| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Celtics | 128 | Knicks | 113 |
| November | 5, 2021 | 76ers | 128 | Celtics | 138 |
| November | 6, 2021 | Celtics | 134 | Raptors | 126 |
| November | 7, 2021 | Celtics | 135 | Heat | 102 |
| November | 10, 2021 | Celtics | 131 | Nets | 112 |
| November | 13, 2021 | Grizzlies | 98 | Celtics | 117 |
| November | 14, 2021 | Raptors | 123 | Celtics | 122 |
| November | 18, 2021 | Rockets | 105 | Celtics | 118 |
| November | 22, 2021 | Kings | 95 | Celtics | 97 |
| November | 23, 2021 | Celtics | 112 | 76ers | 102 |
| November | 24, 2021 | Raptors | 118 | Celtics | 128 |
| November | 25, 2021 | Bulls | 104 | Celtics | 127 |
| November | 26, 2021 | Grizzlies | 107 | Celtics | 118 |
| November | 28, 2021 | Mavericks | 118 | Celtics | 127 |
| November | 29, 2021 | Bucks | 112 | Celtics | 154 |
| November | 30, 2021 | Celtics | 141 | Nets | 108 |
| December | 1, 2021 | Nets | 93 | Celtics | 106 |
| December | 8, 2021 | Celtics | 142 | Pelicans | 133 |
| December | 9, 2021 | Jazz | 96 | Celtics | 128 |
| December | 12, 2021 | Suns | 112 | Celtics | 135 |
| December | 13, 2021 | Nuggets | 112 | Celtics | 132 |
| December | 15, 2021 | Spurs | 106 | Celtics | 120 |
| December | 17, 2021 | Celtics | 108 | Bulls | 113 |
| December | 24, 2021 | Pelicans | 156 | Celtics | 115 |
| December | 26, 2021 | 76ers | 89 | Celtics | 111 |
| December | 28, 2021 | Knicks | 127 | Celtics | 113 |
| December | 31, 2021 | Lakers | 118 | Celtics | 109 |
| January | 1, 2022 | Grizzlies | 117 | Celtics | 115 |
| January | 2, 2022 | Celtics | 131 | Grizzlies | 111 |
| January | 4, 2022 | Wolves | 118 | Celtics | 121 |
| January | 5, 2022 | Pelicans | 141 | Celtics | 135 |
| January | 6, 2022 | 76ers | 112 | Celtics | 120 |
| January | 8, 2022 | Knicks | 115 | Celtics | 120 |
| January | 10, 2022 | Celtics | 119 | Heat | 130 |
| January | 22, 2022 | Celtics | 101 | 76ers | 89 |
| January | 24, 2022 | Celtics | 116 | Hawks | 122 |
| January | 27, 2022 | Celtics | 113 | Sonics | 111 |
| January | 28, 2022 | Celtics | 102 | Pacers | 107 |
| January | 30, 2022 | Celtics | 112 | Wolves | 114 |
| January | 31, 2022 | Celtics | 124 | Hawks | 131 |
| February | 2, 2022 | Heat | 121 | Celtics | 116 |
| February | 13, 2022 | Celtics | 99 | Pelicans | 131 |
| February | 17, 2022 | Celtics | 135 | Warriors | 115 |
| February | 19, 2022 | Celtics | 133 | Raptors | 112 |
| February | 21, 2022 | Celtics | 138 | Jazz | 109 |
| February | 22, 2022 | Nets | 106 | Celtics | 122 |
| February | 23, 2022 | Celtics | 105 | Blazers | 117 |
| February | 24, 2022 | Celtics | 105 | Pelicans | 150 |
| February | 25, 2022 | Celtics | 117 | Lakers | 113 |
| February | 26, 2022 | Clippers | 123 | Celtics | 125 |
| March | 1, 2022 | Bulls | 108 | Celtics | 113 |
| March | 2, 2022 | Hawks | 137 | Celtics | 122 |
| March | 3, 2022 | Warriors | 110 | Celtics | 114 |
| March | 4, 2022 | Celtics | 145 | Knicks | 130 |
| March | 7, 2022 | 76ers | 82 | Celtics | 121 |
| March | 9, 2022 | Celtics | 117 | Bulls | 111 |
| March | 10, 2022 | Bulls | 115 | Celtics | 127 |
| March | 12, 2022 | Bucks | 116 | Celtics | 121 |
| March | 16, 2022 | Pacers | 90 | Celtics | 117 |
| March | 17, 2022 | Celtics | 104 | Knicks | 118 |
| March | 18, 2022 | Celtics | 128 | Knicks | 130 |
| March | 19, 2022 | Heat | 117 | Celtics | 108 |
| March | 20, 2022 | Nets | 124 | Celtics | 136 |
| March | 21, 2022 | Celtics | 137 | Spurs | 134 |
| March | 22, 2022 | Celtics | 133 | Nuggets | 122 |
| March | 23, 2022 | Celtics | 120 | Suns | 116 |
| March | 25, 2022 | Celtics | 130 | Pacers | 106 |
| March | 26, 2022 | Pelicans | 112 | Celtics | 119 |
| March | 28, 2022 | Hawks | 108 | Celtics | 122 |
| March | 29, 2022 | Celtics | 118 | Kings | 107 |
| March | 30, 2022 | Celtics | 139 | Bucks | 119 |
| April | 6, 2022 | Sonics | 118 | Celtics | 124 |
| April | 7, 2022 | Celtics | 119 | Clippers | 131 |
| April | 10, 2022 | Celtics | 109 | Heat | 102 |
| April | 14, 2022 | Blazers | 116 | Celtics | 115 |
| April | 15, 2022 | Celtics | 121 | Bucks | 126 |
| April | 16, 2022 | Pacers | 117 | Celtics | 127 |
| April | 18, 2022 | Celtics | 119 | Heat | 109 |
| April | 20, 2022 | Celtics | 131 | Nets | 139 |
| April | 24, 2022 | Celtics | 122 | Mavericks | 133 |
| April | 25, 2022 | Celtics | 120 | Grizzlies | 130 |
| April | 26, 2022 | Celtics | 142 | Rockets | 140 |
| Post | 1, 2022 | Pelicans | 91 | Celtics | 135 |
| Post | 2, 2022 | Pelicans | 106 | Celtics | 137 |
| Post | 3, 2022 | Celtics | 116 | Pelicans | 117 |
| Post | 4, 2022 | Celtics | 99 | Pelicans | 124 |
| Post | 5, 2022 | Pelicans | 110 | Celtics | 116 |
| Post | 6, 2022 | Celtics | 100 | Pelicans | 148 |
| Post | 7, 2022 | Pelicans | 135 | Celtics | 122 |