| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Nets | 116 | Bulls | 119 |
| November | 8, 2021 | Bulls | 105 | Lakers | 101 |
| November | 9, 2021 | Bulls | 119 | 76ers | 106 |
| November | 10, 2021 | Warriors | 110 | Bulls | 118 |
| November | 14, 2021 | 76ers | 118 | Bulls | 122 |
| November | 15, 2021 | Bulls | 130 | Knicks | 125 |
| November | 16, 2021 | Bulls | 104 | Bucks | 122 |
| November | 17, 2021 | Bulls | 111 | Hawks | 131 |
| November | 19, 2021 | Bulls | 111 | Wolves | 133 |
| November | 20, 2021 | Raptors | 120 | Bulls | 106 |
| November | 21, 2021 | Bulls | 118 | Grizzlies | 111 |
| November | 25, 2021 | Bulls | 104 | Celtics | 127 |
| November | 26, 2021 | Bucks | 122 | Bulls | 118 |
| December | 3, 2021 | Bulls | 102 | Suns | 113 |
| December | 6, 2021 | Bulls | 114 | Hawks | 109 |
| December | 7, 2021 | Bulls | 117 | Pelicans | 119 |
| December | 8, 2021 | Bulls | 96 | Hawks | 121 |
| December | 9, 2021 | Bulls | 92 | Raptors | 136 |
| December | 11, 2021 | Bulls | 91 | Grizzlies | 111 |
| December | 13, 2021 | Bulls | 94 | Kings | 101 |
| December | 14, 2021 | Pelicans | 124 | Bulls | 108 |
| December | 17, 2021 | Celtics | 108 | Bulls | 113 |
| December | 19, 2021 | Knicks | 120 | Bulls | 115 |
| December | 20, 2021 | Suns | 100 | Bulls | 118 |
| December | 21, 2021 | Bulls | 110 | Heat | 125 |
| December | 22, 2021 | Bulls | 122 | Clippers | 98 |
| December | 24, 2021 | Bulls | 97 | Pacers | 106 |
| December | 26, 2021 | Sonics | 130 | Bulls | 132 |
| December | 30, 2021 | Bulls | 129 | Rockets | 118 |
| December | 31, 2021 | Clippers | 125 | Bulls | 120 |
| January | 3, 2022 | Hawks | 108 | Bulls | 130 |
| January | 5, 2022 | Bulls | 97 | Mavericks | 127 |
| January | 7, 2022 | Bulls | 143 | Warriors | 131 |
| January | 9, 2022 | Heat | 111 | Bulls | 128 |
| January | 11, 2022 | Kings | 85 | Bulls | 95 |
| January | 12, 2022 | Bulls | 122 | Jazz | 116 |
| January | 16, 2022 | Bulls | 118 | Hawks | 130 |
| January | 21, 2022 | Jazz | 81 | Bulls | 129 |
| January | 22, 2022 | Hawks | 138 | Bulls | 129 |
| January | 25, 2022 | Spurs | 92 | Bulls | 104 |
| January | 26, 2022 | Pelicans | 136 | Bulls | 114 |
| January | 28, 2022 | Bulls | 100 | Grizzlies | 108 |
| January | 29, 2022 | Wolves | 126 | Bulls | 101 |
| January | 30, 2022 | 76ers | 80 | Bulls | 106 |
| February | 1, 2022 | Pacers | 99 | Bulls | 116 |
| February | 9, 2022 | Bulls | 110 | Nuggets | 122 |
| February | 11, 2022 | Bucks | 105 | Bulls | 91 |
| February | 12, 2022 | Bulls | 126 | Raptors | 110 |
| February | 14, 2022 | Mavericks | 123 | Bulls | 127 |
| February | 16, 2022 | Bulls | 134 | Spurs | 130 |
| February | 18, 2022 | Bulls | 121 | Pacers | 123 |
| February | 19, 2022 | Bulls | 98 | Grizzlies | 126 |
| February | 20, 2022 | Grizzlies | 102 | Bulls | 112 |
| February | 22, 2022 | Bulls | 114 | Pacers | 118 |
| February | 28, 2022 | Bulls | 124 | Bucks | 117 |
| March | 1, 2022 | Bulls | 108 | Celtics | 113 |
| March | 4, 2022 | Raptors | 114 | Bulls | 109 |
| March | 7, 2022 | Bulls | 112 | Nets | 109 |
| March | 8, 2022 | Pelicans | 110 | Bulls | 126 |
| March | 9, 2022 | Celtics | 117 | Bulls | 111 |
| March | 10, 2022 | Bulls | 115 | Celtics | 127 |
| March | 16, 2022 | Grizzlies | 122 | Bulls | 132 |
| March | 20, 2022 | Heat | 97 | Bulls | 114 |
| March | 21, 2022 | Bulls | 107 | 76ers | 83 |
| March | 22, 2022 | Bulls | 89 | Blazers | 118 |
| March | 23, 2022 | Nets | 109 | Bulls | 121 |
| March | 24, 2022 | Blazers | 95 | Bulls | 91 |
| March | 27, 2022 | Rockets | 114 | Bulls | 123 |
| March | 28, 2022 | Pacers | 104 | Bulls | 108 |
| March | 31, 2022 | Nuggets | 134 | Bulls | 106 |
| April | 1, 2022 | Knicks | 96 | Bulls | 117 |
| April | 4, 2022 | Bulls | 117 | Heat | 111 |
| April | 5, 2022 | Bulls | 112 | Knicks | 118 |
| April | 6, 2022 | Nets | 111 | Bulls | 134 |
| April | 8, 2022 | Lakers | 112 | Bulls | 117 |
| April | 9, 2022 | Bulls | 129 | 76ers | 85 |
| April | 15, 2022 | Raptors | 131 | Bulls | 124 |
| April | 18, 2022 | Bulls | 109 | Sonics | 103 |
| April | 19, 2022 | Pacers | 107 | Bulls | 133 |
| April | 21, 2022 | Bucks | 114 | Bulls | 127 |
| April | 24, 2022 | Bulls | 133 | Raptors | 113 |
| April | 26, 2022 | Bucks | 106 | Bulls | 129 |
| Post | 1, 2022 | Bulls | 119 | Nets | 105 |
| Post | 2, 2022 | Bulls | 124 | Nets | 109 |
| Post | 3, 2022 | Nets | 90 | Bulls | 110 |
| Post | 4, 2022 | Nets | 117 | Bulls | 127 |
| Post | 5, 2022 | Bulls | | Nets | |
| Post | 6, 2022 | Nets | | Bulls | |
| Post | 7, 2022 | Bulls | | Nets | |
| Post | 8, 2022 | Bulls | 138 | Grizzlies | 101 |
| Post | 9, 2022 | Bulls | 120 | Grizzlies | 125 |
| Post | 10, 2022 | Grizzlies | 127 | Bulls | 113 |
| Post | 11, 2022 | Grizzlies | 122 | Bulls | 109 |
| Post | 12, 2022 | Bulls | 114 | Grizzlies | 113 |
| Post | 13, 2022 | Grizzlies | 104 | Bulls | 115 |
| Post | 14, 2022 | Bulls | 126 | Grizzlies | 111 |
| Post | 15, 2022 | Pelicans | 129 | Bulls | 114 |
| Post | 16, 2022 | Pelicans | 113 | Bulls | 95 |
| Post | 17, 2022 | Bulls | 126 | Pelicans | 120 |
| Post | 18, 2022 | Bulls | 106 | Pelicans | 128 |
| Post | 19, 2022 | Pelicans | 105 | Bulls | 112 |
| Post | 20, 2022 | Bulls | 121 | Pelicans | 103 |
| Post | 21, 2022 | Pelicans | 121 | Bulls | 98 |