Bulls | 112 |
| February | 21, 2022 | Grizzlies | 106 | Pacers | 115 |
| February | 24, 2022 | Bucks | 114 | Grizzlies | 124 |
| February | 25, 2022 | Bucks | 104 | Grizzlies | 122 |
| February | 26, 2022 | Bucks | 122 | Grizzlies | 116 |
| March | 3, 2022 | Lakers | 92 | Grizzlies | 119 |
| March | 5, 2022 | 76ers | 111 | Grizzlies | 100 |
| March | 8, 2022 | Grizzlies | 117 | Rockets | 137 |
| March | 9, 2022 | Kings | 81 | Grizzlies | 97 |
| March | 11, 2022 | Hawks | 118 | Grizzlies | 120 |
| March | 13, 2022 | Pelicans | 115 | Grizzlies | 116 |
| March | 14, 2022 | Raptors | 117 | Grizzlies | 126 |
| March | 16, 2022 | Grizzlies | 122 | Bulls | 132 |
| March | 18, 2022 | Grizzlies | 105 | Raptors | 117 |
| March | 20, 2022 | Sonics | 109 | Grizzlies | 114 |
| March | 21, 2022 | Grizzlies | 104 | Nuggets | 102 |
| March | 23, 2022 | Grizzlies | 119 | Clippers | 116 |
| March | 24, 2022 | Pelicans | 86 | Grizzlies | 105 |
| March | 26, 2022 | Grizzlies | 113 | Jazz | 133 |
| March | 29, 2022 | Spurs | 99 | Grizzlies | 106 |
| March | 30, 2022 | Grizzlies | 86 | Nets | 120 |
| April | 6, 2022 | Grizzlies | 91 | Blazers | 90 |
| April | 7, 2022 | Pacers | 118 | Grizzlies | 120 |
| April | 12, 2022 | Grizzlies | 112 | Mavericks | 124 |
| April | 13, 2022 | Blazers | 92 | Grizzlies | 113 |
| April | 14, 2022 | Heat | 105 | Grizzlies | 108 |
| April | 16, 2022 | Grizzlies | 95 | Hawks | 138 |
| April | 17, 2022 | Nets | 113 | Grizzlies | 96 |
| April | 18, 2022 | Grizzlies | 102 | Kings | 84 |
| April | 19, 2022 | Grizzlies | 96 | Heat | 103 |
| April | 20, 2022 | Heat | 98 | Grizzlies | 116 |
| April | 22, 2022 | Grizzlies | 85 | Warriors | 109 |
| April | 23, 2022 | Knicks | 116 | Grizzlies | 86 |
| April | 25, 2022 | Celtics | 120 | Grizzlies | 130 |
| April | 26, 2022 | Knicks | 118 | Grizzlies | 125 |
| Post | 1, 2022 | Hawks | 122 | Grizzlies | 114 |
| Post | 2, 2022 | Hawks | 90 | Grizzlies | 108 |
| Post | 3, 2022 | Grizzlies | 129 | Hawks | 126 |
| Post | 4, 2022 | Grizzlies | 123 | Hawks | 106 |
| Post | 5, 2022 | Hawks | 122 | Grizzlies | 119 |
| Post | 6, 2022 | Grizzlies | 120 | Hawks | 117 |
| Post | 7, 2022 | Hawks | | Grizzlies | |
| Post | 8, 2022 | Bulls | 138 | Grizzlies | 101 |
| Post | 9, 2022 | Bulls | 120 | Grizzlies | 125 |
| Post | 10, 2022 | Grizzlies | 127 | Bulls | 113 |
| Post | 11, 2022 | Grizzlies | 122 | Bulls | 109 |
| Post | 12, 2022 | Bulls | 114 | Grizzlies | 113 |
| Post | 13, 2022 | Grizzlies | 104 | Bulls | 115 |
| Post | 14, 2022 | Bulls | 126 | Grizzlies | 111 |